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    Cdc25b cell division cycle 25B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171103, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cdc25bprovided by RGD
    Official Full Name
    cell division cycle 25Bprovided by RGD
    Primary source
    RGD:621500
    See related
    EnsemblRapid:ENSRNOG00000021248 AllianceGenome:RGD:621500
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein kinase binding activity and protein tyrosine phosphatase activity. Predicted to be involved in G2/M transition of mitotic cell cycle; positive regulation of cell cycle process; and protein phosphorylation. Predicted to act upstream of or within female meiosis I; oocyte maturation; and positive regulation of protein kinase activity. Predicted to be located in centrosome and spindle pole. Predicted to be active in cytoplasm and nucleus. Orthologous to human CDC25B (cell division cycle 25B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 404.3), Lung (RPKM 87.2) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Cdc25b in Genome Data Viewer
    Location:
    3q36
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (138860148..138870287)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (118407127..118417272)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (123731539..123741696)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene centromere protein B Neighboring gene uncharacterized LOC134486156 Neighboring gene adaptor related protein complex 5 subunit sigma 1 Neighboring gene mitochondrial antiviral signaling protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphoprotein phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphoprotein phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in female meiosis I IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within female meiosis I ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in oocyte maturation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within oocyte maturation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of G2/M transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of G2/M transition of mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of G2/MI transition of meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cell cycle G2/M phase transition IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cytokinesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
     
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle pole ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    M-phase inducer phosphatase 2
    Names
    dual specificity phosphatase Cdc25B
    NP_001376142.1
    NP_598256.2
    XP_038960121.1
    XP_038960123.1
    XP_063139110.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001389213.1NP_001376142.1  M-phase inducer phosphatase 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6A7K8, A0A8I6GIX5
      Related
      ENSRNOP00000091343.2, ENSRNOT00000119042.2
      Conserved Domains (2) summary
      cd01530
      Location:381500
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
      pfam06617
      Location:111352
      M-inducer_phosp; M-phase inducer phosphatase
    2. NM_001429734.1NP_001416663.1  M-phase inducer phosphatase 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      P48966
    3. NM_001429735.1NP_001416664.1  M-phase inducer phosphatase 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6A7K8
    4. NM_133572.2NP_598256.2  M-phase inducer phosphatase 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      P48966
      UniProtKB/TrEMBL
      A6HQC8, F1LQS5
      Related
      ENSRNOP00000106275.1, ENSRNOT00000122290.1
      Conserved Domains (2) summary
      cd01530
      Location:407526
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
      pfam06617
      Location:111378
      M-inducer_phosp; M-phase inducer phosphatase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      138860148..138870287
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283040.1XP_063139110.1  M-phase inducer phosphatase 2 isoform X2

      Related
      ENSRNOP00000088213.2, ENSRNOT00000101513.2
    2. XM_039104193.2XP_038960121.1  M-phase inducer phosphatase 2 isoform X1

      Related
      ENSRNOP00000096779.1, ENSRNOT00000103719.2
      Conserved Domains (2) summary
      cd01530
      Location:393512
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
      pfam06617
      Location:111364
      M-inducer_phosp; M-phase inducer phosphatase
    3. XM_039104195.2XP_038960123.1  M-phase inducer phosphatase 2 isoform X3

      Conserved Domains (2) summary
      cd01530
      Location:209328
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
      pfam06617
      Location:1180
      M-inducer_phosp; M-phase inducer phosphatase