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    Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25451, updated on 3-Dec-2024

    Summary

    Official Symbol
    Gabrb2provided by RGD
    Official Full Name
    gamma-aminobutyric acid type A receptor subunit beta 2provided by RGD
    Primary source
    RGD:2650
    See related
    EnsemblRapid:ENSRNOG00000003680 AllianceGenome:RGD:2650
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    GARB2
    Summary
    Enables GABA-A receptor activity and monoatomic ion channel activity. Contributes to GABA receptor activity. Involved in GABAergic synaptic transmission; cellular response to histamine; and chloride transmembrane transport. Located in plasma membrane. Part of GABA-A receptor complex. Is active in GABA-ergic synapse; glutamatergic synapse; and synaptic membrane. Human ortholog(s) of this gene implicated in autistic disorder and developmental and epileptic encephalopathy 92. Orthologous to human GABRB2 (gamma-aminobutyric acid type A receptor subunit beta2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 272.9) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Gabrb2 in Genome Data Viewer
    Location:
    10q21
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (27438127..27657680)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (26936592..27156141)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (27973694..28193072)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene gamma-aminobutyric acid type A receptor subunit alpha6 Neighboring gene uncharacterized LOC134480630 Neighboring gene uncharacterized LOC134480669 Neighboring gene uncharacterized LOC134480671 Neighboring gene ATPase phospholipid transporting 10B Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to GABA receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to GABA receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables GABA-A receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GABA-A receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GABA-A receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables GABA-A receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables GABA-gated chloride ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to GABA-gated chloride ion channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to GABA-gated chloride ion channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables chloride channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables chloride channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables extracellular ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables inhibitory extracellular ligand-gated monoatomic ion channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to histamine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chloride transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chloride transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cochlea development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cochlea development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in gamma-aminobutyric acid signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in gamma-aminobutyric acid signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in gamma-aminobutyric acid signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in gamma-aminobutyric acid signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in inhibitory synapse assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inhibitory synapse assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in inhibitory synapse assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in inner ear receptor cell development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inner ear receptor cell development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in innervation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innervation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of presynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in synaptic transmission, GABAergic IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of GABA receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of GABA-A receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of GABA-A receptor complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of GABA-A receptor complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    part_of GABA-A receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of GABA-A receptor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in GABA-ergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in GABA-ergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    part_of chloride channel complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic specialization membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic specialization membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic specialization membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynaptic specialization membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in presynaptic active zone membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    gamma-aminobutyric acid receptor subunit beta-2
    Names
    GABA(A) receptor subunit beta-2
    GABAAR subunit beta-2
    Gamma-aminobutyric acid receptor beta 2
    gamma-aminobutyric acid (GABA) A receptor, beta 2
    gamma-aminobutyric acid (GABA-A) receptor, subunit beta 2
    gamma-aminobutyric acid type A receptor beta 2 subunit

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430104.1NP_001417033.1  gamma-aminobutyric acid receptor subunit beta-2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      P63138
      UniProtKB/TrEMBL
      A0A8I6AGU9, A6HDL9
    2. NM_012957.3NP_037089.1  gamma-aminobutyric acid receptor subunit beta-2 precursor

      See identical proteins and their annotated locations for NP_037089.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      P63138
      UniProtKB/TrEMBL
      A0A8I6AGU9, A6HDL9
      Conserved Domains (1) summary
      TIGR00860
      Location:9472
      LIC; Cation transporter family protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      27438127..27657680
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246127.4XP_006246189.1  gamma-aminobutyric acid receptor subunit beta-2 isoform X1

      Related
      ENSRNOP00000081083.1, ENSRNOT00000118632.2
      Conserved Domains (1) summary
      TIGR00860
      Location:9472
      LIC; Cation transporter family protein
    2. XM_008767635.4XP_008765857.1  gamma-aminobutyric acid receptor subunit beta-2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AGU9, A0A8L2Q2J9
      Related
      ENSRNOP00000004970.4, ENSRNOT00000004970.7
      Conserved Domains (3) summary
      TIGR00860
      Location:9504
      LIC; Cation transporter family protein
      pfam02931
      Location:40242
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:249501
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
    3. XM_039085275.2XP_038941203.1  gamma-aminobutyric acid receptor subunit beta-2 isoform X1

      Conserved Domains (1) summary
      TIGR00860
      Location:9472
      LIC; Cation transporter family protein