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    Pitx1 paired-like homeodomain 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 113983, updated on 27-Nov-2024

    Summary

    Official Symbol
    Pitx1provided by RGD
    Official Full Name
    paired-like homeodomain 1provided by RGD
    Primary source
    RGD:69253
    See related
    EnsemblRapid:ENSRNOG00000011423 AllianceGenome:RGD:69253
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Bft
    Summary
    Enables DNA-binding transcription factor activity. Involved in regulation of DNA-templated transcription. Predicted to be located in cytoplasm. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in clubfoot. Orthologous to human PITX1 (paired like homeodomain 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 8.6) and Muscle (RPKM 3.9) See more
    Orthologs
    NEW
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    Genomic context

    See Pitx1 in Genome Data Viewer
    Location:
    17p14
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (8794051..8805477)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (8794134..8800292)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (8873184..8884428)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482673 Neighboring gene uncharacterized LOC120097949 Neighboring gene uncharacterized LOC103694034 Neighboring gene cation channel, sperm associated 3 Neighboring gene uncharacterized LOC134482674

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within branchiomeric skeletal muscle development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cartilage development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryonic hindlimb morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in embryonic hindlimb morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within hindlimb morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within myoblast fate commitment ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within pituitary gland development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within skeletal system development ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    pituitary homeobox 1
    Names
    homeobox protein PITX1
    paired-like homeodomain transcription factor 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053624.2NP_446076.1  pituitary homeobox 1

      See identical proteins and their annotated locations for NP_446076.1

      Status: PROVISIONAL

      Source sequence(s)
      BC061966
      UniProtKB/Swiss-Prot
      Q99NA7
      UniProtKB/TrEMBL
      A6KAP5
      Related
      ENSRNOP00000015307.4, ENSRNOT00000015307.8
      Conserved Domains (2) summary
      pfam00046
      Location:93146
      Homeobox; Homeobox domain
      pfam03826
      Location:277294
      OAR; OAR domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      8794051..8805477
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276016.1XP_063132086.1  pituitary homeobox 1 isoform X1

      UniProtKB/Swiss-Prot
      Q99NA7
      UniProtKB/TrEMBL
      A6KAP5
    2. XM_063276015.1XP_063132085.1  pituitary homeobox 1 isoform X1

      UniProtKB/Swiss-Prot
      Q99NA7
      UniProtKB/TrEMBL
      A6KAP5