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    Fbxw27 F-box and WD-40 domain protein 27 [ Mus musculus (house mouse) ]

    Gene ID: 76998, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fbxw27provided by MGI
    Official Full Name
    F-box and WD-40 domain protein 27provided by MGI
    Primary source
    MGI:MGI:1924248
    See related
    Ensembl:ENSMUSG00000104614 AllianceGenome:MGI:1924248
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700124P09Rik
    Summary
    Predicted to be active in cytoplasm. Orthologous to human FBXW12 (F-box and WD repeat domain containing 12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 3.9), bladder adult (RPKM 2.6) and 1 other tissue See more
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    Genomic context

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    See Fbxw27 in Genome Data Viewer
    Location:
    9 F2; 9 59.74 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (109595045..109620484, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (109765977..109790660, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene F-box and WD-40 domain protein 18 Neighboring gene F-box and WD-40 domain protein 26 Neighboring gene predicted gene, 40579 Neighboring gene predicted gene, 51691 Neighboring gene serine peptidase inhibitor, Kazal type 8 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
    2. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    3. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    4. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article
    5. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Carninci P, et al. Genome Res, 2000 Oct. PMID 11042159, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    F-box and WD-40 domain protein 27

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001303003.1 → NP_001289932.1  F-box and WD-40 domain protein 27 isoform 1

      See identical proteins and their annotated locations for NP_001289932.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK007274, BB702760, CJ082096, CO804891, DV663185
      UniProtKB/TrEMBL
      A0A1D5RLF0
      Related
      ENSMUSP00000148340.2, ENSMUST00000212725.2
      Conserved Domains (1) summary
      pfam12937
      Location:5 → 48
      F-box-like; F-box-like

    2. NM_001303004.1 → NP_001289933.1  F-box and WD-40 domain protein 27 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks four consecutive exons in the coding region, which results in a frameshift compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK007274, CJ082096, CO804891, DV663185
      Consensus CDS
      CCDS85731.1
      UniProtKB/TrEMBL
      A0A1D5RLI0
      Related
      ENSMUSP00000148376.2, ENSMUST00000197125.3
      Conserved Domains (1) summary
      pfam12937
      Location:5 → 48
      F-box-like; F-box-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      109595045..109620484 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003084806.5 → XP_003084854.1  F-box and WD-40 domain protein 27 isoform X2

      UniProtKB/TrEMBL
      A0A1D5RLF0

    2. XM_001481022.6 → XP_001481072.1  F-box and WD-40 domain protein 27 isoform X1

      UniProtKB/TrEMBL
      A0A1D5RMD3
      Related
      ENSMUSP00000148730.2, ENSMUST00000199430.5
      Conserved Domains (1) summary
      pfam12937
      Location:5 → 46
      F-box-like
    Nucleotide Protein Strain
    Heading Accession and Version

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