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    Snx32 sorting nexin 32 [ Mus musculus (house mouse) ]

    Gene ID: 225861, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Snx32provided by MGI
    Official Full Name
    sorting nexin 32provided by MGI
    Primary source
    MGI:MGI:2444704
    See related
    Ensembl:ENSMUSG00000056185 AllianceGenome:MGI:2444704
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Snx6b; B930037P14Rik
    Summary
    Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in retrograde transport, endosome to Golgi. Predicted to be active in endosome. Orthologous to human SNX32 (sorting nexin 32). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 35.4), frontal lobe adult (RPKM 30.4) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Snx32 in Genome Data Viewer
    Location:
    19 A; 19 4.34 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (5545302..5560741, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (5495274..5510708, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:5488369-5488552 Neighboring gene STARR-positive B cell enhancer ABC_E779 Neighboring gene STARR-positive B cell enhancer ABC_E8730 Neighboring gene MUS81 structure-specific endonuclease subunit Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:5491370-5491523 Neighboring gene cofilin 1, non-muscle Neighboring gene NSE3 homolog, SMC5-SMC6 complex component like Neighboring gene STARR-positive B cell enhancer ABC_E1208 Neighboring gene predicted gene, 31166 Neighboring gene ovo like zinc finger 1 Neighboring gene adaptor-related protein complex 5, beta 1 subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    2. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sorting nexin-32
    Names
    sortin nexin-6B
    sorting nexin-6B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024560.3 → NP_001019731.1  sorting nexin-32 isoform 1

      See identical proteins and their annotated locations for NP_001019731.1

      Status: VALIDATED

      Source sequence(s)
      AI846187, BB597960, BC048922
      Consensus CDS
      CCDS29468.1
      UniProtKB/Swiss-Prot
      Q80ZJ7
      Related
      ENSMUSP00000070915.5, ENSMUST00000070172.6
      Conserved Domains (2) summary
      cd07621
      Location:181 → 401
      BAR_SNX5_6; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexins 5 and 6
      cl02563
      Location:27 → 164
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    2. NM_001362042.1 → NP_001348971.1  sorting nexin-32 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AI846187, AK047234, AK143441, BB597960
      Consensus CDS
      CCDS89312.1
      UniProtKB/TrEMBL
      A0A494B972
      Related
      ENSMUSP00000157473.2, ENSMUST00000237111.2
      Conserved Domains (2) summary
      cd07621
      Location:181 → 393
      BAR_SNX5_6; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexins 5 and 6
      cl02563
      Location:27 → 164
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      5545302..5560741 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248617.4 → XP_011246919.1  sorting nexin-32 isoform X1

      Conserved Domains (2) summary
      cd06892
      Location:27 → 164
      PX_SNX5_like; The phosphoinositide binding Phox Homology domain of Sorting Nexins 5 and 6
      cl12013
      Location:181 → 305
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    2. XM_030250871.2 → XP_030106731.1  sorting nexin-32 isoform X4

      Conserved Domains (2) summary
      cd07621
      Location:62 → 282
      BAR_SNX5_6; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexins 5 and 6
      cl02563
      Location:1 → 45
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    3. XM_030250870.2 → XP_030106730.1  sorting nexin-32 isoform X3

      Conserved Domains (2) summary
      cd07621
      Location:62 → 274
      BAR_SNX5_6; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexins 5 and 6
      cl02563
      Location:1 → 45
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    4. XM_011248618.3 → XP_011246920.1  sorting nexin-32 isoform X2

      Conserved Domains (2) summary
      cl02563
      Location:1 → 45
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
      cl12013
      Location:62 → 186
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    5. XM_036161522.1 → XP_036017415.1  sorting nexin-32 isoform X3

      Conserved Domains (2) summary
      cd07621
      Location:62 → 274
      BAR_SNX5_6; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexins 5 and 6
      cl02563
      Location:1 → 45
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    6. XM_036161521.1 → XP_036017414.1  sorting nexin-32 isoform X2

      Conserved Domains (2) summary
      cl02563
      Location:1 → 45
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
      cl12013
      Location:62 → 186
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RNA

    1. XR_388254.5 RNA Sequence

    2. XR_004940135.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80ZJ7.1 GenPept UniProtKB/Swiss-Prot:Q80ZJ7

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