Il31 interleukin 31 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il31provided by MGI
Official Full Name: interleukin 31provided by MGI
Primary source: MGI:MGI:1923649
See related: Ensembl:ENSMUSG00000029437 AllianceGenome:MGI:1923649
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1700013B14Rik
Summary: Enables cytokine activity and oncostatin-M receptor binding activity. Predicted to be involved in immune system process and signal transduction. Located in extracellular space. Orthologous to human IL31 (interleukin 31). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward testis adult (RPKM 17.4) See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 63.0 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (123618215..123620686, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (123480152..123482623, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IL-31-dependent neurogenic inflammation restrains cutaneous type 2 immune response in allergic dermatitis.
Title: IL-31-dependent neurogenic inflammation restrains cutaneous type 2 immune response in allergic dermatitis.
Adenosine induces IL-31 secretion by T-helper 2 cells: Implication for the effect of adenosine on atopic dermatitis and its therapeutic strategy.
Title: Adenosine induces IL-31 secretion by T-helper 2 cells: Implication for the effect of adenosine on atopic dermatitis and its therapeutic strategy.
Targeted inhibition of EPAS1-driven IL-31 production by a small-molecule compound.
Title: Targeted inhibition of EPAS1-driven IL-31 production by a small-molecule compound.
IL-31 transgenic mice show reduced allergen-induced lung inflammation.
Title: IL-31 transgenic mice show reduced allergen-induced lung inflammation.
The Cytokine TGF-beta Induces Interleukin-31 Expression from Dermal Dendritic Cells to Activate Sensory Neurons and Stimulate Wound Itching.
Title: The Cytokine TGF-β Induces Interleukin-31 Expression from Dermal Dendritic Cells to Activate Sensory Neurons and Stimulate Wound Itching.
The available data show that IL-31 is strongly linked with chronic pruritic skin disorders, such as atopic eczema, and represents a novel target for directed drug therapy.
Title: IL-31: A new key player in dermatology and beyond.
beta2-microglobulin and interleukin-31 are involved in itching associated with CRF-induced pruritus.
Title: β2-Microglobulin, interleukin-31, and arachidonic acid metabolites (leukotriene B(4) and thromboxane A(2)) are involved in chronic renal failure-associated itch-associated responses in mice.
Atopic dermatitis linked cytokine interleukin-31 induced itch is mediated via a NPPB pathway.
Title: Atopic Dermatitis Linked Cytokine Interleukin-31 Induced Itch Mediated via a Neuropeptide Natriuretic Polypeptide B.
The serum levels of IL-33 and IL-31 were significantly up-regulated in both AR and allergic asthma patients compared with normal individuals.
Title: Serum levels of IL-31, IL-33 and ST2 in allergic rhinitis of children in China.
EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction in CD4-positive T cells.
Title: The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (5) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IDA Inferred from Direct Assay more info	PubMed
enables cytokine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables oncostatin-M receptor binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in immune system process	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: interleukin-31

Names: IL-31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.