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    Fbxw14 F-box and WD-40 domain protein 14 [ Mus musculus (house mouse) ]

    Gene ID: 50757, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fbxw14provided by MGI
    Official Full Name
    F-box and WD-40 domain protein 14provided by MGI
    Primary source
    MGI:MGI:1354703
    See related
    Ensembl:ENSMUSG00000105589 AllianceGenome:MGI:1354703
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fbx12; Fbxo12; E330009N23Rik
    Summary
    Predicted to be active in cytoplasm. Orthologous to human FBXW12 (F-box and WD repeat domain containing 12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward ovary adult (RPKM 1.2) See more
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    Genomic context

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    See Fbxw14 in Genome Data Viewer
    Location:
    9 F2; 9 59.63 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (109099857..109116797, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (109270789..109287729, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene F-box and WD-40 domain protein 13 Neighboring gene F-box and WD-40 domain protein 20 Neighboring gene predicted gene, 22821 Neighboring gene F-box and WD-40 domain protein 28

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A family of mammalian F-box proteins. Winston JT, et al. Curr Biol, 1999 Oct 21. PMID 10531037
    2. Systematic analysis and nomenclature of mammalian F-box proteins. Jin J, et al. Genes Dev, 2004 Nov 1. PMID 15520277, Free PMC Article
    3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC117492

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    F-box and WD-40 domain protein 14
    Names
    F-box only protein 12
    F-box protein 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311159.1 → NP_001298088.1  F-box and WD-40 domain protein 14 isoform 2

      See identical proteins and their annotated locations for NP_001298088.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AC122308, AK087709, AK166611, CT025696
      Consensus CDS
      CCDS81079.1
      UniProtKB/TrEMBL
      B7ZN94, Q4FZL9
      Related
      ENSMUSP00000107672.5, ENSMUST00000112041.6
      Conserved Domains (1) summary
      pfam12937
      Location:4 → 48
      F-box-like; F-box-like

    2. NM_015793.2 → NP_056608.1  F-box and WD-40 domain protein 14 isoform 1

      See identical proteins and their annotated locations for NP_056608.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC122308, CT025696
      Consensus CDS
      CCDS23550.1
      UniProtKB/TrEMBL
      B9EHJ2, Q8C2Y5
      Related
      ENSMUSP00000143404.2, ENSMUST00000198844.5
      Conserved Domains (2) summary
      COG2319
      Location:99 → 316
      WD40; WD40 repeat [General function prediction only]
      pfam12937
      Location:4 → 48
      F-box-like; F-box-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      109099857..109116797 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512182.4 → XP_006512245.1  F-box and WD-40 domain protein 14 isoform X4

      UniProtKB/TrEMBL
      B9EHJ2
      Conserved Domains (1) summary
      pfam12937
      Location:4 → 46
      F-box-like

    2. XM_017313457.2 → XP_017168946.1  F-box and WD-40 domain protein 14 isoform X3

      UniProtKB/TrEMBL
      B7ZN94
      Conserved Domains (1) summary
      pfam12937
      Location:4 → 46
      F-box-like

    3. XM_017313456.2 → XP_017168945.1  F-box and WD-40 domain protein 14 isoform X2

      UniProtKB/TrEMBL
      B7ZN94
      Conserved Domains (2) summary
      COG2319
      Location:98 → 234
      WD40; WD40 repeat [General function prediction only]
      pfam12937
      Location:4 → 46
      F-box-like

    4. XM_017313455.1 → XP_017168944.1  F-box and WD-40 domain protein 14 isoform X1

      UniProtKB/TrEMBL
      B9EHJ2
      Conserved Domains (1) summary
      pfam12937
      Location:4 → 46
      F-box-like
    Nucleotide Protein Strain
    Heading Accession and Version

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