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    Csgalnact2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 [ Mus musculus (house mouse) ]

    Gene ID: 78752, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Csgalnact2provided by MGI
    Official Full Name
    chondroitin sulfate N-acetylgalactosaminyltransferase 2provided by MGI
    Primary source
    MGI:MGI:1926002
    See related
    Ensembl:ENSMUSG00000042042 AllianceGenome:MGI:1926002
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Galnact2; 4632415D10Rik
    Summary
    Enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity. Involved in chondroitin sulfate biosynthetic process. Acts upstream of or within chondroitin sulfate proteoglycan biosynthetic process. Is active in Golgi apparatus. Is expressed in brain; cartilage; knee; and limb long bone. Orthologous to human CSGALNACT2 (chondroitin sulfate N-acetylgalactosaminyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 6.5), lung adult (RPKM 4.1) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Csgalnact2 in Genome Data Viewer
    Location:
    6 F1; 6 55.86 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (118084413..118116132, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (118107452..118139140, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38884 Neighboring gene Lasp1 pseudogene Neighboring gene RasGEF domain family, member 1A Neighboring gene STARR-seq mESC enhancer starr_17132 Neighboring gene STARR-seq mESC enhancer starr_17134 Neighboring gene microRNA 7044 Neighboring gene predicted gene, 23908 Neighboring gene STARR-positive B cell enhancer ABC_E6475 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:118117270-118117379 Neighboring gene STARR-positive B cell enhancer ABC_E2800 Neighboring gene ret proto-oncogene Neighboring gene STARR-seq mESC enhancer starr_17135 Neighboring gene RIKEN cDNA 1700069P05 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Chondroitin Sulfate N-acetylgalactosaminyltransferase-2 Impacts Foam Cell Formation and Atherosclerosis by Altering Macrophage Glycosaminoglycan Chain. Adhikara IM, et al. Arterioscler Thromb Vasc Biol, 2021 Mar. PMID 33504177
    2. Chondroitin sulfate N-acetylgalactosaminyltransferase-2 deletion alleviates lipoprotein retention in early atherosclerosis and attenuates aortic smooth muscle cell migration. Adhikara IM, et al. Biochem Biophys Res Commun, 2019 Jan 29. PMID 30579596
    3. GlcUAβ1-3Galβ1-3Galβ1-4Xyl(2-O-phosphate) is the preferred substrate for chondroitin N-acetylgalactosaminyltransferase-1. Izumikawa T, et al. J Biol Chem, 2015 Feb 27. PMID 25568321, Free PMC Article
    4. Chondroitin sulphate N-acetylgalactosaminyl-transferase-1 inhibits recovery from neural injury. Takeuchi K, et al. Nat Commun, 2013. PMID 24220492, Free PMC Article
    5. Chondroitin 4-O-sulfotransferase-1 regulates the chain length of chondroitin sulfate in co-operation with chondroitin N-acetylgalactosaminyltransferase-2. Izumikawa T, et al. Biochem J, 2011 Mar 1. PMID 21138417

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Chondroitin Sulfate N-acetylgalactosaminyltransferase-2 Impacts Foam Cell Formation and Atherosclerosis by Altering Macrophage Glycosaminoglycan Chain.
      Title: Chondroitin Sulfate N-acetylgalactosaminyltransferase-2 Impacts Foam Cell Formation and Atherosclerosis by Altering Macrophage Glycosaminoglycan Chain.
    2. Chondroitin sulfate N-acetylgalactosaminyltransferase 2 is functionally involved in the progression of atherosclerosis both in its early and advanced stages.
      Title: Chondroitin sulfate N-acetylgalactosaminyltransferase-2 deletion alleviates lipoprotein retention in early atherosclerosis and attenuates aortic smooth muscle cell migration.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (4)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acetylgalactosaminyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acetylgalactosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables acetylgalactosaminyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chondroitin sulfate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chondroitin sulfate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within chondroitin sulfate proteoglycan biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in chondroitin sulfate proteoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dermatan sulfate proteoglycan biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dermatan sulfate proteoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteoglycan biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    chondroitin sulfate N-acetylgalactosaminyltransferase 2
    Names
    beta4GalNAcT-2
    chondroitin beta-1,4-N-acetylgalactosaminyltransferase 2
    chondroitin sulfate GalNAcT-2
    galNAcT-2
    NP_001349078.1
    NP_084441.3
    XP_006506840.1
    XP_036008295.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362149.1 → NP_001349078.1  chondroitin sulfate N-acetylgalactosaminyltransferase 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC135861
      Consensus CDS
      CCDS20469.1
      UniProtKB/Swiss-Prot
      Q6PAP6, Q8C1F4, Q8R5A2, Q9D2M1
      Conserved Domains (1) summary
      cl11394
      Location:75 → 516
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    2. NM_030165.3 → NP_084441.3  chondroitin sulfate N-acetylgalactosaminyltransferase 2

      See identical proteins and their annotated locations for NP_084441.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AK019496, AK028045, BC060169
      Consensus CDS
      CCDS20469.1
      UniProtKB/Swiss-Prot
      Q6PAP6, Q8C1F4, Q8R5A2, Q9D2M1
      Related
      ENSMUSP00000039819.9, ENSMUST00000049344.15
      Conserved Domains (1) summary
      cl11394
      Location:75 → 516
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      118084413..118116132 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152402.1 → XP_036008295.1  chondroitin sulfate N-acetylgalactosaminyltransferase 2 isoform X2

      Conserved Domains (1) summary
      cl11394
      Location:67 → 482
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    2. XM_006506777.5 → XP_006506840.1  chondroitin sulfate N-acetylgalactosaminyltransferase 2 isoform X1

      See identical proteins and their annotated locations for XP_006506840.1

      UniProtKB/Swiss-Prot
      Q6PAP6, Q8C1F4, Q8R5A2, Q9D2M1
      Conserved Domains (1) summary
      cl11394
      Location:75 → 516
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C1F4.1 GenPept UniProtKB/Swiss-Prot:Q8C1F4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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