Foxh1 forkhead box H1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Foxh1provided by MGI
Official Full Name: forkhead box H1provided by MGI
Primary source: MGI:MGI:1347465
See related: Ensembl:ENSMUSG00000033837 AllianceGenome:MGI:1347465
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fast1; Fast2; fast-1; fast-2
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; R-SMAD binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including heart morphogenesis; regulation of transcription by RNA polymerase II; and transforming growth factor beta receptor signaling pathway. Acts upstream of or within axial mesoderm development; regionalization; and regulation of transcription by RNA polymerase II. Located in nucleus. Part of activin responsive factor complex. Is expressed in several structures, including early conceptus; embryo ectoderm; embryo mesoderm; lung; and ovary. Used to study agnathia-otocephaly complex and visceral heterotaxy. Orthologous to human FOXH1 (forkhead box H1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in cortex adult (RPKM 16.4), frontal lobe adult (RPKM 12.1) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 D3; 15 36.24 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (76552029..76554286, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (76667829..76671614, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FOXH1 was identified as a critical mediator of mutant p53 function that binds to and regulates stem cell-associated genes and transcriptional programs in the context of mouse model of acute myeloid leukemia.
Title: A Gain-of-Function p53-Mutant Oncogene Promotes Cell Fate Plasticity and Myeloid Leukemia through the Pluripotency Factor FOXH1.
that FAST2 is expressed in a cell-specific manner during ovarian follicle development
Title: Expression and distribution of forkhead activin signal transducer 2 (FAST2) during follicle development in mouse ovaries and pre-implantation embryos.
The finding that Foxh1-Grg-mediated repression is not essential for Nodal expression during mouse embryogenesis suggests that other regulators compensate for the loss of repressive regulatory input that is mediated by Grg interactions.
Title: Disrupting Foxh1-Groucho interaction reveals robustness of nodal-based embryonic patterning.
Formation of midgut and hindgut definitive endoderm is unaffected by loss of Foxh1 or Foxa2.
Title: Foxh1 and Foxa2 are not required for formation of the midgut and hindgut definitive endoderm.
Foxh1 initiates a transcriptional regulatory network within the developing anterior neuroectoderm.
Title: Genome-wide identification of Smad/Foxh1 targets reveals a role for Foxh1 in retinoic acid regulation and forebrain development.
As goosecoid is itself induced in a Foxh1-dependent manner, we propose that Foxh1 initiates positive and negative transcriptional circuits to refine cell fate decisions during gastrulation
Title: Foxh1 recruits Gsc to negatively regulate Mixl1 expression during early mouse development.
A conserved intronic enhancer (ASE), containing binding sites for the fork head transcription factor Foxh1, modulates dynamic patterns of Nodal expression during early mouse development.
Title: The Foxh1-dependent autoregulatory enhancer controls the level of Nodal signals in the mouse embryo.
Foxh1 and Nkx2-5 functionally interact and are essential for development of the anterior heart field and its derivatives
Title: Foxh1 is essential for development of the anterior heart field.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (1)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC313795P1 (e-PCR)
- UniSTS:272926

Foxh1 (e-PCR), detects polymorphism
- UniSTS:143136

NoName (e-PCR)
- UniSTS:491228

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables R-SMAD binding	IDA Inferred from Direct Assay more info	PubMed
enables R-SMAD binding	ISO Inferred from Sequence Orthology more info
enables SMAD binding	IPI Inferred from Physical Interaction more info	PubMed
enables SMAD binding	ISO Inferred from Sequence Orthology more info
enables bHLH transcription factor binding	IEA Inferred from Electronic Annotation more info
enables bHLH transcription factor binding	ISO Inferred from Sequence Orthology more info
enables co-SMAD binding	IEA Inferred from Electronic Annotation more info
enables co-SMAD binding	ISO Inferred from Sequence Orthology more info
enables nuclear androgen receptor binding	IEA Inferred from Electronic Annotation more info
enables nuclear androgen receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within anterior/posterior pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in aorta morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axial mesoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac right ventricle morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to cytokine stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cytokine stimulus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic heart tube anterior/posterior pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart looping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hepatocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of androgen receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of androgen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intracellular estrogen receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of intracellular estrogen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in outflow tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in secondary heart field specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transforming growth factor beta receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in transforming growth factor beta receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventricular trabecula myocardium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of activin responsive factor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of activin responsive factor complex	IDA Inferred from Direct Assay more info	PubMed
part_of activin responsive factor complex	ISO Inferred from Sequence Orthology more info
located_in chromatin	IEA Inferred from Electronic Annotation more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: forkhead box protein H1

Names: FAST1 transcription factor; forkhead activin signal transducer 1; forkhead activin signal transducer 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007989.4 → NP_032015.1 forkhead box protein H1

See identical proteins and their annotated locations for NP_032015.1

Status: VALIDATED

Source sequence(s)

AC156550, BC119156

Consensus CDS

CCDS27584.1

UniProtKB/Swiss-Prot

O88621, Q9QZL5, Q9R241

UniProtKB/TrEMBL

Q0VEP8

Related

ENSMUSP00000036591.5, ENSMUST00000037824.6

Conserved Domains (1) summary

cd00059
Location:64 → 142

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

76552029..76554286 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006520436.5 → XP_006520499.1 forkhead box protein H1 isoform X1

See identical proteins and their annotated locations for XP_006520499.1

UniProtKB/Swiss-Prot

O88621

Conserved Domains (1) summary

cd00059
Location:64 → 138

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...