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    Aurkaip1 aurora kinase A interacting protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 66077, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Aurkaip1provided by MGI
    Official Full Name
    aurora kinase A interacting protein 1provided by MGI
    Primary source
    MGI:MGI:1913327
    See related
    Ensembl:ENSMUSG00000065990 AllianceGenome:MGI:1913327
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Aip; Akip; MRP-S38; 0610033H09Rik
    Summary
    Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in positive regulation of proteolysis and protein ubiquitination. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human AURKAIP1 (aurora kinase A interacting protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 84.4), duodenum adult (RPKM 60.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Aurkaip1 in Genome Data Viewer
    Location:
    4 E2; 4 87.55 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (155915709..155917555)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (155831269..155833098)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L20 Neighboring gene STARR-positive B cell enhancer ABC_E3560 Neighboring gene cyclin L2 Neighboring gene STARR-seq mESC enhancer starr_12275 Neighboring gene STARR-positive B cell enhancer ABC_E4740 Neighboring gene STARR-positive B cell enhancer ABC_E8042 Neighboring gene STARR-positive B cell enhancer ABC_E10297 Neighboring gene matrix-remodelling associated 8 Neighboring gene dishevelled segment polarity protein 1 Neighboring gene taste receptor, type 1, member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Aurora-A kinase interacting protein (AIP), a novel negative regulator of human Aurora-A kinase. Kiat LS, et al. J Biol Chem, 2002 Nov 22. PMID 12244051
    2. Positional cloning of the mouse saccharin preference (Sac) locus. Bachmanov AA, et al. Chem Senses, 2001 Sep. PMID 11555487, Free PMC Article
    3. Ribosome. The structure of the human mitochondrial ribosome. Amunts A, et al. Science, 2015 Apr 3. PMID 25838379, Free PMC Article
    4. TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation. Fan X, et al. Elife, 2021 Feb 8. PMID 33554859, Free PMC Article
    5. Aurora-A kinase interacting protein 1 (AURKAIP1) promotes Aurora-A degradation through an alternative ubiquitin-independent pathway. Lim SK, et al. Biochem J, 2007 Apr 1. PMID 17125467, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. There exists an Ub-independent alternative pathway that promotesAurora-A degradation and AURKAIP1 promotes Aurora-A degradation through this Ub-independent yet proteasome-dependent pathway.
      Title: Aurora-A kinase interacting protein 1 (AURKAIP1) promotes Aurora-A degradation through an alternative ubiquitin-independent pathway.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    contributes_to ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of anaphase-promoting complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of mitochondrial small ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    small ribosomal subunit protein mS38
    Names
    28S ribosomal protein S38, mitochondrial
    AURKA-interacting protein
    Aurora-A kinase interacting protein
    aurora kinase A-interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025338.4 → NP_079614.1  small ribosomal subunit protein mS38

      Status: VALIDATED

      Source sequence(s)
      AK003442, AL670236, CX233396
      Consensus CDS
      CCDS19043.1
      UniProtKB/Swiss-Prot
      Q9D1J7, Q9DCJ7
      UniProtKB/TrEMBL
      Q3TZ21, Q8CCC0
      Related
      ENSMUSP00000081114.6, ENSMUST00000084097.12
      Conserved Domains (1) summary
      pfam08213
      Location:128 → 160
      DUF1713; Mitochondrial domain of unknown function (DUF1713)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      155915709..155917555
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539095.4 → XP_006539158.1  small ribosomal subunit protein mS38 isoform X1

      UniProtKB/Swiss-Prot
      Q9D1J7, Q9DCJ7
      UniProtKB/TrEMBL
      Q3TZ21, Q8CCC0
      Related
      ENSMUSP00000101216.2, ENSMUST00000105591.2
      Conserved Domains (1) summary
      pfam08213
      Location:128 → 160
      DUF1713; Mitochondrial domain of unknown function (DUF1713)

    2. XM_036164304.1 → XP_036020197.1  small ribosomal subunit protein mS38 isoform X1

      UniProtKB/Swiss-Prot
      Q9D1J7, Q9DCJ7
      UniProtKB/TrEMBL
      Q3TZ21, Q8CCC0
      Related
      ENSMUSP00000101217.2, ENSMUST00000105592.8
      Conserved Domains (1) summary
      pfam08213
      Location:128 → 160
      DUF1713; Mitochondrial domain of unknown function (DUF1713)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DCJ7.2 GenPept UniProtKB/Swiss-Prot:Q9DCJ7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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