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    Fmn1 formin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296512, updated on 9-Dec-2024

    Summary

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    Symbol
    Fmn1provided by RGD
    Full Name
    formin 1provided by RGD
    Primary source
    RGD:1306349
    See related
    EnsemblRapid:ENSRNOG00000031760 AllianceGenome:RGD:1306349
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306349; RGD1310100
    Summary
    Predicted to enable SH3 domain binding activity. Predicted to be involved in actin nucleation. Predicted to act upstream of or within several processes, including limb morphogenesis; positive regulation of cellular component organization; and ureteric bud invasion. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human FMN1 (formin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 68.4), Brain (RPKM 49.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fmn1 in Genome Data Viewer
    Location:
    3q35
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (120555445..120939978)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (100101103..100485652)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (104783093..105170761)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101626 Neighboring gene WD repeat domain 12, pseudogene 1 Neighboring gene transmembrane and coiled-coil domains 5B Neighboring gene large ribosomal subunit protein eL33-like Neighboring gene twinfilin-2-like Neighboring gene mRNA turnover 4, ribosome maturation factor, pseudogene 4 Neighboring gene sorbitol dehydrogenase, pseudogene 5 Neighboring gene gremlin 1, DAN family BMP antagonist

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Formin 1 Regulates Microtubule and F-Actin Organization to Support Spermatid Transport During Spermatogenesis in the Rat Testis. Li N, et al. Endocrinology, 2016 Jul. PMID 27145014, Free PMC Article
    2. Formin 1 Regulates Ectoplasmic Specialization in the Rat Testis Through Its Actin Nucleation and Bundling Activity. Li N, et al. Endocrinology, 2015 Aug. PMID 25901598, Free PMC Article
    3. Formin 1-isoform IV deficient cells exhibit defects in cell spreading and focal adhesion formation. Dettenhofer M, et al. PLoS One, 2008 Jun 18. PMID 18560567, Free PMC Article
    4. Actin coating and compression of fused secretory vesicles are essential for surfactant secretion--a role for Rho, formins and myosin II. Miklavc P, et al. J Cell Sci, 2012 Jun 1. PMID 22427691
    5. Formin-1 protein associates with microtubules through a peptide domain encoded by exon-2. Zhou F, et al. Exp Cell Res, 2006 Apr 15. PMID 16480715

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In summary, formin1 maintains MT and F-actin track-like structures to support spermatid and phagosome transport across the seminiferous epithelium during spermatogenesis.
      Title: Formin 1 Regulates Microtubule and F-Actin Organization to Support Spermatid Transport During Spermatogenesis in the Rat Testis.
    2. Formin 1 is a regulator of ectoplasmic specialization dynamics in the testis.
      Title: Formin 1 Regulates Ectoplasmic Specialization in the Rat Testis Through Its Actin Nucleation and Bundling Activity.
    3. Initial actin coating of fused vesicles is dependent on activation of Rho and formin-dependent actin nucleation. Actin coat contraction is facilitated by myosin II.
      Title: Actin coating and compression of fused secretory vesicles are essential for surfactant secretion--a role for Rho, formins and myosin II.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin nucleation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within forelimb morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within hindlimb morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within limb development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of actin nucleation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within skeletal system morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ureteric bud invasion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in actin filament IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    formin 1; formin-1
    Names
    mRNA turnover protein 4 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      120555445..120939978
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285290.1 → XP_063141360.1  formin-1 isoform X4

    2. XM_039106467.2 → XP_038962395.1  formin-1 isoform X1

      UniProtKB/TrEMBL
      D4A4Y9
      Related
      ENSRNOP00000042712.6, ENSRNOT00000042103.6
      Conserved Domains (1) summary
      smart00498
      Location:983 → 1380
      FH2; Formin Homology 2 Domain

    3. XM_063285289.1 → XP_063141359.1  formin-1 isoform X2

      UniProtKB/TrEMBL
      D4A4Y9, D4A7C2
      Related
      ENSRNOP00000047506.6, ENSRNOT00000044625.7

    4. XM_063285292.1 → XP_063141362.1  formin-1 isoform X6

      UniProtKB/TrEMBL
      A6HP62

    5. XM_063285293.1 → XP_063141363.1  formin-1 isoform X7

      UniProtKB/TrEMBL
      A6HP62

    6. XM_039106466.2 → XP_038962394.1  formin-1 isoform X1

      UniProtKB/TrEMBL
      D4A4Y9
      Conserved Domains (1) summary
      smart00498
      Location:983 → 1380
      FH2; Formin Homology 2 Domain

    7. XM_063285291.1 → XP_063141361.1  formin-1 isoform X4

    8. XM_039106468.2 → XP_038962396.1  formin-1 isoform X1

      UniProtKB/TrEMBL
      D4A4Y9
      Conserved Domains (1) summary
      smart00498
      Location:983 → 1380
      FH2; Formin Homology 2 Domain

    9. XM_039106472.2 → XP_038962400.1  formin-1 isoform X5

      UniProtKB/TrEMBL
      A0A8I6GJL6
      Related
      ENSRNOP00000091414.1, ENSRNOT00000114830.2
      Conserved Domains (1) summary
      smart00498
      Location:371 → 768
      FH2; Formin Homology 2 Domain

    10. XM_039106470.2 → XP_038962398.1  formin-1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AHH7, D3ZBI5
      Related
      ENSRNOP00000094328.1, ENSRNOT00000098989.2
      Conserved Domains (2) summary
      smart00498
      Location:759 → 1156
      FH2; Formin Homology 2 Domain
      PHA03169
      Location:61 → 240
      PHA03169; hypothetical protein; Provisional

    11. XM_039106474.2 → XP_038962402.1  formin-1 isoform X8

      Conserved Domains (1) summary
      smart00498
      Location:198 → 595
      FH2; Formin Homology 2 Domain
    Nucleotide Protein Strain
    Heading Accession and Version

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