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    SUN1 SAD1/UNC-84 domain protein 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830381, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SUN1
    Official Full Name
    SAD1/UNC-84 domain protein 1
    Primary source
    TAIR:AT5G04990
    Locus tag
    AT5G04990
    See related
    Araport:AT5G04990
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS SAD1/UNC-84 DOMAIN PROTEIN 1; ATSUN1; MUG13.15; MUG13_15; SAD1/UNC-84 domain protein 1
    Summary
    Encodes a member of the Sad1/UNC-84 (SUN)-domain proteins: AtSUN1(At5g04990), AtSUN2(AT3G10730). SUN domain proteins are part of the cytoskeletal-nucleoskeletal bridging complexes. AtSUN1 and AtSUN2 are localized to the nuclear envelope and are present as homomers and heteromers in vivo.Encodes an outer nuclear membrane protein that anchors RanGAP1 to the nuclear envelope. It interacts with WPP domain interacting-proteins (WIPs). It is involved in maintaining the elongated nuclear shape of epidermal cells.
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    Genomic context

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    See SUN1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    2
    Sequence:
    Chromosome: 5; NC_003076.8 (1471481..1474029, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Plant invertase/pectin methylesterase inhibitor superfamily Neighboring gene DNAse I-like superfamily protein Neighboring gene translocon at the outer envelope membrane of chloroplasts 34 Neighboring gene clathrin adaptor complexes medium subunit family protein Neighboring gene Pollen Ole e 1 allergen and extensin family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of SUN-domain proteins at the higher plant nuclear envelope. Graumann K, et al. Plant J, 2010 Jan. PMID 19807882
    2. Dynamics of Arabidopsis SUN proteins during mitosis and their involvement in nuclear shaping. Oda Y, et al. Plant J, 2011 May. PMID 21294795
    3. Absence of SUN1 and SUN2 proteins in Arabidopsis thaliana leads to a delay in meiotic progression and defects in synapsis and recombination. Varas J, et al. Plant J, 2015 Jan. PMID 25412930
    4. Evidence for LINC1-SUN associations at the plant nuclear periphery. Graumann K. PLoS One, 2014. PMID 24667841, Free PMC Article
    5. SUN anchors pollen WIP-WIT complexes at the vegetative nuclear envelope and is necessary for pollen tube targeting and fertility. Zhou X, et al. J Exp Bot, 2015 Dec. PMID 26409047, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the role that SUN proteins may play in pollen nuclear migration
      Title: SUN anchors pollen WIP-WIT complexes at the vegetative nuclear envelope and is necessary for pollen tube targeting and fertility.
    2. The nuclear envelope localization of SUN1, SUN2, WIP1, and a truncated WIT2 does not depend on CRWN1.
      Title: Plant nuclear shape is independently determined by the SUN-WIP-WIT2-myosin XI-i complex and CRWN1.
    3. associations between AtLINC1 and plant SUN proteins
      Title: Evidence for LINC1-SUN associations at the plant nuclear periphery.
    4. SUN1 and SUN2 are necessary for the maintenance and/or formation of polarized nuclear shape in root hairs.
      Title: Dynamics of Arabidopsis SUN proteins during mitosis and their involvement in nuclear shaping.
    5. Results indicate that AtSUN1 contain the highly conserved C-terminal SUN domain, localize to and show low mobility in the nuclear envelope (NE), particularly in the inner nuclear membrane.
      Title: Characterization of SUN-domain proteins at the higher plant nuclear envelope.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_120581.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-membrane adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in meiotic attachment of telomere to nuclear envelope IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within nucleus organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within nucleus organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleus organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein heterooligomerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein homooligomerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein localization to nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein localization to nuclear envelope IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of establishment or maintenance of cell polarity regulating cell shape IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope HDA PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in phragmoplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SAD1/UNC-84 domain protein 1
    NP_196118.1
    • SAD1/UNC-84 domain protein 1 (SUN1); FUNCTIONS IN: protein binding; INVOLVED IN: biological_process unknown; LOCATED IN: nuclear envelope, endoplasmic reticulum; EXPRESSED IN: inflorescence, cultured cell, callus, leaf; CONTAINS InterPro DOMAIN/s: Sad1/UNC-like, C-terminal (InterPro:IPR012919); BEST Arabidopsis thaliana protein match is: SAD1/UNC-84 domain protein 2 (TAIR:AT3G10730.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      1471481..1474029 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_120581.5 → NP_196118.1  SAD1/UNC-84 domain protein 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196118.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FF75
      UniProtKB/TrEMBL
      A0A5S9Y3P4, A0A654FYD6
      Conserved Domains (2) summary
      COG1196
      Location:153 → 275
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07738
      Location:313 → 450
      Sad1_UNC; Sad1 / UNC-like C-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FF75.1

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