Large1 LARGE xylosyl- and glucuronyltransferase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Large1provided by RGD
Official Full Name: LARGE xylosyl- and glucuronyltransferase 1provided by RGD
Primary source: RGD:1308895
See related: EnsemblRapid:ENSRNOG00000013742 AllianceGenome:RGD:1308895
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Large
Summary: Predicted to enable glucuronosyltransferase activity; manganese ion binding activity; and xylosyltransferase activity. Predicted to be involved in muscle cell cellular homeostasis; protein O-linked mannosylation; and skeletal muscle organ development. Predicted to act upstream of or within several processes, including nervous system development; retina development in camera-type eye; and striated muscle cell differentiation. Predicted to be located in Golgi membrane. Predicted to be part of protein-containing complex. Predicted to be active in Golgi apparatus; neuromuscular junction; and plasma membrane. Human ortholog(s) of this gene implicated in congenital muscular dystrophy-dystroglycanopathy type A6 and muscular dystrophy-dystroglycanopathy type B6. Orthologous to human LARGE1 (LARGE xylosyl- and glucuronyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 195.2), Lung (RPKM 103.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19p12-p11

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (11609004..12057174, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (11603129..12048930, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (12481563..12945320, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

D19Got2 (e-PCR)
- UniSTS:115524

d19rat82 (e-PCR)
- UniSTS:121426

BF387307 (e-PCR)
- UniSTS:244312

RH137652 (e-PCR)
- UniSTS:219739

RH137727 (e-PCR)
- UniSTS:219814

BF400276 (e-PCR)
- UniSTS:244908

BF399122 (e-PCR)
- UniSTS:247536

BM388355 (e-PCR)
- UniSTS:261631

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables glucuronosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucuronosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables glycosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables hexosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables manganese ion binding	ISO Inferred from Sequence Orthology more info
enables xylosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables xylosyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within acetylcholine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within astrocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within basement membrane organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within behavioral fear response	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within blood vessel development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within bone development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within brain development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac muscle tissue development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within connective tissue development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cytoskeleton organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dentate gyrus development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within determination of adult lifespan	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glycoprotein biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glycoprotein metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular protein transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within limb development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within localization of cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within macrophage differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within memory	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in muscle cell cellular homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within muscle organ development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myelination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myotube differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nerve development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuromuscular junction development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuromuscular process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuromuscular process controlling posture	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuromuscular synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within plasma membrane organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-embryonic hindlimb morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-translational protein modification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within principal sensory nucleus of trigeminal nerve development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein O-linked glycosylation	ISO Inferred from Sequence Orthology more info
involved_in protein O-linked mannosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein O-linked mannosylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein deglycosylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein glycosylation	ISO Inferred from Sequence Orthology more info
involved_in protein glycosylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization to membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein modification process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein targeting to membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within reactive gliosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of kinase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of synaptic plasticity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to light stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to mechanical stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retina development in camera-type eye	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retina layer formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retina vasculature development in camera-type eye	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sensory perception of sound	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal muscle fiber development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal muscle fiber differentiation	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle organ development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal muscle tissue regeneration	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle tissue regeneration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within striated muscle cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within striated muscle contraction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within synapse organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within synaptic assembly at neuromuscular junction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within walking behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within water transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in neuromuscular junction	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: xylosyl- and glucuronyltransferase LARGE1

Names: glycosyltransferase-like protein LARGE1; like-glycosyltransferase

XP_063134175.1

EC 2.4.1.-

XP_063134176.1

EC 2.4.1.-

XP_063134177.1

EC 2.4.1.-

XP_063134178.1

EC 2.4.1.-

XP_063134179.1

EC 2.4.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429166.1 → NP_001416095.1 xylosyl- and glucuronyltransferase LARGE1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/TrEMBL

A0A0G2K618
NM_001429167.1 → NP_001416096.1 xylosyl- and glucuronyltransferase LARGE1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/TrEMBL

A0A0G2K618
NM_001429168.1 → NP_001416097.1 xylosyl- and glucuronyltransferase LARGE1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/TrEMBL

A0A0G2K618

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

11609004..12057174 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063278109.1 → XP_063134179.1 xylosyl- and glucuronyltransferase LARGE1 isoform X1
XM_063278105.1 → XP_063134175.1 xylosyl- and glucuronyltransferase LARGE1 isoform X1

Related

ENSRNOP00000073641.3, ENSRNOT00000090886.3
XM_063278108.1 → XP_063134178.1 xylosyl- and glucuronyltransferase LARGE1 isoform X1
XM_063278106.1 → XP_063134176.1 xylosyl- and glucuronyltransferase LARGE1 isoform X1

UniProtKB/TrEMBL

A0A0G2K618
XM_063278107.1 → XP_063134177.1 xylosyl- and glucuronyltransferase LARGE1 isoform X1

UniProtKB/TrEMBL

A0A0G2K618

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001108439.1: Suppressed sequence

Description

NM_001108439.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.