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    Scrn3 secernin 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311731, updated on 9-Dec-2024

    Summary

    Official Symbol
    Scrn3provided by RGD
    Official Full Name
    secernin 3provided by RGD
    Primary source
    RGD:1305064
    See related
    EnsemblRapid:ENSRNOG00000018657 AllianceGenome:RGD:1305064
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cysteine-type exopeptidase activity and dipeptidase activity. Predicted to be involved in proteolysis. Orthologous to human SCRN3 (secernin 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 139.0), Heart (RPKM 129.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Scrn3 in Genome Data Viewer
    Location:
    3q23
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (78596330..78621132)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (58188820..58213623)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (60023970..60048746)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene Sp9 transcription factor Neighboring gene corepressor interacting with RBPJ, 1 Neighboring gene G protein-coupled receptor 155 Neighboring gene uncharacterized LOC134486289

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399566.1NP_001386495.1  secernin-3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A0G2K189, A6HM88, G3V8F4, Q5I0K6
      Related
      ENSRNOP00000071745.1, ENSRNOT00000081881.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      78596330..78621132
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006234360.5XP_006234422.1  secernin-3 isoform X2

      See identical proteins and their annotated locations for XP_006234422.1

      UniProtKB/TrEMBL
      G3V8F4, Q5I0K6
      Related
      ENSRNOP00000025255.6, ENSRNOT00000025255.8
      Conserved Domains (1) summary
      cl00467
      Location:5224
      Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
    2. XM_039105165.2XP_038961093.2  secernin-3 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A9K3
    3. XM_063283911.1XP_063139981.1  secernin-3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K189, A6HM88, G3V8F4, Q5I0K6
    4. XM_039105164.2XP_038961092.1  secernin-3 isoform X3

      UniProtKB/TrEMBL
      A6HM89

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001013162.1: Suppressed sequence

      Description
      NM_001013162.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.