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    Erg ETS transcription factor ERG [ Rattus norvegicus (Norway rat) ]

    Gene ID: 170909, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ergprovided by RGD
    Official Full Name
    ETS transcription factor ERGprovided by RGD
    Primary source
    RGD:621108
    See related
    EnsemblRapid:ENSRNOG00000001652 AllianceGenome:RGD:621108
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Predicted to be involved in cell differentiation and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleus. Biomarker of pulmonary venoocclusive disease. Human ortholog(s) of this gene implicated in hereditary lymphedema and myeloid leukemia. Orthologous to human ERG (ETS transcription factor ERG). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 124.0), Heart (RPKM 53.9) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Erg in Genome Data Viewer
    Location:
    11q11
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (48148149..48370472, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (34678614..34900951, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (35645317..35749637, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095565 Neighboring gene uncharacterized LOC102550135 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 15 Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC120095640 Neighboring gene ETS proto-oncogene 2, transcription factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Targeting the DNA-binding activity of the human ERG transcription factor using new heterocyclic dithiophene diamidines. Nhili R, et al. Nucleic Acids Res, 2013 Jan 7. PMID 23093599, Free PMC Article
    2. Perturbation of fetal hematopoiesis in a mouse model of Down syndrome's transient myeloproliferative disorder. Birger Y, et al. Blood, 2013 Aug 8. PMID 23719302, Free PMC Article
    3. ETS-related gene (ERG) controls endothelial cell permeability via transcriptional regulation of the claudin 5 (CLDN5) gene. Yuan L, et al. J Biol Chem, 2012 Feb 24. PMID 22235125, Free PMC Article
    4. Transcription factor Erg regulates angiogenesis and endothelial apoptosis through VE-cadherin. Birdsey GM, et al. Blood, 2008 Apr 1. PMID 18195090, Free PMC Article
    5. Comparison of Human and Experimental Pulmonary Veno-Occlusive Disease. Manaud G, et al. Am J Respir Cell Mol Biol, 2020 Jul. PMID 32209028

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transcriptional regulator ERG
    Names
    ERG, ETS transcription factor
    avian erythroblastosis virus E-26 (v-ets) oncogene related
    v-ets avian erythroblastosis virus E26 oncogene
    v-ets erythroblastosis virus E26 oncogene homolog
    v-ets erythroblastosis virus E26 oncogene like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133397.2 → NP_596888.1  transcriptional regulator ERG

      See identical proteins and their annotated locations for NP_596888.1

      Status: PROVISIONAL

      Source sequence(s)
      AB031088
      UniProtKB/TrEMBL
      Q6IMZ7, Q91XV5
      Conserved Domains (2) summary
      smart00413
      Location:286 → 369
      ETS; erythroblast transformation specific domain
      cl15755
      Location:115 → 198
      SAM_superfamily; SAM (Sterile alpha motif )

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      48148149..48370472 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039087928.1 → XP_038943856.1  transcriptional regulator ERG isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZMT0, A6KPU4, Q6IMZ7
      Related
      ENSRNOP00000047414.7, ENSRNOT00000039999.8
      Conserved Domains (2) summary
      smart00413
      Location:317 → 400
      ETS; erythroblast transformation specific domain
      cl15755
      Location:122 → 205
      SAM_superfamily; SAM (Sterile alpha motif )

    2. XM_039087933.1 → XP_038943861.1  transcriptional regulator ERG isoform X7

      UniProtKB/TrEMBL
      A0A8I6A9N1, Q6IMZ7
      Related
      ENSRNOP00000090227.3, ENSRNOT00000119400.3
      Conserved Domains (2) summary
      smart00413
      Location:270 → 353
      ETS; erythroblast transformation specific domain
      cl15755
      Location:122 → 205
      SAM_superfamily; SAM (Sterile alpha motif )

    3. XM_039087931.1 → XP_038943859.1  transcriptional regulator ERG isoform X4

      UniProtKB/TrEMBL
      A6KPU6, D4A3D6, Q6IMZ7
      Related
      ENSRNOP00000105338.1, ENSRNOT00000168480.1
      Conserved Domains (2) summary
      smart00413
      Location:293 → 376
      ETS; erythroblast transformation specific domain
      cl15755
      Location:122 → 205
      SAM_superfamily; SAM (Sterile alpha motif )

    4. XM_063270253.1 → XP_063126323.1  transcriptional regulator ERG isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZKZ6, A6KPU5, Q6IMZ7
      Related
      ENSRNOP00000079399.2, ENSRNOT00000118689.3

    5. XM_039087929.2 → XP_038943857.1  transcriptional regulator ERG isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZMT0, A6KPU4, Q6IMZ7
      Conserved Domains (2) summary
      smart00413
      Location:317 → 400
      ETS; erythroblast transformation specific domain
      cl15755
      Location:122 → 205
      SAM_superfamily; SAM (Sterile alpha motif )

    6. XM_006248142.5 → XP_006248204.1  transcriptional regulator ERG isoform X2

      See identical proteins and their annotated locations for XP_006248204.1

      UniProtKB/TrEMBL
      A0A0G2JWE9, A6KPU7, Q6IMZ7
      Related
      ENSRNOP00000069853.1, ENSRNOT00000078425.4
      Conserved Domains (2) summary
      smart00413
      Location:310 → 393
      ETS; erythroblast transformation specific domain
      cl15755
      Location:115 → 198
      SAM_superfamily; SAM (Sterile alpha motif )

    7. XM_063270256.1 → XP_063126326.1  transcriptional regulator ERG isoform X8

      UniProtKB/TrEMBL
      Q6IMZ7

    8. XM_063270254.1 → XP_063126324.1  transcriptional regulator ERG isoform X5

      UniProtKB/TrEMBL
      Q6IMZ7

    9. XM_063270255.1 → XP_063126325.1  transcriptional regulator ERG isoform X6

      UniProtKB/TrEMBL
      A0A0G2JYF1

    10. XM_039087932.2 → XP_038943860.1  transcriptional regulator ERG isoform X6

      UniProtKB/TrEMBL
      A0A0G2JYF1
      Conserved Domains (2) summary
      smart00413
      Location:278 → 361
      ETS; erythroblast transformation specific domain
      cl15755
      Location:83 → 166
      SAM_superfamily; SAM (Sterile alpha motif )
    Nucleotide Protein Strain
    Heading Accession and Version

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