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    Tmprss11d transmembrane serine protease 11D [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64565, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tmprss11dprovided by RGD
    Official Full Name
    transmembrane serine protease 11Dprovided by RGD
    Primary source
    RGD:620654
    See related
    EnsemblRapid:ENSRNOG00000055991 AllianceGenome:RGD:620654
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Asp
    Summary
    Enables serine-type peptidase activity. Involved in regulation of growth. Located in cell surface. Orthologous to human TMPRSS11D (transmembrane serine protease 11D). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 14.1), Testes (RPKM 6.8) and 4 other tissues See more
    Orthologs
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    Genomic context

    See Tmprss11d in Genome Data Viewer
    Location:
    14p21
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (22062129..22124189)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (21707336..21769398)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (23330933..23392993)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene transmembrane protease, serine 11G Neighboring gene transmembrane serine protease 11A Neighboring gene U2 spliceosomal RNA Neighboring gene transmembrane protease, serine 11C Neighboring gene uncharacterized LOC103692776 Neighboring gene gonadotropin releasing hormone receptor

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in proteolysis  
    involved_in proteolysis  
    involved_in regulation of growth PubMed 
    Component Evidence Code Pubs
    located_in cell surface PubMed 
    located_in extracellular region  
    located_in plasma membrane  

    General protein information

    Preferred Names
    transmembrane protease serine 11D
    Names
    AT
    adrenal secretory serine protease
    airway trypsin-like protease
    transmembrane protease, serine 11d

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033652.2NP_001028824.2  transmembrane protease serine 11D isoform a

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/Swiss-Prot
      Q8VHJ4, Q9QZ74
      UniProtKB/TrEMBL
      A6JCR3, G3V691
      Related
      ENSRNOP00000073795.1, ENSRNOT00000088552.3
      Conserved Domains (2) summary
      cd00190
      Location:186414
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam01390
      Location:48150
      SEA; SEA domain
    2. NM_022630.2NP_072152.2  transmembrane protease serine 11D isoform b precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A6JCR4
      Conserved Domains (1) summary
      cd00190
      Location:48276
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      22062129..22124189
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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