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    Pde4dip phosphodiesterase 4D interacting protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64183, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pde4dipprovided by RGD
    Official Full Name
    phosphodiesterase 4D interacting proteinprovided by RGD
    Primary source
    RGD:708410
    See related
    EnsemblRapid:ENSRNOG00000018220 AllianceGenome:RGD:708410
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables enzyme binding activity. Involved in protein-containing complex assembly. Located in centrosome and myofibril. Orthologous to human PDE4DIP (phosphodiesterase 4D interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 3186.8), Heart (RPKM 1355.8) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Pde4dip in Genome Data Viewer
    Location:
    2q34
    Exon count:
    53
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (187982002..188178937, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (185293236..185490100, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (199867965..200066034, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene protein kinase AMP-activated non-catalytic subunit beta 2 Neighboring gene uncharacterized LOC102550575 Neighboring gene transfer RNA glutamine (anticodon CUG) 4 Neighboring gene uncharacterized LOC134485662 Neighboring gene SEC22 homolog B, vesicle trafficking protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular Pathway of Microtubule Organization at the Golgi Apparatus. Wu J, et al. Dev Cell, 2016 Oct 10. PMID 27666745
    2. Myomegalin is a novel protein of the golgi/centrosome that interacts with a cyclic nucleotide phosphodiesterase. Verde I, et al. J Biol Chem, 2001 Apr 6. PMID 11134006
    3. Isolation of novel heart-specific genes using the BodyMap database. Soejima H, et al. Genomics, 2001 May 15. PMID 11374908
    4. Myomegalin is a novel A-kinase anchoring protein involved in the phosphorylation of cardiac myosin binding protein C. Uys GM, et al. BMC Cell Biol, 2011 May 10. PMID 21569246, Free PMC Article
    5. EB1-binding-myomegalin protein complex promotes centrosomal microtubules functions. Bouguenina H, et al. Proc Natl Acad Sci U S A, 2017 Dec 12. PMID 29162697, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MMGL isoform 4 is involved in the phosphorylation of Cardiac Myosin Binding Protein-C as well as cardiac troponin I.
      Title: Myomegalin is a novel A-kinase anchoring protein involved in the phosphorylation of cardiac myosin binding protein C.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in astral microtubule organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in centrosome cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of microtubule nucleation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein-containing complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of Golgi organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cortical microtubule plus-end ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule organizing center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in myofibril IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    myomegalin
    Names
    phosphodiesterase-binding protein clone 46

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001389233.1 → NP_001376162.1  myomegalin isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6K3C0
      Related
      ENSRNOP00000103442.1, ENSRNOT00000147765.1
      Conserved Domains (4) summary
      TIGR02168
      Location:434 → 1160
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:128 → 592
      CCDC158; Coiled-coil domain-containing protein 158
      pfam06758
      Location:1677 → 1743
      DUF1220; Repeat of unknown function (DUF1220)
      pfam07989
      Location:126 → 193
      Cnn_1N; Centrosomin N-terminal motif 1

    2. NM_001389234.1 → NP_001376163.1  myomegalin isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6K3C0, A6K3C1
      Related
      ENSRNOP00000099519.1, ENSRNOT00000167159.1
      Conserved Domains (4) summary
      TIGR02168
      Location:434 → 1160
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:128 → 592
      CCDC158; Coiled-coil domain-containing protein 158
      pfam06758
      Location:1677 → 1743
      DUF1220; Repeat of unknown function (DUF1220)
      pfam07989
      Location:126 → 193
      Cnn_1N; Centrosomin N-terminal motif 1

    3. NM_001389235.1 → NP_001376164.1  myomegalin isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6K3C0
      Conserved Domains (4) summary
      TIGR02168
      Location:434 → 1160
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:128 → 592
      CCDC158; Coiled-coil domain-containing protein 158
      pfam06758
      Location:1677 → 1743
      DUF1220; Repeat of unknown function (DUF1220)
      pfam07989
      Location:126 → 193
      Cnn_1N; Centrosomin N-terminal motif 1

    4. NM_022382.2 → NP_071777.2  myomegalin isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6K3C2, F1M7R5
      Related
      ENSRNOP00000024900.6, ENSRNOT00000024900.8
      Conserved Domains (4) summary
      TIGR02168
      Location:314 → 1040
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:8 → 461
      CCDC158; Coiled-coil domain-containing protein 158
      pfam06758
      Location:1557 → 1623
      DUF1220; Repeat of unknown function (DUF1220)
      pfam07989
      Location:6 → 73
      Cnn_1N; Centrosomin N-terminal motif 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      187982002..188178937 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063282460.1 → XP_063138530.1  myomegalin isoform X21

      UniProtKB/TrEMBL
      A6K3C0
      Related
      ENSRNOP00000078787.2, ENSRNOT00000100009.2

    2. XM_017591079.3 → XP_017446568.1  myomegalin isoform X14

      UniProtKB/TrEMBL
      A6K3C0

    3. XM_017591075.3 → XP_017446564.1  myomegalin isoform X6

      UniProtKB/TrEMBL
      A6K3C0

    4. XM_063282458.1 → XP_063138528.1  myomegalin isoform X19

      UniProtKB/TrEMBL
      A6K3C0

    5. XM_017591078.3 → XP_017446567.1  myomegalin isoform X11

      UniProtKB/TrEMBL
      A6K3C0

    6. XM_063282453.1 → XP_063138523.1  myomegalin isoform X8

      UniProtKB/TrEMBL
      A6K3C0

    7. XM_063282454.1 → XP_063138524.1  myomegalin isoform X9

      UniProtKB/TrEMBL
      A6K3C0

    8. XM_017591072.3 → XP_017446561.1  myomegalin isoform X2

      UniProtKB/TrEMBL
      A6K3C0

    9. XM_063282457.1 → XP_063138527.1  myomegalin isoform X18

      UniProtKB/TrEMBL
      A6K3C0
      Related
      ENSRNOP00000100013.1, ENSRNOT00000167057.1

    10. XM_039103040.2 → XP_038958968.1  myomegalin isoform X10

      UniProtKB/TrEMBL
      A6K3C0
      Conserved Domains (4) summary
      TIGR02168
      Location:508 → 1234
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:202 → 666
      CCDC158; Coiled-coil domain-containing protein 158
      pfam06758
      Location:1751 → 1817
      DUF1220; Repeat of unknown function (DUF1220)
      pfam07989
      Location:200 → 267
      Cnn_1N; Centrosomin N-terminal motif 1

    11. XM_063282452.1 → XP_063138522.1  myomegalin isoform X7

      UniProtKB/TrEMBL
      A6K3C0

    12. XM_063282451.1 → XP_063138521.1  myomegalin isoform X3

      UniProtKB/TrEMBL
      A6K3C0

    13. XM_017591071.3 → XP_017446560.1  myomegalin isoform X1

      UniProtKB/TrEMBL
      A6K3C0

    14. XM_039103042.2 → XP_038958970.1  myomegalin isoform X13

      UniProtKB/TrEMBL
      A6K3C0
      Conserved Domains (4) summary
      TIGR02168
      Location:508 → 1234
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:202 → 666
      CCDC158; Coiled-coil domain-containing protein 158
      pfam06758
      Location:1751 → 1817
      DUF1220; Repeat of unknown function (DUF1220)
      pfam07989
      Location:200 → 267
      Cnn_1N; Centrosomin N-terminal motif 1

    15. XM_017591080.3 → XP_017446569.1  myomegalin isoform X15

      UniProtKB/TrEMBL
      A6K3C0

    16. XM_017591074.3 → XP_017446563.1  myomegalin isoform X5

      UniProtKB/TrEMBL
      A6K3C0

    17. XM_063282462.1 → XP_063138532.1  myomegalin isoform X23

      UniProtKB/TrEMBL
      A0A0G2JW66

    18. XM_017591081.3 → XP_017446570.1  myomegalin isoform X16

      UniProtKB/TrEMBL
      A0A0G2JW66
      Related
      ENSRNOP00000069762.3, ENSRNOT00000088041.3

    19. XM_039103044.2 → XP_038958972.1  myomegalin isoform X24

      UniProtKB/TrEMBL
      F1M7R5
      Conserved Domains (3) summary
      TIGR00618
      Location:21 → 533
      sbcc; exonuclease SbcC
      TIGR02168
      Location:305 → 1031
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam06758
      Location:1548 → 1614
      DUF1220; Repeat of unknown function (DUF1220)

    20. XM_063282463.1 → XP_063138533.1  myomegalin isoform X25

      UniProtKB/TrEMBL
      F1M7R5

    21. XM_039103045.2 → XP_038958973.1  myomegalin isoform X24

      UniProtKB/TrEMBL
      F1M7R5
      Conserved Domains (3) summary
      TIGR00618
      Location:21 → 533
      sbcc; exonuclease SbcC
      TIGR02168
      Location:305 → 1031
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam06758
      Location:1548 → 1614
      DUF1220; Repeat of unknown function (DUF1220)

    22. XM_039103043.2 → XP_038958971.1  myomegalin isoform X22

      UniProtKB/TrEMBL
      F1M7R5
      Conserved Domains (3) summary
      TIGR00618
      Location:41 → 553
      sbcc; exonuclease SbcC
      TIGR02168
      Location:325 → 1051
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam06758
      Location:1568 → 1634
      DUF1220; Repeat of unknown function (DUF1220)

    23. XM_063282471.1 → XP_063138541.1  myomegalin isoform X34

      UniProtKB/TrEMBL
      A0A8I6G2C1, A6K3C4

    24. XM_063282459.1 → XP_063138529.1  myomegalin isoform X20

      UniProtKB/TrEMBL
      A0A8I6APT7, A6K3C4

    25. XM_063282456.1 → XP_063138526.1  myomegalin isoform X17

      UniProtKB/TrEMBL
      A6K3C4

    26. XM_063282470.1 → XP_063138540.1  myomegalin isoform X33

      UniProtKB/TrEMBL
      A6K3C4

    27. XM_039103041.2 → XP_038958969.1  myomegalin isoform X12

      UniProtKB/TrEMBL
      A6K3C4
      Related
      ENSRNOP00000095141.2, ENSRNOT00000118806.2
      Conserved Domains (4) summary
      COG1196
      Location:2005 → 2236
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:476 → 1275
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam06758
      Location:1719 → 1785
      DUF1220; Repeat of unknown function (DUF1220)
      pfam18615
      Location:1 → 375
      SMYLE_N; Short myomegalin-like EB1 binding proteins, N-terminal domain

    28. XM_017591073.3 → XP_017446562.1  myomegalin isoform X4

      UniProtKB/TrEMBL
      A6K3C4

    29. XM_063282465.1 → XP_063138535.1  myomegalin isoform X28

    30. XM_039103046.2 → XP_038958974.1  myomegalin isoform X26

      Conserved Domains (3) summary
      PRK02224
      Location:668 → 1137
      PRK02224; DNA double-strand break repair Rad50 ATPase
      TIGR02168
      Location:203 → 844
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam07989
      Location:200 → 267
      Cnn_1N; Centrosomin N-terminal motif 1

    31. XM_063282467.1 → XP_063138537.1  myomegalin isoform X31

    32. XM_063282466.1 → XP_063138536.1  myomegalin isoform X30

    33. XM_063282469.1 → XP_063138539.1  myomegalin isoform X32

    34. XM_063282464.1 → XP_063138534.1  myomegalin isoform X27

    35. XM_039103047.2 → XP_038958975.2  myomegalin isoform X29

    RNA

    1. XR_001836491.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WUJ3.1 GenPept UniProtKB/Swiss-Prot:Q9WUJ3

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