Gpha2 glycoprotein hormone subunit alpha 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gpha2provided by RGD
Official Full Name: glycoprotein hormone subunit alpha 2provided by RGD
Primary source: RGD:621748
See related: EnsemblRapid:ENSRNOG00000021020 AllianceGenome:RGD:621748
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gpa2; Zsig51
Summary: Predicted to enable protein heterodimerization activity and thyrotropin-releasing hormone receptor binding activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and cell surface receptor signaling pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human GPHA2 (glycoprotein hormone subunit alpha 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 8.7), Thymus (RPKM 7.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (212954579..212956536)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (203525952..203527271)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (221594110..221597297)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that the presence of thyrostimulin in the ovary suggests that it may have a primitive function in reproduction when it activates ovarian TSHR.
Title: Thyrostimulin, but not thyroid-stimulating hormone (TSH), acts as a paracrine regulator to activate the TSH receptor in mammalian ovary.
Results describe the differential expression of the thyrostimulin subunits, glycoprotein alpha2 and beta5 in the rat pituitary, and suggest that the thyrostimulin system is functionally different from the thyroid-stimulating hormone system.
Title: Differential expression of the thyrostimulin subunits, glycoprotein alpha2 and beta5 in the rat pituitary.
Thyrostimulin immunoreactivity was visualized in the anterior pituitary, central nervous system, adrenal gland, stomach, duodenum, pancreas and testis; findings suggest that thyrostimulin is widely distributed [thyrostimulin]
Title: Distribution of thyrostimulin in the rat: an immunohistochemical study.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables thyrotropin-releasing hormone receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables thyrotropin-releasing hormone receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: glycoprotein hormone alpha-2

Names: cysteine knot protein; glycoprotein hormone alpha 2; glycoprotein-alpha 2; putative secreted protein ZSIG51; thyrostimulin subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133619.2 → NP_598303.1 glycoprotein hormone alpha-2 precursor

See identical proteins and their annotated locations for NP_598303.1

Status: PROVISIONAL

Source sequence(s)

AF260741

UniProtKB/Swiss-Prot

Q925Q4

UniProtKB/TrEMBL

A0A0F7RPV4

Related

ENSRNOP00000028536.2, ENSRNOT00000028536.5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

212954579..212956536

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063275625.1 → XP_063131695.1 glycoprotein hormone alpha-2 isoform X1

UniProtKB/Swiss-Prot

Q925Q4

UniProtKB/TrEMBL

A0A0F7RPV4
XM_063275585.1 → XP_063131655.1 glycoprotein hormone alpha-2 isoform X1

UniProtKB/Swiss-Prot

Q925Q4

UniProtKB/TrEMBL

A0A0F7RPV4
XM_063275540.1 → XP_063131610.1 glycoprotein hormone alpha-2 isoform X1

UniProtKB/Swiss-Prot

Q925Q4

UniProtKB/TrEMBL

A0A0F7RPV4