Tlr7 toll-like receptor 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tlr7provided by RGD
Official Full Name: toll-like receptor 7provided by RGD
Primary source: RGD:1563357
See related: EnsemblRapid:ENSRNOG00000004249 AllianceGenome:RGD:1563357
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1563357
Summary: Predicted to enable RNA binding activity and pattern recognition receptor activity. Predicted to be involved in several processes, including intracellular signal transduction; positive regulation of macromolecule biosynthetic process; and response to virus. Predicted to act upstream of or within positive regulation of macrophage cytokine production and regulation of protein phosphorylation. Predicted to be located in cytoplasmic vesicle; endoplasmic reticulum; and lysosome. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Biomarker of perinatal necrotizing enterocolitis. Human ortholog(s) of this gene implicated in COVID-19 and X-Linked immunodeficiency 74. Orthologous to human TLR7 (toll like receptor 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 205.2), Thymus (RPKM 42.9) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq13

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (30644324..30670796)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (27027380..27054309)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (28486836..28513004)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TLR7 activation by miR-21 promotes renal fibrosis by activating the pro-inflammatory signaling pathway in tubule epithelial cells.
Title: TLR7 activation by miR-21 promotes renal fibrosis by activating the pro-inflammatory signaling pathway in tubule epithelial cells.
The Local Activation of Toll-like Receptor 7 (TLR7) Modulates Colonic Epithelial Barrier Function in Rats.
Title: The Local Activation of Toll-like Receptor 7 (TLR7) Modulates Colonic Epithelial Barrier Function in Rats.
Astrocyte-derived exosome-transported microRNA-34c is neuroprotective against cerebral ischemia/reperfusion injury via TLR7 and the NF-kappaB/MAPK pathways.
Title: Astrocyte-derived exosome-transported microRNA-34c is neuroprotective against cerebral ischemia/reperfusion injury via TLR7 and the NF-κB/MAPK pathways.
fluoxetine treatment reversed depressive-like behaviour and molecularly modulated the expression of TLR7, suggesting that fluoxetine exerts antidepressant effects partially by modulating the TLR7 signaling pathway.
Title: Assessing the role of toll-like receptor in isolated, standard and enriched housing conditions.
Small RNAs induce the activation of the pro-inflammatory TLR7 signaling pathway in aged rat kidney.
Title: Small RNAs induce the activation of the pro-inflammatory TLR7 signaling pathway in aged rat kidney.
This is the first quantitative description of toll-like receptors 4 and 7 expression within adult mammalian sensory ganglia in relation to functional neuronal phenotype.
Title: The expression of Toll-like receptor 4, 7 and co-receptors in neurochemical sub-populations of rat trigeminal ganglion sensory neurons.
Cardiac RNA induces inflammatory responses in cardiomyocytes and immune cells via MyD88-TLR7 signaling.
Title: Cardiac RNA induces inflammatory responses in cardiomyocytes and immune cells via Toll-like receptor 7 signaling.
evaluated (1) the incidence of ONFH in rats after the administration of TLR7 or TLR9 ligands together with methylprednisolone (MPSL) and (2) whether transcription factors contribute to the development of ONFH
Title: Development of non-traumatic osteonecrosis of the femoral head requires toll-like receptor 7 and 9 stimulations and is boosted by repression on nuclear factor kappa B in rats.
aortic angiogenesis is preceded by an immune reaction with overexpression of Toll-like receptors (TLRs) and TLR-inducible genes.
Title: Regulation of angiogenesis, mural cell recruitment and adventitial macrophage behavior by Toll-like receptors.
obstructive jaundice is associated with down-regulation of TLR7 and up-regulation of profibrogenic gene expression in hepatic stellate cells
Title: Selective activation of Toll-like receptor 7 in activated hepatic stellate cells may modulate their profibrogenic phenotype.

Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables double-stranded RNA binding	ISO Inferred from Sequence Orthology more info
enables pattern recognition receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables siRNA binding	ISO Inferred from Sequence Orthology more info
enables single-stranded RNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in I-kappaB phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in cellular response to mechanical stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to virus	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interferon-alpha production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interferon-beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of macrophage cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in response to cGMP	ISO Inferred from Sequence Orthology more info
involved_in toll-like receptor 7 signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in toll-like receptor 7 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in toll-like receptor 8 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in toll-like receptor 8 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in toll-like receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in early phagosome	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: toll-like receptor 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001097582.1 → NP_001091051.1 toll-like receptor 7

See identical proteins and their annotated locations for NP_001091051.1

Status: PROVISIONAL

Source sequence(s)

EF032637

UniProtKB/TrEMBL

A5H2Z9, U5LJA3

Related

ENSRNOP00000094649.2, ENSRNOT00000118923.2

Conserved Domains (4) summary

smart00255
Location:891 → 1036

TIR; Toll - interleukin 1 - resistance

PLN00113
Location:190 → 734

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:497 → 519

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:75 → 139

LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

30644324..30670796

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017602079.3 → XP_017457568.1 toll-like receptor 7 isoform X1

UniProtKB/TrEMBL

A0A8I6AM21, U5LJA3

Related

ENSRNOP00000089883.2, ENSRNOT00000104011.2

Conserved Domains (4) summary

smart00255
Location:909 → 1054

TIR; Toll - interleukin 1 - resistance

cd00116
Location:532 → 778

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:515 → 537

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:308 → 368

LRR_8; Leucine rich repeat
XM_039099834.2 → XP_038955762.1 toll-like receptor 7 isoform X3

UniProtKB/TrEMBL

A0A8I6GHR4, A6K2G1, U5LJA3

Related

ENSRNOP00000005620.5, ENSRNOT00000005620.8

Conserved Domains (5) summary

TIGR00864
Location:750 → 834

PCC; polycystin cation channel protein

smart00255
Location:887 → 1032

TIR; Toll - interleukin 1 - resistance

PLN00113
Location:186 → 730

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:493 → 515

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:71 → 135

LRR_8; Leucine rich repeat
XM_017602080.3 → XP_017457569.1 toll-like receptor 7 isoform X1

UniProtKB/TrEMBL

A0A8I6AM21, U5LJA3

Conserved Domains (4) summary

smart00255
Location:909 → 1054

TIR; Toll - interleukin 1 - resistance

cd00116
Location:532 → 778

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:515 → 537

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:308 → 368

LRR_8; Leucine rich repeat
XM_063280082.1 → XP_063136152.1 toll-like receptor 7 isoform X3

UniProtKB/TrEMBL

A0A8I6GHR4, A6K2G1, U5LJA3
XM_039099833.2 → XP_038955761.1 toll-like receptor 7 isoform X2

UniProtKB/TrEMBL

A5H2Z9, U5LJA3

Conserved Domains (4) summary

smart00255
Location:891 → 1036

TIR; Toll - interleukin 1 - resistance

PLN00113
Location:190 → 734

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:497 → 519

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:75 → 139

LRR_8; Leucine rich repeat