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    Ica1l islet cell autoantigen 1-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316432, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ica1lprovided by RGD
    Official Full Name
    islet cell autoantigen 1-likeprovided by RGD
    Primary source
    RGD:735110
    See related
    EnsemblRapid:ENSRNOG00000017258 AllianceGenome:RGD:735110
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein domain specific binding activity. Predicted to be involved in regulation of transport. Predicted to act upstream of or within spermatid development. Predicted to be located in acrosomal vesicle. Predicted to be active in Golgi apparatus. Orthologous to human ICA1L (islet cell autoantigen 1 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 88.7), Brain (RPKM 63.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ica1l in Genome Data Viewer
    Location:
    9q31-q32
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (68906148..68964078, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (61410959..61469884, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (66788094..66848958, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene diazepam binding inhibitor, acyl-CoA binding protein, pseudogene 3 Neighboring gene family with sequence similarity 117, member B Neighboring gene uncharacterized LOC120094801 Neighboring gene WD repeat domain 12 Neighboring gene calcium responsive transcription factor Neighboring gene basic proline-rich protein-like Neighboring gene neurobeachin-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ICA1L forms BAR-domain complexes with PICK1 and is crucial for acrosome formation in spermiogenesis. He J, et al. J Cell Sci, 2015 Oct 15. PMID 26306493
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ICA1L forms BAR-domain complexes with PICK1 and is crucial for acrosome formation in spermiogenesis.
      Title: ICA1L forms BAR-domain complexes with PICK1 and is crucial for acrosome formation in spermiogenesis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within spermatid development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    islet cell autoantigen 1-like protein
    Names
    Ica69-related protein
    amyotrophic lateral sclerosis 2 chromosomal region candidate gene 15 protein homolog
    islet cell autoantigen 1, 69kDa-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199400.2 → NP_955432.1  islet cell autoantigen 1-like protein

      See identical proteins and their annotated locations for NP_955432.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      Q6RUG5
      UniProtKB/TrEMBL
      A0A0H2UHX6
      Related
      ENSRNOP00000045103.4, ENSRNOT00000041546.4
      Conserved Domains (2) summary
      pfam04629
      Location:254 → 435
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      cl12013
      Location:46 → 248
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      68906148..68964078 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017596464.3 → XP_017451953.1  islet cell autoantigen 1-like protein isoform X7

      UniProtKB/TrEMBL
      A0A0H2UHX6
      Conserved Domains (2) summary
      pfam04629
      Location:255 → 468
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      cl12013
      Location:46 → 248
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    2. XM_063267208.1 → XP_063123278.1  islet cell autoantigen 1-like protein isoform X14

      UniProtKB/TrEMBL
      A0A0H2UHX6

    3. XM_063267204.1 → XP_063123274.1  islet cell autoantigen 1-like protein isoform X9

      UniProtKB/TrEMBL
      A0A0H2UHX6

    4. XM_063267211.1 → XP_063123281.1  islet cell autoantigen 1-like protein isoform X18

      UniProtKB/TrEMBL
      A0A0H2UHX6

    5. XM_063267207.1 → XP_063123277.1  islet cell autoantigen 1-like protein isoform X12

      UniProtKB/TrEMBL
      A0A0H2UHX6

    6. XM_063267212.1 → XP_063123282.1  islet cell autoantigen 1-like protein isoform X19

      UniProtKB/TrEMBL
      A0A0H2UHX6

    7. XM_063267210.1 → XP_063123280.1  islet cell autoantigen 1-like protein isoform X17

      UniProtKB/TrEMBL
      A0A0H2UHX6, A0A8I5XZZ8, A6IPB8

    8. XM_063267209.1 → XP_063123279.1  islet cell autoantigen 1-like protein isoform X15

      UniProtKB/Swiss-Prot
      Q6RUG5
      UniProtKB/TrEMBL
      A0A0H2UHX6

    9. XM_039083635.2 → XP_038939563.1  islet cell autoantigen 1-like protein isoform X7

      UniProtKB/TrEMBL
      A0A0H2UHX6
      Conserved Domains (2) summary
      pfam04629
      Location:255 → 468
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      cl12013
      Location:46 → 248
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    10. XM_063267206.1 → XP_063123276.1  islet cell autoantigen 1-like protein isoform X11

      UniProtKB/TrEMBL
      A0A0H2UHX6
      Related
      ENSRNOP00000094417.2, ENSRNOT00000094628.2

    11. XM_008767111.3 → XP_008765333.1  islet cell autoantigen 1-like protein isoform X3

      UniProtKB/TrEMBL
      A0A0H2UHX6
      Conserved Domains (2) summary
      pfam04629
      Location:270 → 484
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      cl12013
      Location:68 → 264
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    12. XM_039083634.2 → XP_038939562.1  islet cell autoantigen 1-like protein isoform X2

      UniProtKB/TrEMBL
      A0A0H2UHX6
      Conserved Domains (2) summary
      pfam04629
      Location:277 → 489
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      cl12013
      Location:68 → 270
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    13. XM_063267203.1 → XP_063123273.1  islet cell autoantigen 1-like protein isoform X8

      UniProtKB/TrEMBL
      A0A0H2UHX6

    14. XM_063267205.1 → XP_063123275.1  islet cell autoantigen 1-like protein isoform X10

      UniProtKB/TrEMBL
      A0A0H2UHX6

    15. XM_063267202.1 → XP_063123272.1  islet cell autoantigen 1-like protein isoform X5

      UniProtKB/TrEMBL
      A0A0H2UHX6

    16. XM_039083637.2 → XP_038939565.1  islet cell autoantigen 1-like protein isoform X20

      Conserved Domains (2) summary
      pfam04629
      Location:326 → 364
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      cl12013
      Location:68 → 270
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    17. XM_039083636.2 → XP_038939564.1  islet cell autoantigen 1-like protein isoform X16

      UniProtKB/TrEMBL
      A0A0H2UHX6
      Conserved Domains (2) summary
      pfam04629
      Location:277 → 432
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      cl12013
      Location:68 → 270
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    18. XM_006244999.4 → XP_006245061.1  islet cell autoantigen 1-like protein isoform X13

      UniProtKB/TrEMBL
      A0A0H2UHX6
      Related
      ENSRNOP00000076459.2, ENSRNOT00000119954.2
      Conserved Domains (2) summary
      pfam04629
      Location:276 → 449
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      cl12013
      Location:68 → 270
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    19. XM_017596461.3 → XP_017451950.1  islet cell autoantigen 1-like protein isoform X6

      UniProtKB/TrEMBL
      A0A0H2UHX6

    20. XM_006244994.4 → XP_006245056.1  islet cell autoantigen 1-like protein isoform X1

      UniProtKB/TrEMBL
      A0A0H2UHX6
      Related
      ENSRNOP00000104337.1, ENSRNOT00000135120.1
      Conserved Domains (2) summary
      pfam04629
      Location:277 → 490
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      cl12013
      Location:68 → 270
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    21. XM_006244995.4 → XP_006245057.1  islet cell autoantigen 1-like protein isoform X4

      UniProtKB/TrEMBL
      A0A0H2UHX6, A0A8I6AM57
      Conserved Domains (2) summary
      pfam04629
      Location:276 → 474
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      cl12013
      Location:68 → 270
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    22. XM_039083638.2 → XP_038939566.1  islet cell autoantigen 1-like protein isoform X21

      Conserved Domains (2) summary
      pfam04629
      Location:104 → 317
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      cl12013
      Location:1 → 97
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6RUG5.1 GenPept UniProtKB/Swiss-Prot:Q6RUG5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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