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    Uvrag UV radiation resistance associated [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308846, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Uvragprovided by RGD
    Official Full Name
    UV radiation resistance associatedprovided by RGD
    Primary source
    RGD:1589754
    See related
    EnsemblRapid:ENSRNOG00000016206 AllianceGenome:RGD:1589754
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable SH3 domain binding activity and SNARE binding activity. Predicted to be involved in several processes, including SNARE complex assembly; double-strand break repair via classical nonhomologous end joining; and microtubule cytoskeleton organization. Predicted to act upstream of or within symbiont entry into host cell. Predicted to be located in several cellular components, including cytoplasmic vesicle; midbody; and vacuole. Predicted to be part of DNA-dependent protein kinase complex and phosphatidylinositol 3-kinase complex, class III. Predicted to be active in endosome and lytic vacuole. Orthologous to human UVRAG (UV radiation resistance associated). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 105.5), Lung (RPKM 92.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Uvrag in Genome Data Viewer
    Location:
    1q32
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (162596514..162854348, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (153185356..153442200, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (163844804..164101568, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485157 Neighboring gene Wnt family member 11 Neighboring gene ribosomal protein L27 like 2 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC120099889 Neighboring gene uncharacterized LOC120099888 Neighboring gene diacylglycerol O-acyltransferase 2 Neighboring gene uncharacterized LOC134483760 Neighboring gene monoacylglycerol O-acyltransferase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A dual role for UVRAG in maintaining chromosomal stability independent of autophagy. Zhao Z, et al. Dev Cell, 2012 May 15. PMID 22542840, Free PMC Article
    2. Pacer Mediates the Function of Class III PI3K and HOPS Complexes in Autophagosome Maturation by Engaging Stx17. Cheng X, et al. Mol Cell, 2017 Mar 16. PMID 28306502
    3. Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis. Takahashi Y, et al. Nat Cell Biol, 2007 Oct. PMID 17891140, Free PMC Article
    4. Interaction of microtubule-associated protein-2 and p63: a new link between microtubules and rough endoplasmic reticulum membranes in neurons. Farah CA, et al. J Biol Chem, 2005 Mar 11. PMID 15623521
    5. PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex. He S, et al. Nat Cell Biol, 2013 Oct. PMID 24056303, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In cultured hippocampal neurons, MAP2 and p63 were found to concomitantly compartmentalize to the dendritic processes during neuronal differentiation.
      Title: Interaction of microtubule-associated protein-2 and p63: a new link between microtubules and rough endoplasmic reticulum membranes in neurons.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNARE binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in SNARE complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within SNARE complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in autophagosome maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in centrosome cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in double-strand break repair via classical nonhomologous end joining ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in maintenance of Golgi location ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylinositol-3-phosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in receptor catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spindle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within symbiont entry into host cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of DNA-dependent protein kinase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in autophagosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lytic vacuole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in phagocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of phosphatidylinositol 3-kinase complex, class III ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    UV radiation resistance-associated gene protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107536.1 → NP_001101006.1  UV radiation resistance-associated gene protein isoform 2

      See identical proteins and their annotated locations for NP_001101006.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473956
      UniProtKB/TrEMBL
      A6I6F5
      Conserved Domains (2) summary
      cd00030
      Location:44 → 118
      C2; C2 domain
      pfam10186
      Location:215 → 394
      Atg14; Vacuolar sorting 38 and autophagy-related subunit 14

    2. NM_001401542.1 → NP_001388471.1  UV radiation resistance-associated gene protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6I6F4, D3ZKE1
      Related
      ENSRNOP00000022176.6, ENSRNOT00000022176.9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      162596514..162854348 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039113251.2 → XP_038969179.1  UV radiation resistance-associated gene protein isoform X2

      Conserved Domains (1) summary
      pfam10186
      Location:50 → 173
      Atg14; Vacuolar sorting 38 and autophagy-related subunit 14

    2. XM_039113238.2 → XP_038969166.1  UV radiation resistance-associated gene protein isoform X1

      Conserved Domains (2) summary
      cd00030
      Location:44 → 118
      C2; C2 domain
      pfam10186
      Location:183 → 441
      Atg14; Vacuolar sorting 38 and autophagy-related subunit 14

    3. XM_039113255.2 → XP_038969183.1  UV radiation resistance-associated gene protein isoform X3

      UniProtKB/TrEMBL
      A6I6F6
      Conserved Domains (2) summary
      pfam10186
      Location:183 → 394
      Atg14; Vacuolar sorting 38 and autophagy-related subunit 14
      pfam17649
      Location:39 → 262
      VPS38; Vacuolar protein sorting 38
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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