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    Aifm2 AIF family member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361843, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Aifm2provided by RGD
    Official Full Name
    AIF family member 2provided by RGD
    Primary source
    RGD:1304964
    See related
    EnsemblRapid:ENSRNOG00000059445 AllianceGenome:RGD:1304964
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Amid; Prg3
    Summary
    Predicted to enable several functions, including electron-transferring-flavoprotein dehydrogenase activity; flavin adenine dinucleotide binding activity; and oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor. Predicted to be involved in several processes, including negative regulation of ferroptosis; regulation of cellular response to oxidative stress; and vitamin K metabolic process. Predicted to be located in several cellular components, including cytosol; lipid droplet; and mitochondrial outer membrane. Predicted to be active in mitochondrion. Orthologous to human AIFM2 (AIF family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 498.9), Thymus (RPKM 127.3) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Aifm2 in Genome Data Viewer
    Location:
    20q11
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (30195781..30222014)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (29654283..29679239)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (31329047..31353548)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene secretion associated, Ras related GTPase 1A Neighboring gene trypsin like peroxisomal matrix peptidase 1 Neighboring gene macroH2A.2 histone Neighboring gene proline-rich protein HaeIII subfamily 1-like Neighboring gene transfer RNA alanine (anticodon AGC) 46

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. Bersuker K, et al. Nature, 2019 Nov. PMID 31634900, Free PMC Article
    2. FSP1 is a glutathione-independent ferroptosis suppressor. Doll S, et al. Nature, 2019 Nov. PMID 31634899
    3. The p53-inducible apoptotic protein AMID is not required for normal development and tumor suppression. Mei J, et al. Oncogene, 2006 Feb 9. PMID 16186796
    4. The human apoptosis-inducing protein AMID is an oxidoreductase with a modified flavin cofactor and DNA binding activity. Marshall KR, et al. J Biol Chem, 2005 Sep 2. PMID 15958387
    5. A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF). Ohiro Y, et al. FEBS Lett, 2002 Jul 31. PMID 12135761

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Functional characterization of the mouse Amid ortholog and comparison to the human protein.
      Title: The p53-inducible apoptotic protein AMID is not required for normal development and tumor suppression.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables electron-transferring-flavoprotein dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables electron-transferring-flavoprotein dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin adenine dinucleotide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic mitochondrial changes IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within apoptotic mitochondrial changes ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular detoxification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of ferroptosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in respiratory electron transport chain IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquinone metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vitamin K metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ferroptosis suppressor protein 1
    Names
    apoptosis inducing factor, mitochondria associated 2
    apoptosis-inducing factor (AIF)-like mitochondrion-associated inducer of death
    apoptosis-inducing factor 2
    apoptosis-inducing factor, mitochondrion-associated 2
    NP_001132955.1
    XP_006256515.1
    XP_006256516.1
    XP_006256518.1
    XP_008771110.1
    XP_017457180.1
    XP_038954799.1
    XP_038954801.1
    XP_063135364.1
    XP_063135365.1
    XP_063135366.1
    XP_063135367.1
    XP_063135369.1
    XP_063135370.1
    XP_063135371.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001139483.1 → NP_001132955.1  ferroptosis suppressor protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      D4AA14
      Related
      ENSRNOP00000076399.2, ENSRNOT00000118141.2
      Conserved Domains (1) summary
      pfam07992
      Location:20 → 302
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      30195781..30222014
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279294.1 → XP_063135364.1  ferroptosis suppressor protein 1 isoform X5

      UniProtKB/TrEMBL
      D4AA14

    2. XM_006256456.5 → XP_006256518.1  ferroptosis suppressor protein 1 isoform X5

      See identical proteins and their annotated locations for XP_006256518.1

      UniProtKB/TrEMBL
      D4AA14
      Conserved Domains (1) summary
      cl39093
      Location:39 → 357
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    3. XM_063279296.1 → XP_063135366.1  ferroptosis suppressor protein 1 isoform X6

      UniProtKB/TrEMBL
      D4AA14

    4. XM_008772888.3 → XP_008771110.1  ferroptosis suppressor protein 1 isoform X1

      See identical proteins and their annotated locations for XP_008771110.1

      UniProtKB/TrEMBL
      D4AA14
      Conserved Domains (1) summary
      pfam07992
      Location:50 → 333
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    5. XM_006256453.4 → XP_006256515.1  ferroptosis suppressor protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZQB7, D4AA14
      Related
      ENSRNOP00000071310.3, ENSRNOT00000082463.3
      Conserved Domains (1) summary
      cl39093
      Location:69 → 386
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    6. XM_017601691.3 → XP_017457180.1  ferroptosis suppressor protein 1 isoform X7

      UniProtKB/TrEMBL
      A0A8I5XUU7

    7. XM_063279297.1 → XP_063135367.1  ferroptosis suppressor protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A8I5XUU7

    8. XM_063279300.1 → XP_063135370.1  ferroptosis suppressor protein 1 isoform X10

      UniProtKB/TrEMBL
      A6K418

    9. XM_063279301.1 → XP_063135371.1  ferroptosis suppressor protein 1 isoform X11

      UniProtKB/TrEMBL
      A6K418

    10. XM_006256454.5 → XP_006256516.1  ferroptosis suppressor protein 1 isoform X3

      UniProtKB/TrEMBL
      D4AA14
      Conserved Domains (1) summary
      pfam07992
      Location:44 → 327
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    11. XM_063279299.1 → XP_063135369.1  ferroptosis suppressor protein 1 isoform X9

      UniProtKB/TrEMBL
      A0A8I5XUU7

    12. XM_039098871.2 → XP_038954799.1  ferroptosis suppressor protein 1 isoform X4

      UniProtKB/TrEMBL
      D4AA14
      Conserved Domains (1) summary
      cl39093
      Location:63 → 380
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    13. XM_039098873.2 → XP_038954801.1  ferroptosis suppressor protein 1 isoform X5

      UniProtKB/TrEMBL
      D4AA14
      Conserved Domains (1) summary
      cl39093
      Location:39 → 357
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    14. XM_063279295.1 → XP_063135365.1  ferroptosis suppressor protein 1 isoform X6

      UniProtKB/TrEMBL
      D4AA14

    RNA

    1. XR_005497285.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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