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    Sppl3 signal peptide peptidase like 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360822, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sppl3provided by RGD
    Official Full Name
    signal peptide peptidase like 3provided by RGD
    Primary source
    RGD:1562826
    See related
    EnsemblRapid:ENSRNOG00000001178 AllianceGenome:RGD:1562826
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sppl3-ps1; RGD1562826
    Summary
    Predicted to enable aspartic endopeptidase activity, intramembrane cleaving and protein homodimerization activity. Predicted to be involved in several processes, including T cell receptor signaling pathway; positive regulation of calcineurin-NFAT signaling cascade; and signal peptide processing. Predicted to be located in endoplasmic reticulum-Golgi intermediate compartment membrane; plasma membrane; and rough endoplasmic reticulum. Predicted to be active in Golgi-associated vesicle membrane; cytoplasmic side of endoplasmic reticulum membrane; and lumenal side of endoplasmic reticulum membrane. Orthologous to human SPPL3 (signal peptide peptidase like 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 128.9), Thymus (RPKM 102.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sppl3 in Genome Data Viewer
    Location:
    12q16
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (47176317..47260756, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (41515635..41600079, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (47276485..47360552, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene unc-119 lipid binding chaperone B Neighboring gene acyl-CoA dehydrogenase short chain Neighboring gene HNF1 homeobox A Neighboring gene similar to human chromosome 12 open reading frame 43 Neighboring gene uncharacterized LOC134481304 Neighboring gene 2'-5'-oligoadenylate synthetase-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A protease-independent function for SPPL3 in NFAT activation. Makowski SL, et al. Mol Cell Biol, 2015 Jan. PMID 25384971, Free PMC Article
    2. In vivo measurements of ethanol concentration in rabbit brain by 1H magnetic resonance spectroscopy. Petroff OA, et al. J Neurochem, 1990 Apr. PMID 2313285
    3. Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase. Nyborg AC, et al. FASEB J, 2006 Aug. PMID 16873890
    4. Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3. Krawitz P, et al. J Biol Chem, 2005 Nov 25. PMID 15998642
    5. SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production. Friedmann E, et al. Nat Cell Biol, 2006 Aug. PMID 16829952

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables aspartic endopeptidase activity, intramembrane cleaving IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aspartic endopeptidase activity, intramembrane cleaving ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in membrane protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in membrane protein proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in membrane protein proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of calcineurin-NFAT signaling cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal peptide processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi-associated vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi-associated vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasmic side of endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic side of endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lumenal side of endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lumenal side of endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in rough endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    signal peptide peptidase like 3; signal peptide peptidase-like 3
    Names
    signal peptide peptidase 3
    signal peptide peptidase-like 3, pseudogene 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431833.1 → NP_001418762.1  signal peptide peptidase like 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      D3ZY49

    2. NM_001431834.1 → NP_001418763.1  signal peptide peptidase like 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A6J1X2

    3. NM_001431835.1 → NP_001418764.1  signal peptide peptidase like 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      47176317..47260756 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003751200.5 → XP_003751248.1  signal peptide peptidase-like 3

      Related
      ENSRNOP00000103327.1, ENSRNOT00000163438.1
      Conserved Domains (1) summary
      pfam04258
      Location:60 → 374
      Peptidase_A22B; Signal peptide peptidase

    RNA

    1. XR_010056808.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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