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    Eng endoglin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 497010, updated on 9-Dec-2024

    Summary

    Symbol
    Engprovided by RGD
    Full Name
    endoglinprovided by RGD
    Primary source
    RGD:1593188
    See related
    EnsemblRapid:ENSRNOG00000050190 AllianceGenome:RGD:1593188
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables type II transforming growth factor beta receptor binding activity. Involved in several processes, including cellular response to mechanical stimulus; positive regulation of collagen biosynthetic process; and positive regulation of macromolecule metabolic process. Located in cell surface and extracellular space. Used to study congestive heart failure; pre-eclampsia; and renal fibrosis. Biomarker of cholestasis; congestive heart failure; hepatocellular carcinoma; hypertension (multiple); and renal fibrosis. Human ortholog(s) of this gene implicated in arteriovenous malformation; arteriovenous malformations of the brain; breast cancer; hereditary hemorrhagic telangiectasia; and intracranial aneurysm. Orthologous to human ENG (endoglin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 746.2), Heart (RPKM 349.5) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Eng in Genome Data Viewer
    Location:
    3p11
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (36332190..36370324)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (15934566..15972618)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (11679530..11717486)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 Neighboring gene adenylate kinase 1 Neighboring gene folylpolyglutamate synthase Neighboring gene cyclin-dependent kinase 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC124909

    Gene Ontology Provided by RGD

    Items 1 - 25 of 61
    Process Evidence Code Pubs
    acts_upstream_of_or_within angiogenesis  
    involved_in artery morphogenesis  
    involved_in atrial cardiac muscle tissue morphogenesis  
    involved_in atrioventricular canal morphogenesis  
    involved_in bone development PubMed 
    involved_in branching involved in blood vessel morphogenesis  
    involved_in cardiac atrium morphogenesis  
    NOT involved_in cardiac jelly development  
    involved_in cardiac ventricle morphogenesis  
    involved_in cell chemotaxis  
    involved_in cell migration  
    acts_upstream_of_or_within cell migration involved in endocardial cushion formation  
    involved_in cell motility  
    involved_in cellular response to mechanical stimulus PubMed 
    involved_in central nervous system vasculogenesis  
    involved_in detection of hypoxia  
    involved_in dorsal aorta morphogenesis  
    involved_in endocardial cushion morphogenesis  
    NOT involved_in endocardial cushion to mesenchymal transition  
    involved_in epithelial to mesenchymal transition involved in endocardial cushion formation  
    involved_in extracellular matrix constituent secretion PubMed 
    involved_in extracellular matrix disassembly  
    acts_upstream_of_or_within heart development  
    involved_in heart looping  
    involved_in negative regulation of SMAD protein signal transduction  
    involved_in negative regulation of cell migration  
    involved_in negative regulation of endothelial cell proliferation  
    involved_in negative regulation of gene expression  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in outflow tract septum morphogenesis  
    involved_in positive regulation of BMP signaling pathway  
    involved_in positive regulation of SMAD protein signal transduction  
    acts_upstream_of_or_within positive regulation of angiogenesis  
    involved_in positive regulation of collagen biosynthetic process PubMed 
    involved_in positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation  
    involved_in positive regulation of gene expression PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of protein phosphorylation PubMed 
    involved_in positive regulation of systemic arterial blood pressure  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of vascular associated smooth muscle cell differentiation  
    involved_in regulation of DNA-templated transcription  
    NOT involved_in regulation of cardiac muscle cell apoptotic process  
    NOT involved_in regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis  
    NOT involved_in regulation of cell proliferation involved in heart morphogenesis  
    involved_in regulation of transforming growth factor beta receptor signaling pathway PubMed 
    involved_in regulation of transforming growth factor beta receptor signaling pathway  
    involved_in response to hypoxia  
    involved_in response to transforming growth factor beta PubMed 
    involved_in response to xenobiotic stimulus PubMed 
    involved_in smooth muscle tissue development  
    NOT involved_in sprouting angiogenesis  
    NOT involved_in transforming growth factor beta receptor signaling pathway  
    involved_in transforming growth factor beta receptor signaling pathway  
    involved_in vascular associated smooth muscle cell development  
    involved_in vasculogenesis  
    acts_upstream_of_or_within vasculogenesis  
    involved_in vasculogenesis  
    involved_in venous blood vessel morphogenesis  
    involved_in ventricular trabecula myocardium morphogenesis  
    involved_in wound healing  
    Items 1 - 25 of 61
    Component Evidence Code Pubs
    is_active_in cell surface  
    located_in cell surface PubMed 
    located_in cell surface  
    located_in endothelial microparticle  
    located_in external side of plasma membrane  
    is_active_in extracellular space  
    located_in extracellular space PubMed 
    located_in extracellular space  
    located_in nuclear body  
    located_in nuclear body  
    located_in plasma membrane  
    part_of receptor complex  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001010968.3 → NP_001010968.1  endoglin precursor

      See identical proteins and their annotated locations for NP_001010968.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6GL08, A0A9K3Y7N3, M0RBA8, Q6Q3E8
      Related
      ENSRNOP00000066838.4, ENSRNOT00000074562.5
      Conserved Domains (1) summary
      smart00241
      Location:359 → 499
      ZP; Zona pellucida (ZP) domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      36332190..36370324
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284324.1 → XP_063140394.1  endoglin isoform X1

      UniProtKB/TrEMBL
      A0A8I6GL08, Q3KR75
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