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    Mlx MAX dimerization protein MLX [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360631, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mlxprovided by RGD
    Official Full Name
    MAX dimerization protein MLXprovided by RGD
    Primary source
    RGD:1308590
    See related
    EnsemblRapid:ENSRNOG00000019983 AllianceGenome:RGD:1308590
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tcfl4
    Summary
    Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein dimerization activity. Predicted to be involved in positive regulation of glycolytic process; positive regulation of lipid biosynthetic process; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within nucleocytoplasmic transport. Predicted to be located in cytosol; nuclear membrane; and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Takayasu's arteritis. Orthologous to human MLX (MAX dimerization protein MLX). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 190.7), Kidney (RPKM 187.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mlx in Genome Data Viewer
    Location:
    10q31
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (86519517..86524607)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (86019216..86024326)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (88997011..89002154)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene hydroxysteroid (17-beta) dehydrogenase 1 Neighboring gene Coenzyme A synthase Neighboring gene PSMC3 interacting protein Neighboring gene uncharacterized LOC134480875 Neighboring gene reticulophagy regulator family member 3 Neighboring gene tubulin, gamma 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Single-Nucleotide Polymorphism of the MLX Gene Is Associated With Takayasu Arteritis. Tamura N, et al. Circ Genom Precis Med, 2018 Oct. PMID 30354298, Free PMC Article
    2. Regulation of rat hepatic L-pyruvate kinase promoter composition and activity by glucose, n-3 polyunsaturated fatty acids, and peroxisome proliferator-activated receptor-alpha agonist. Xu J, et al. J Biol Chem, 2006 Jul 7. PMID 16644726, Free PMC Article
    3. Two susceptibility loci to Takayasu arteritis reveal a synergistic role of the IL12B and HLA-B regions in a Japanese population. Terao C, et al. Am J Hum Genet, 2013 Aug 8. PMID 23830516, Free PMC Article
    4. ChREBP*Mlx is the principal mediator of glucose-induced gene expression in the liver. Ma L, et al. J Biol Chem, 2006 Sep 29. PMID 16885160
    5. MondoA, a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network. Billin AN, et al. Mol Cell Biol, 2000 Dec. PMID 11073985, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. involved in control of hepatic L-type pyruvate kinase gene transcription
      Title: Regulation of rat hepatic L-pyruvate kinase promoter composition and activity by glucose, n-3 polyunsaturated fatty acids, and peroxisome proliferator-activated receptor-alpha agonist.
    2. ChREBP.Mlx is the principal transcription factor regulating glucose-responsive genes in the liver and coordinately regulates a family of genes required for glucose utilization and energy storage
      Title: ChREBP*Mlx is the principal mediator of glucose-induced gene expression in the liver.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within nucleocytoplasmic transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of glycolytic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of lipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription from RNA polymerase II promoter by glucose ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    max-like protein X
    Names
    MLX, MAX dimerization protein
    max-like factor protein
    transcription factor-like 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034112.1 → NP_001029284.1  max-like protein X

      See identical proteins and their annotated locations for NP_001029284.1

      Status: VALIDATED

      Source sequence(s)
      BI286092, BQ194554, CO560831, CO574572
      UniProtKB/TrEMBL
      A2VCV8
      Conserved Domains (1) summary
      cd19687
      Location:129 → 205
      bHLHzip_Mlx; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      86519517..86524607
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269439.1 → XP_063125509.1  max-like protein X isoform X3

      UniProtKB/TrEMBL
      F7F8B8

    2. XM_063269440.1 → XP_063125510.1  max-like protein X isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZVP0, F7F8B8
      Related
      ENSRNOP00000083006.1, ENSRNOT00000106512.2

    3. XM_006247362.5 → XP_006247424.1  max-like protein X isoform X4

      See identical proteins and their annotated locations for XP_006247424.1

      UniProtKB/TrEMBL
      A6HJ81, F7F8B8, Q2I1Y9, Q2I1Z0
      Related
      ENSRNOP00000027116.5, ENSRNOT00000027116.7
      Conserved Domains (1) summary
      cd19687
      Location:75 → 151
      bHLHzip_Mlx; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) and similar proteins

    4. XM_039086405.2 → XP_038942333.1  max-like protein X isoform X6

      UniProtKB/TrEMBL
      A0A8I6GJW1, A6HJ82, F7F8B8
      Related
      ENSRNOP00000091763.1, ENSRNOT00000119770.2
      Conserved Domains (1) summary
      cd19687
      Location:45 → 121
      bHLHzip_Mlx; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) and similar proteins

    5. XM_017597398.3 → XP_017452887.1  max-like protein X isoform X1

    6. XM_039086404.2 → XP_038942332.1  max-like protein X isoform X2

      UniProtKB/TrEMBL
      F7F8B8
      Conserved Domains (1) summary
      cd19687
      Location:99 → 175
      bHLHzip_Mlx; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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