Foxe1 forkhead box E1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Foxe1provided by RGD
Official Full Name: forkhead box E1provided by RGD
Primary source: RGD:621723
See related: EnsemblRapid:ENSRNOG00000023497 AllianceGenome:RGD:621723
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ttf-2
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including hard palate development; regulation of DNA-templated transcription; and soft palate development. Predicted to act upstream of or within several processes, including hair follicle morphogenesis; thyroid gland development; and thyroid hormone generation. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in Bamforth-Lazarus syndrome and papillary thyroid carcinoma. Orthologous to human FOXE1 (forkhead box E1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: 5q22

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (65425630..65428438)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (60630027..60632835)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (61954549..61957357)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification of Germline FOXE1 and Somatic MAPK Pathway Gene Alterations in Patients with Malignant Struma Ovarii, Cleft Palate and Thyroid Cancer.
Title: Identification of Germline FOXE1 and Somatic MAPK Pathway Gene Alterations in Patients with Malignant Struma Ovarii, Cleft Palate and Thyroid Cancer.
Nitric oxide decreases TSH-induced FoxE1 expression, thus repressing the transcripcional activation of TPO gene.
Title: Nitric oxide-repressed Forkhead factor FoxE1 expression is involved in the inhibition of TSH-induced thyroid peroxidase levels.
Nis and Duox2 are two novel direct transcriptional regulation FoxE1 targets in thyroid follicular cells.
Title: New insights into FoxE1 functions: identification of direct FoxE1 targets in thyroid cells.
Results suggest that FoxE1 is a pioneer factor whose primary mechanistic role in mediating the hormonal regulation of the thyroperoxidase gene is to enable other regulatory factors to access the chromatin.
Title: The forkhead factor FoxE1 binds to the thyroperoxidase promoter during thyroid cell differentiation and modifies compacted chromatin structure.

Submit: New GeneRIF Correction

General gene information

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Markers

PMC20962P1 (e-PCR)
- UniSTS:272004

RH131729 (e-PCR)
- UniSTS:215012

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell migration	ISO Inferred from Sequence Orthology more info
involved_in chordate pharynx development	ISO Inferred from Sequence Orthology more info
involved_in cranial skeletal system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic organ morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hair follicle morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in hard palate development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within roof of mouth development	ISO Inferred from Sequence Orthology more info
involved_in roof of mouth development	ISO Inferred from Sequence Orthology more info
involved_in soft palate development	ISO Inferred from Sequence Orthology more info
involved_in thymus development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within thyroid gland development	ISO Inferred from Sequence Orthology more info
involved_in thyroid gland development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within thyroid hormone generation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: forkhead box protein E1

Names: forkhead box E1 (thyroid transcription factor 2)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.