Zfp111 zinc finger protein 111 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zfp111provided by RGD
Official Full Name: zinc finger protein 111provided by RGD
Primary source: RGD:620595
See related: EnsemblRapid:ENSRNOG00000024376 AllianceGenome:RGD:620595
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: rKr2
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of DNA-templated transcription. Predicted to be active in nucleus. Orthologous to several human genes including ZNF235 (zinc finger protein 235). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 46.4), Brain (RPKM 41.0) and 9 other tissues See more
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Genomic context

Location:: 1q21

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (88890816..88902183, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (79762897..79774274, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (81035686..81046934, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A novel cellular protein, Zfp111, binds to the JSRV Env protein, and this binding plays a role in retroviral transformation.
Title: Role for a Zinc Finger Protein (Zfp111) in Transformation of 208F Rat Fibroblasts by Jaagsiekte Sheep Retrovirus Envelope Protein.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	NAS Non-traceable Author Statement more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: zinc finger protein 227

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133323.1 → NP_579857.1 zinc finger protein 227

See identical proteins and their annotated locations for NP_579857.1

Status: PROVISIONAL

Source sequence(s)

U27186

UniProtKB/TrEMBL

Q62788

Conserved Domains (5) summary

smart00349
Location:8 → 54

KRAB; krueppel associated box

COG5048
Location:306 → 721

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:632 → 652

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam01352
Location:8 → 47

KRAB; KRAB box

pfam13465
Location:672 → 697

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

88890816..88902183 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039084722.2 → XP_038940650.1 zinc finger protein 227 isoform X1

UniProtKB/TrEMBL

G3V9G6

Conserved Domains (3) summary

smart00349
Location:4 → 50

KRAB; krueppel associated box

COG5048
Location:302 → 717

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:628 → 648

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_063272638.1 → XP_063128708.1 zinc finger protein 227 isoform X2

UniProtKB/TrEMBL

A0A8I6G8Y2

Related

ENSRNOP00000046964.7, ENSRNOT00000051473.7