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    Gnpat glyceronephosphate O-acyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84470, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gnpatprovided by RGD
    Official Full Name
    glyceronephosphate O-acyltransferaseprovided by RGD
    Primary source
    RGD:620179
    See related
    EnsemblRapid:ENSRNOG00000019205 AllianceGenome:RGD:620179
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable glycerone-phosphate O-acyltransferase activity. Involved in several processes, including response to fatty acid; response to nutrient; and response to starvation. Located in peroxisomal membrane. Human ortholog(s) of this gene implicated in rhizomelic chondrodysplasia punctata type 2. Orthologous to human GNPAT (glyceronephosphate O-acyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 225.6), Muscle (RPKM 219.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gnpat in Genome Data Viewer
    Location:
    19q12
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (69719707..69746244)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (52822326..52848872)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (57614813..57640524)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene transfer RNA alanine (anticodon AGC) 43 Neighboring gene tripartite motif-containing 67 Neighboring gene 40S small subunit processome assembly factor 1 Neighboring gene exocyst complex component 8 Neighboring gene SprT-like N-terminal domain

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A study of the glycerol phosphate acyltransferase and dihydroxyacetone phosphate acyltransferase activities in rat liver mitochondrial and microsomal fractions. Relative distribution in parenchymal and non-parenchymal cells, effects of N-ethylmaleimide, palmitoyl-coenzyme A concentration, starvation, adrenalectomy and anti-insulin serum treatment. Bates EJ, et al. Biochem J, 1979 Sep 15. PMID 518562, Free PMC Article
    2. Studies of dihydroxyacetone phosphate acyltransferase in rat small intestine. Subcellular localization and effect of partially hydrogenated fish oil and clofibrate. Ruyter B, et al. Biochem J, 1992 Mar 1. PMID 1546971, Free PMC Article
    3. Effect of 3- and 4-thia-substituted fatty acids on glycerolipid metabolism and mitochondrial beta-oxidation in rat liver. Skorve J, et al. Biochem Pharmacol, 1990 Nov 1. PMID 2242030
    4. Defects in myelination, paranode organization and Purkinje cell innervation in the ether lipid-deficient mouse cerebellum. Teigler A, et al. Hum Mol Genet, 2009 Jun 1. PMID 19270340, Free PMC Article
    5. Role of dihydroxyacetonephosphate acyltransferase in the biosynthesis of plasmalogens and nonether glycerolipids. Liu D, et al. J Lipid Res, 2005 Apr. PMID 15687349

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables catalytic activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycerone-phosphate O-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycerone-phosphate O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerone-phosphate O-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycerone-phosphate O-acyltransferase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cerebellum morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ether lipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ether lipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ether lipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ether lipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycerophospholipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within membrane organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within myelination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within paranodal junction assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to fatty acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to nutrient IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within synapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisomal membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dihydroxyacetone phosphate acyltransferase
    Names
    DAP-AT
    DHAP-AT
    acyl-CoA:dihydroxyacetonephosphate acyltransferase
    acyl-CoA:dihydroxyacetonephosphateacyltransferase
    glycerone-phosphate O-acyltransferase
    NP_445862.1
    XP_038953970.2
    XP_038953971.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053410.2 → NP_445862.1  dihydroxyacetone phosphate acyltransferase

      See identical proteins and their annotated locations for NP_445862.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/Swiss-Prot
      Q9ES71
      UniProtKB/TrEMBL
      A0A8I5YBP7, A6KJ21
      Related
      ENSRNOP00000106897.1, ENSRNOT00000167276.1
      Conserved Domains (1) summary
      cd07993
      Location:133 → 338
      LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      69719707..69746244
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039098043.2 → XP_038953971.1  dihydroxyacetone phosphate acyltransferase isoform X2

      UniProtKB/TrEMBL
      A0A8I5YBP7
      Related
      ENSRNOP00000026617.5, ENSRNOT00000026617.8
      Conserved Domains (2) summary
      cd07993
      Location:83 → 288
      LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
      PTZ00374
      Location:17 → 474
      PTZ00374; dihydroxyacetone phosphate acyltransferase; Provisional

    2. XM_039098042.2 → XP_038953970.2  dihydroxyacetone phosphate acyltransferase isoform X1

      UniProtKB/TrEMBL
      A6KJ22
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ES71.1 GenPept UniProtKB/Swiss-Prot:Q9ES71

    Gene LinkOut

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