Cbr1 carbonyl reductase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cbr1provided by RGD
Official Full Name: carbonyl reductase 1provided by RGD
Primary source: RGD:2286
See related: AllianceGenome:RGD:2286
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cbr; PG-9-KR
Summary: Enables carbonyl reductase (NADPH) activity. Involved in several processes, including ovulation from ovarian follicle; phylloquinone catabolic process; and prostaglandin catabolic process. Located in microvillus. Biomarker of chronic kidney disease. Orthologous to human CBR1 (carbonyl reductase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 2109.0), Heart (RPKM 393.2) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q11

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (46346405..46348815)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (32860571..32862981)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (33813041..33815418)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In conclusion, hippocampal ACh release may specifically be controlled through CB1Rs located on both cholinergic and dopaminergic neuronal projections, and CB1R antagonism increases hippocampal ACh release.
Title: CB1 receptor antagonism increases hippocampal acetylcholine release: site and mechanism of action.
that the regulatory mechanism of the carbonyl reductase activity in rat liver microsomes is distinguishable from that in kidney microsomes
Title: Differential hormonal regulation of carbonyl reductase activities in liver and kidney microsomes of rat.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH129182 (e-PCR)
- UniSTS:212490

RH142185 (e-PCR)
- UniSTS:231435

BE099783 (e-PCR)
- UniSTS:261054

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 15-hydroxyprostaglandin dehydrogenase (NADP+) activity	ISS Inferred from Sequence or Structural Similarity more info
enables 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info
enables S-nitrosoglutathione reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info
enables carbonyl reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables carbonyl reductase (NADPH) activity	IDA Inferred from Direct Assay more info	PubMed
enables carbonyl reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info
enables carbonyl reductase (NADPH) activity	ISO Inferred from Sequence Orthology more info
enables carbonyl reductase (NADPH) activity	ISS Inferred from Sequence or Structural Similarity more info
enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	ISO Inferred from Sequence Orthology more info
enables prostaglandin E2 9-reductase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in glucocorticoid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in ovulation from ovarian follicle	IEP Inferred from Expression Pattern more info	PubMed
involved_in phylloquinone catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in response to estradiol	IDA Inferred from Direct Assay more info	PubMed
involved_in response to gonadotropin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to progesterone	IDA Inferred from Direct Assay more info	PubMed
involved_in response to testosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in steroid catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in vitamin K metabolic process	ISO Inferred from Sequence Orthology more info
involved_in vitamin K metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in xenobiotic metabolic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in microvillus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: carbonyl reductase [NADPH] 1

Names: 15-hydroxyprostaglandin dehydrogenase; 20-beta-hydroxysteroid dehydrogenase; NADPH-dependent carbonyl reductase 1; alcohol dehydrogenase [NAD(P)+] CBR1; prostaglandin 9-ketoreductase; prostaglandin-E(2) 9-reductase

NP_062043.2

EC 1.1.1.184

EC 1.1.1.189

EC 1.1.1.196

EC 1.1.1.197

EC 1.1.1.71

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019170.3 → NP_062043.2 carbonyl reductase [NADPH] 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/Swiss-Prot

O08558, P47727, Q3KR58

UniProtKB/TrEMBL

A6JLM2