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    Acp2 acid phosphatase 2, lysosomal [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24162, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Acp2provided by RGD
    Official Full Name
    acid phosphatase 2, lysosomalprovided by RGD
    Primary source
    RGD:2021
    See related
    EnsemblRapid:ENSRNOG00000013594 AllianceGenome:RGD:2021
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    LAP
    Summary
    The protein encoded by this gene belongs to the histidine acid phosphatase family, which hydrolyze orthophosphoric monoesters to alcohol and phosphate. This protein is localized to the lysosomal membrane, and is chemically and genetically distinct from the red cell acid phosphatase. Mice lacking this gene showed multiple defects, including bone structure alterations, lysosomal storage defects, and an increased tendency towards seizures. An enzymatically-inactive allele of this gene showed severe growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype. Two isoforms are predicted to be produced from the same mRNA by the use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. [provided by RefSeq, Oct 2017]
    Expression
    Biased expression in Liver (RPKM 164.8), Kidney (RPKM 156.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Acp2 in Genome Data Viewer
    Location:
    3q24
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (97630654..97642601)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (77175022..77185180)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (80020346..80030365)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene transfer RNA alanine (anticodon AGC) 34 Neighboring gene U6 spliceosomal RNA Neighboring gene nuclear receptor subfamily 1, group H, member 3 Neighboring gene damage specific DNA binding protein 2 Neighboring gene protein kinase C and casein kinase substrate in neurons 3 Neighboring gene ARF GTPase activating protein 2 Neighboring gene centriolar satellite-associated tubulin polyglutamylase complex regulator 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Isolation and sequencing of a cDNA clone encoding acid phosphatase in rat liver lysosomes. Himeno M, et al. Biochem Biophys Res Commun, 1989 Aug 15. PMID 2764916
    2. Synthesis and transport of lysosomal acid phosphatase in normal and I-cell fibroblasts. Lemansky P, et al. J Biol Chem, 1985 Jul 25. PMID 3160696
    3. Dephosphorylation of tyrosine phosphorylated synthetic peptides by rat liver phosphotyrosine protein phosphatase isoenzymes. Stefani M, et al. FEBS Lett, 1993 Jul 12. PMID 7686862
    4. Combined apoptosis and autophagy, the process that eliminates the oocytes of atretic follicles in immature rats. Escobar ML, et al. Apoptosis, 2008 Oct. PMID 18690537
    5. Kinetic studies on rat liver low M(r) phosphotyrosine protein phosphatases. The activation mechanism of the isoenzyme AcP2 by cGMP. Cirri P, et al. Biochim Biophys Acta, 1995 Jan 18. PMID 7827101

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables acid phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acid phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acid phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphoprotein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphotyrosine residue binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in autophagic cell death IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chemical synaptic transmission NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in lysosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lysosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to cGMP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within skeletal system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in lysosomal lumen IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lysosomal acid phosphatase
    Names
    Acid phosphatase 2, lysozymal
    LMW-PTP-II low molecular weight phosphotyrosine protein phosphatase isozyme 2
    NP_001344000.1
    NP_058684.2
    XP_006234562.1
    XP_063139142.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357071.1 → NP_001344000.1  lysosomal acid phosphatase isoform 1x precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UAG termination codon. This RefSeq represents the longer isoform (1x). As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), its location in the longer isoform is denoted by an 'X'.
      Source sequence(s)
      BC081823, CB720349
      UniProtKB/Swiss-Prot
      P20611
      Conserved Domains (1) summary
      cd07061
      Location:33 → 330
      HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

    2. NM_016988.2 → NP_058684.2  lysosomal acid phosphatase isoform 1 precursor

      See identical proteins and their annotated locations for NP_058684.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UAG termination codon. This RefSeq represents the shorter isoform (1).
      Source sequence(s)
      BC081823, CB720349
      UniProtKB/Swiss-Prot
      P20611
      UniProtKB/TrEMBL
      Q642D2
      Conserved Domains (1) summary
      cd07061
      Location:33 → 330
      HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      97630654..97642601
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283072.1 → XP_063139142.1  lysosomal acid phosphatase isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZST8
      Related
      ENSRNOP00000105616.1, ENSRNOT00000123449.1

    2. XM_006234500.4 → XP_006234562.1  lysosomal acid phosphatase isoform X2

      See identical proteins and their annotated locations for XP_006234562.1

      UniProtKB/TrEMBL
      A0A8I5ZST8, A6HNB5, F7F1A3
      Related
      ENSRNOP00000018620.3, ENSRNOT00000018620.6
      Conserved Domains (1) summary
      cd07061
      Location:69 → 366
      HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P20611.1 GenPept UniProtKB/Swiss-Prot:P20611

    Gene LinkOut

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