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    Mcm7 minichromosome maintenance complex component 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288532, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Mcm7provided by RGD
    Official Full Name
    minichromosome maintenance complex component 7provided by RGD
    Primary source
    RGD:1303018
    See related
    EnsemblRapid:ENSRNOG00000001349 AllianceGenome:RGD:1303018
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATP binding activity; ATP-dependent activity, acting on DNA; and DNA binding activity. Predicted to contribute to DNA helicase activity and single-stranded DNA binding activity. Involved in cellular response to epidermal growth factor stimulus and response to xenobiotic stimulus. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of CMG complex and MCM complex. Used to study hepatocellular carcinoma. Biomarker of hepatocellular carcinoma and hyperthyroidism. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human MCM7 (minichromosome maintenance complex component 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 521.1), Spleen (RPKM 289.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mcm7 in Genome Data Viewer
    Location:
    12q11
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (22155921..22163320, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (17042207..17049470, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (19306615..19313877, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene zinc finger and SCAN domain containing 21 Neighboring gene zinc finger protein 3 Neighboring gene COP9 signalosome subunit 6 Neighboring gene microRNA 106b Neighboring gene microRNA 25 Neighboring gene microRNA 93 Neighboring gene adaptor related protein complex 4 subunit mu 1 Neighboring gene TATA-box binding protein associated factor 6 Neighboring gene canopy FGF signaling regulator 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Atorvastatin inhibits expression of minichromosome maintenance proteins in vascular smooth muscle cells. Bruemmer D, et al. Eur J Pharmacol, 2003 Feb 21. PMID 12591091
    2. Peroxisome proliferator-activated receptor gamma inhibits expression of minichromosome maintenance proteins in vascular smooth muscle cells. Bruemmer D, et al. Mol Endocrinol, 2003 Jun. PMID 12677008
    3. MCM7 expression is altered in rat after spinal cord injury. Chen J, et al. J Mol Neurosci, 2013 Sep. PMID 23526403
    4. Gene expression profiling of microdissected pancreatic ductal carcinomas using high-density DNA microarrays. Grützmann R, et al. Neoplasia, 2004 Sep-Oct. PMID 15548371, Free PMC Article
    5. Identification, molecular cloning, and cellular distribution of the rat homolog of minichromosome maintenance protein 7 (MCM7) in the rat testis. Com E, et al. Mol Reprod Dev, 2006 Jul. PMID 16557521

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MCM7 expression and distribution change in injured spinal cord tissue.
      Title: MCM7 expression is altered in rat after spinal cord injury.
    2. The study describes the cellular distribution of Minichromosome Maintenance Protein 7, MCM7 transcripts and protein, and their testicular ontogenetic expression.
      Title: Identification, molecular cloning, and cellular distribution of the rat homolog of minichromosome maintenance protein 7 (MCM7) in the rat testis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93853

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent activity, acting on DNA TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables DNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    contributes_to DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA replication TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within DNA unwinding involved in DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA unwinding involved in DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to epidermal growth factor stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CMG complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of MCM complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA replication licensing factor MCM7
    Names
    minichromosome maintenance deficient 7
    minichromosome maintenance protein 7
    NP_001004203.3
    XP_006249067.1
    XP_006249068.1
    XP_063127213.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004203.3 → NP_001004203.3  DNA replication licensing factor MCM7

      See identical proteins and their annotated locations for NP_001004203.3

      Status: PROVISIONAL

      Source sequence(s)
      BC078973
      UniProtKB/TrEMBL
      A0A8I5Y509, A6KSS8, Q1PS21, Q6AYN8
      Related
      ENSRNOP00000076814.1, ENSRNOT00000105826.2
      Conserved Domains (3) summary
      smart00350
      Location:145 → 641
      MCM; minichromosome maintenance proteins
      pfam14551
      Location:12 → 165
      MCM_N; MCM N-terminal domain
      cl21455
      Location:376 → 515
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      22155921..22163320 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006249006.5 → XP_006249068.1  DNA replication licensing factor MCM7 isoform X2

      See identical proteins and their annotated locations for XP_006249068.1

      UniProtKB/TrEMBL
      A6KST0, F7F0X7
      Conserved Domains (1) summary
      smart00350
      Location:38 → 534
      MCM; minichromosome maintenance proteins

    2. XM_006249005.5 → XP_006249067.1  DNA replication licensing factor MCM7 isoform X2

      See identical proteins and their annotated locations for XP_006249067.1

      UniProtKB/TrEMBL
      A6KST0, F7F0X7
      Conserved Domains (1) summary
      smart00350
      Location:38 → 534
      MCM; minichromosome maintenance proteins

    3. XM_063271143.1 → XP_063127213.1  DNA replication licensing factor MCM7 isoform X1

      UniProtKB/TrEMBL
      Q1PS21
    Nucleotide Protein Strain
    Heading Accession and Version

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