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    Egfl7 EGF-like-domain, multiple 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 245963, updated on 9-Dec-2024

    Summary

    Official Symbol
    Egfl7provided by RGD
    Official Full Name
    EGF-like-domain, multiple 7provided by RGD
    Primary source
    RGD:708507
    See related
    EnsemblRapid:ENSRNOG00000019388 AllianceGenome:RGD:708507
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable Notch binding activity. Predicted to be involved in vasculogenesis. Predicted to act upstream of or within negative regulation of Notch signaling pathway; negative regulation of smooth muscle cell migration; and positive regulation of endothelial cell proliferation. Predicted to be located in extracellular space. Predicted to be active in cell surface and extracellular region. Orthologous to human EGFL7 (EGF like domain multiple 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 876.4), Heart (RPKM 373.5) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Egfl7 in Genome Data Viewer
    Location:
    3p13
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (29802481..29814966)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (9404622..9416879)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (4034759..4044280)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101512 Neighboring gene RNA, U6 small nuclear 198 Neighboring gene microRNA 126a Neighboring gene microRNA 126b Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 2 Neighboring gene divergent protein kinase domain 1B Neighboring gene uncharacterized LOC100911266 Neighboring gene small nucleolar RNA SNORA43

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Clone Names

    • MGC93163

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables Notch binding  
    enables calcium ion binding  
    enables signaling receptor binding  
    Process Evidence Code Pubs
    involved_in angiogenesis  
    involved_in blood vessel development  
    involved_in blood vessel development  
    involved_in cell adhesion  
    involved_in negative regulation of Notch signaling pathway  
    acts_upstream_of_or_within negative regulation of Notch signaling pathway  
    acts_upstream_of_or_within negative regulation of smooth muscle cell migration  
    involved_in positive regulation of endothelial cell proliferation  
    acts_upstream_of_or_within positive regulation of endothelial cell proliferation  
    acts_upstream_of smooth muscle cell migration  
    involved_in vasculogenesis  
    involved_in vasculogenesis  
    involved_in vasculogenesis  
    Component Evidence Code Pubs
    is_active_in cell surface  
    is_active_in extracellular region  
    located_in extracellular region  
    located_in extracellular region  
    located_in extracellular space  

    General protein information

    Preferred Names
    epidermal growth factor-like protein 7
    Names
    EGF-like domain 7
    EGF-like domain-containing protein 7
    EGF-like protein 7
    Estrogen-regulated protein CBL20, 20.4kD
    multiple EGF-like domain protein 7
    multiple EGF-like domains protein 7
    multiple epidermal growth factor-like domain protein 7
    multiple epidermal growth factor-like domains protein 7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399187.1NP_001386116.1  epidermal growth factor-like protein 7 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q6AZ60, Q9JKW3
      UniProtKB/TrEMBL
      A0A8L2QF53, A6JTF9
      Related
      ENSRNOP00000026318.6, ENSRNOT00000026318.8
      Conserved Domains (2) summary
      pfam07645
      Location:145184
      EGF_CA; Calcium-binding EGF domain
      pfam07546
      Location:32101
      EMI; EMI domain
    2. NM_001399188.1NP_001386117.1  epidermal growth factor-like protein 7 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q6AZ60, Q9JKW3
      UniProtKB/TrEMBL
      A0A8L2QF53, A6JTF9
      Related
      ENSRNOP00000088876.2, ENSRNOT00000107620.2
      Conserved Domains (2) summary
      pfam07645
      Location:145184
      EGF_CA; Calcium-binding EGF domain
      pfam07546
      Location:32101
      EMI; EMI domain

    RNA

    1. NR_174164.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      29802481..29814966
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104248.2XP_038960176.1  epidermal growth factor-like protein 7 isoform X1

      UniProtKB/Swiss-Prot
      Q6AZ60, Q9JKW3
      UniProtKB/TrEMBL
      A0A8L2QF53, A6JTF9
      Related
      ENSRNOP00000081631.2, ENSRNOT00000115008.2
      Conserved Domains (2) summary
      pfam07645
      Location:145184
      EGF_CA; Calcium-binding EGF domain
      pfam07546
      Location:32101
      EMI; EMI domain
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