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    Shd src homology 2 domain-containing transforming protein D [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316507, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Shdprovided by RGD
    Official Full Name
    src homology 2 domain-containing transforming protein Dprovided by RGD
    Primary source
    RGD:1590885
    See related
    EnsemblRapid:ENSRNOG00000049983 AllianceGenome:RGD:1590885
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphotyrosine residue binding activity. Orthologous to human SHD (Src homology 2 domain containing transforming protein D). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 43.7), Adrenal (RPKM 41.7) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Shd in Genome Data Viewer
    Location:
    9q11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (888865..895557)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (799652..809769)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (11090048..11098813, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S21, pseudogene 2 Neighboring gene Epstein-Barr virus induced 3 Neighboring gene uncharacterized LOC134480467 Neighboring gene YJU2 splicing factor Neighboring gene fibronectin type III and SPRY domain containing 1 Neighboring gene signal transducing adaptor family member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphotyrosine residue binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SH2 domain-containing adapter protein D

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108223.1 → NP_001101693.1  SH2 domain-containing adapter protein D

      See identical proteins and their annotated locations for NP_001101693.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474092
      UniProtKB/TrEMBL
      A0A8I6ACG0, B0BN15
      Related
      ENSRNOP00000065655.3, ENSRNOT00000074767.4
      Conserved Domains (1) summary
      cl15255
      Location:223 → 320
      SH2; Src homology 2 (SH2) domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      888865..895557
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083665.2 → XP_038939593.1  SH2 domain-containing adapter protein D isoform X1

      UniProtKB/TrEMBL
      M0R864
      Conserved Domains (1) summary
      cl15255
      Location:224 → 321
      SH2; Src homology 2 (SH2) domain

    2. XM_039083666.2 → XP_038939594.1  SH2 domain-containing adapter protein D isoform X2

      Conserved Domains (1) summary
      cl15255
      Location:117 → 214
      SH2; Src homology 2 (SH2) domain
    Nucleotide Protein Strain
    Heading Accession and Version

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