Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gabbr1provided by RGD
Official Full Name: gamma-aminobutyric acid type B receptor subunit 1provided by RGD
Primary source: RGD:621537
See related: EnsemblRapid:ENSRNOG00000000774 AllianceGenome:RGD:621537
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables G protein-coupled GABA receptor activity; extracellular matrix protein binding activity; and protein heterodimerization activity. Involved in several processes, including negative regulation of adenylate cyclase activity; neuron-glial cell signaling; and regulation of secretion. Acts upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway. Located in several cellular components, including axolemma; dendrite; and synaptic vesicle. Part of GABA receptor complex. Is active in GABA-ergic synapse; glutamatergic synapse; and synaptic membrane. Used to study alcohol dependence. Biomarker of hypertension. Human ortholog(s) of this gene implicated in alcohol dependence; amphetamine abuse; cocaine dependence; heroin dependence; and nicotine dependence. Orthologous to human GABBR1 (gamma-aminobutyric acid type B receptor subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 682.3), Thymus (RPKM 73.1) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (1469779..1499352, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (1464534..1494114, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (1955344..1984907, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GABABR1 in DRN mediated GABA to regulate 5-HT expression in multiple brain regions in male rats with high and low aggressive behavior.
Title: GABABR1 in DRN mediated GABA to regulate 5-HT expression in multiple brain regions in male rats with high and low aggressive behavior.
GABABR Modulation of Electrical Synapses and Plasticity in the Thalamic Reticular Nucleus.
Title: GABA(B)R Modulation of Electrical Synapses and Plasticity in the Thalamic Reticular Nucleus.
GABAB Receptor-Mediated PI3K/Akt Signaling Pathway Alleviates Oxidative Stress and Neuronal Cell Injury in a Rat Model of Alzheimer's Disease.
Title: GABAB Receptor-Mediated PI3K/Akt Signaling Pathway Alleviates Oxidative Stress and Neuronal Cell Injury in a Rat Model of Alzheimer's Disease.
Presynaptic GABAB receptors underlie the antiepileptic effect of low-frequency electrical stimulation in the 4-aminopyridine model of epilepsy in brain slices of young rats.
Title: Presynaptic GABA(B) receptors underlie the antiepileptic effect of low-frequency electrical stimulation in the 4-aminopyridine model of epilepsy in brain slices of young rats.
Transient activation of mGluRs decreased the GIRK current evoked by GABAB and D2 receptors, although less efficaciously for D2.
Title: Calcium Release from Stores Inhibits GIRK.
We demonstrate that GABABR activation can regulate KCC2 at the cell surface in a manner that alters intracellular chloride and the reversal potential for the GABAAR. Our data therefore support an additional mechanism by which GABABRs are able to modulate fast synaptic inhibition.
Title: Neuronal Chloride Regulation via KCC2 Is Modulated through a GABA(B) Receptor Protein Complex.
sustained activation of glutamate receptors, a condition occurring in brain ischemia that down-regulates GABAB receptors, considerably increased the expression of MIB2 and Lys-63-linked ubiquitination of GABAB receptors. Interfering with Lys-63-linked ubiquitination by overexpressing ubiquitin mutants or GABAB1 mutants deficient in Lys-63-linked ubiquitination prevented glutamate-induced down-regulation of the receptors.
Title: Lys-63-linked Ubiquitination of γ-Aminobutyric Acid (GABA), Type B1, at Multiple Sites by the E3 Ligase Mind Bomb-2 Targets GABAB Receptors to Lysosomal Degradation.
Both synaptic processes were critically dependent on activation of GABAB receptors and, together, appeared to temporally segregate the cortical representation. These data suggest that adaptation to repetitive sensory input dramatically alters the spatiotemporal properties of the neocortical response in a manner that may both refine and minimize cortical output simultaneously.
Title: GABAB receptor-mediated, layer-specific synaptic plasticity reorganizes gamma-frequency neocortical response to stimulation.
that in the mammalian neuromuscular synapse, metabotropic GABAB receptors are expressed and their activation results in a reduction in the intensity of acetylcholine release
Title: Metabotropic GABAB receptors mediate GABA inhibition of acetylcholine release in the rat neuromuscular junction.
ANG II/AT1R/HoxD10/miR-7b/GABBR1 pathway in the PVN contributes to sympathoexcitation and deterioration of cardiac function in heart failure.
Title: Sympathoexcitation in Rats With Chronic Heart Failure Depends on Homeobox D10 and MicroRNA-7b Inhibiting GABBR1 Translation in Paraventricular Nucleus.

Submit: New GeneRIF Correction See all GeneRIFs (95)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH133825 (e-PCR)
- UniSTS:217108

Gabbr1 (e-PCR), detects polymorphism
- UniSTS:525645

RH138703 (e-PCR)
- UniSTS:220790

RH136700 (e-PCR)
- UniSTS:218789

UniSTS:496042 (e-PCR)
- UniSTS:496042

Gabbr1 (e-PCR), detects polymorphism
- UniSTS:496042

D20Wox20 (e-PCR)
- UniSTS:518646

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled GABA receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled GABA receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled GABA receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
contributes_to G protein-coupled GABA receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled GABA receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	ISO Inferred from Sequence Orthology more info
enables G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential	ISO Inferred from Sequence Orthology more info
enables extracellular matrix protein binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in gamma-aminobutyric acid signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in gamma-aminobutyric acid signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within gamma-aminobutyric acid signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in gamma-aminobutyric acid signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in gamma-aminobutyric acid signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of adenylate cyclase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of dopamine secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of epinephrine secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gamma-aminobutyric acid secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron-glial cell signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glutamate secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of growth hormone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of glutamate secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nicotine	IEP Inferred from Expression Pattern more info	PubMed
involved_in synaptic transmission, GABAergic	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of G protein-coupled GABA receptor complex	ISO Inferred from Sequence Orthology more info
part_of G protein-coupled receptor dimeric complex	ISO Inferred from Sequence Orthology more info
part_of G protein-coupled receptor heterodimeric complex	IBA Inferred from Biological aspect of Ancestor more info
part_of G protein-coupled receptor heterodimeric complex	ISO Inferred from Sequence Orthology more info
part_of G protein-coupled receptor heterodimeric complex	ISS Inferred from Sequence or Structural Similarity more info
part_of GABA receptor complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in axolemma	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendritic shaft	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in presynapse	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: gamma-aminobutyric acid type B receptor subunit 1

Names: GABA-B receptor 1; GABA-B-R1; GABA-BR1; GABABR1; gamma-aminobutyric acid (GABA) B receptor 1; gb1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031028.3 → NP_112290.2 gamma-aminobutyric acid type B receptor subunit 1 precursor

See identical proteins and their annotated locations for NP_112290.2

Status: VALIDATED

Source sequence(s)

BX883052

UniProtKB/Swiss-Prot

O08620, O08621, Q9Z0F9, Q9Z0U4, Q9Z308

UniProtKB/TrEMBL

A0A0A0MY30, A6KR59, Q6MFX8

Related

ENSRNOP00000071413.2, ENSRNOT00000090936.4

Conserved Domains (5) summary

cd06366
Location:170 → 562

PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)

pfam00003
Location:602 → 856

7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

pfam00084
Location:106 → 156

Sushi; Sushi repeat (SCR repeat)

pfam01094
Location:186 → 542

ANF_receptor; Receptor family ligand binding region

pfam10211
Location:884 → 926

Ax_dynein_light; Axonemal dynein light chain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

1469779..1499352 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039099118.2 → XP_038955046.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X2

UniProtKB/TrEMBL

A0A9K3Y6U0, A6KR60, F7FE05, Q924M0

Related

ENSRNOP00000098098.2, ENSRNOT00000120416.2

Conserved Domains (3) summary

cd15291
Location:582 → 885

7tmC_GABA-B-R1; gamma-aminobutyric acid type B receptor subunit 1, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06366
Location:163 → 562

PBP1_GABAb_receptor; ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)

pfam00084
Location:106 → 156

Sushi; Sushi repeat (SCR repeat)
XM_006255879.5 → XP_006255941.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X1

See identical proteins and their annotated locations for XP_006255941.1

UniProtKB/TrEMBL

A6KR60

Related

ENSRNOP00000075181.4, ENSRNOT00000085050.4

Conserved Domains (5) summary

cd06366
Location:170 → 562

PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)

pfam00003
Location:602 → 887

7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

pfam00084
Location:106 → 156

Sushi; Sushi repeat (SCR repeat)

pfam01094
Location:186 → 542

ANF_receptor; Receptor family ligand binding region

pfam10211
Location:915 → 957

Ax_dynein_light; Axonemal dynein light chain
XM_063279560.1 → XP_063135630.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X3

UniProtKB/TrEMBL

A6KR59

Related

ENSRNOP00000072226.2, ENSRNOT00000088396.4