Kazald1 Kazal-type serine peptidase inhibitor domain 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kazald1provided by RGD
Official Full Name: Kazal-type serine peptidase inhibitor domain 1provided by RGD
Primary source: RGD:1310698
See related: EnsemblRapid:ENSRNOG00000016058 AllianceGenome:RGD:1310698
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable insulin-like growth factor binding activity. Predicted to be involved in regulation of signal transduction. Predicted to act upstream of or within extracellular matrix organization. Predicted to be located in extracellular matrix. Predicted to be active in extracellular space and interstitial matrix. Orthologous to human KAZALD1 (Kazal type serine peptidase inhibitor domain 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 142.9), Heart (RPKM 38.6) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q54

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (253888639..253892211)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (243939596..243943060)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (264827739..264831152)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH143795 (e-PCR)
- UniSTS:233041

BE099439 (e-PCR)
- UniSTS:245661

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables insulin-like growth factor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within extracellular matrix organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell growth	IEA Inferred from Electronic Annotation more info
involved_in regulation of signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in interstitial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in interstitial matrix	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: kazal-type serine protease inhibitor domain-containing protein 1

Names: Kazal-type serine protease inhibitor domain 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033064.1 → NP_001028236.1 kazal-type serine protease inhibitor domain-containing protein 1 precursor

See identical proteins and their annotated locations for NP_001028236.1

Status: PROVISIONAL

Source sequence(s)

BC103652

UniProtKB/TrEMBL

F7FQ17, Q3ZAU4

Related

ENSRNOP00000021553.5, ENSRNOT00000021553.7

Conserved Domains (4) summary

cd00096
Location:189 → 267

Ig; Immunoglobulin domain

cd00104
Location:129 → 168

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

pfam07679
Location:172 → 270

I-set; Immunoglobulin I-set domain

pfam00219
Location:54 → 108

IGFBP; Insulin-like growth factor binding protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

253888639..253892211

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039109068.2 → XP_038964996.1 kazal-type serine protease inhibitor domain-containing protein 1 isoform X1

Conserved Domains (4) summary

cd00104
Location:129 → 168

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

pfam00219
Location:54 → 108

IGFBP; Insulin-like growth factor binding protein

cd00096
Location:177 → 183

Ig; Ig strand A' [structural motif]

cl11960
Location:175 → 218

Ig; Immunoglobulin domain