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    Flad1 flavin adenine dinucleotide synthetase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 751787, updated on 9-Dec-2024

    Summary

    Official Symbol
    Flad1provided by RGD
    Official Full Name
    flavin adenine dinucleotide synthetase 1provided by RGD
    Primary source
    RGD:1593292
    See related
    EnsemblRapid:ENSRNOG00000020642 AllianceGenome:RGD:1593292
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable FMN adenylyltransferase activity and identical protein binding activity. Predicted to be involved in FAD biosynthetic process and riboflavin metabolic process. Predicted to be located in mitochondrion and plasma membrane. Predicted to be active in cytosol. Orthologous to human FLAD1 (flavin adenine dinucleotide synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 169.8), Muscle (RPKM 138.9) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Flad1 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (177117183..177126650, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (174819451..174828921, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (188726994..188736462, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene DC-STAMP domain containing 1 Neighboring gene DC-STAMP domain containing 2 Neighboring gene zinc finger and BTB domain containing 7B Neighboring gene lens epithelial protein Neighboring gene CDC28 protein kinase regulatory subunit 1B Neighboring gene SHC adaptor protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Clone Names

    • MGC187714

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables FMN adenylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables FMN adenylyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in FAD biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in FAD biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in FAD biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in flavin adenine dinucleotide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in riboflavin metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    FAD synthase
    Names
    FAD-synthetase
    NP_001103608.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110138.1NP_001103608.1  FAD synthase

      Status: PROVISIONAL

      Source sequence(s)
      BC107653
      UniProtKB/TrEMBL
      B1WBY2, D4A4P4
      Related
      ENSRNOP00000028030.4, ENSRNOT00000028030.7
      Conserved Domains (3) summary
      COG1058
      Location:13249
      CinA; Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]
      cd00885
      Location:15169
      cinA; Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of ...
      cd01713
      Location:301451
      PAPS_reductase; This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      177117183..177126650 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)