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    Fbxw4 F-box and WD repeat domain containing 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309444, updated on 9-Dec-2024

    Summary

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    Symbol
    Fbxw4provided by RGD
    Full Name
    F-box and WD repeat domain containing 4provided by RGD
    Primary source
    RGD:1306518
    See related
    EnsemblRapid:ENSRNOG00000046211 AllianceGenome:RGD:1306518
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within cartilage development; embryonic digit morphogenesis; and positive regulation of mesenchymal cell proliferation. Predicted to be part of SCF ubiquitin ligase complex. Orthologous to human FBXW4 (F-box and WD repeat domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 129.4), Lung (RPKM 121.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fbxw4 in Genome Data Viewer
    Location:
    1q54
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (254375921..254465173, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (244426892..244514188, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (265318526..265420503, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene DNA polymerase lambda Neighboring gene deleted in primary ciliary dyskinesia Neighboring gene uncharacterized LOC102550220 Neighboring gene fibroblast growth factor 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel member of the F-box/WD40 gene family, encoding dactylin, is disrupted in the mouse dactylaplasia mutant. Sidow A, et al. Nat Genet, 1999 Sep. PMID 10471509
    2. Defect in the maintenance of the apical ectodermal ridge in the Dactylaplasia mouse. Crackower MA, et al. Dev Biol, 1998 Sep 1. PMID 9733575
    3. Mapping the mouse dactylaplasia mutation, Dac, and a gene that controls its expression, mdac. Johnson KR, et al. Genomics, 1995 Sep 20. PMID 8666395
    4. Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. Ebstein F, et al. Int J Biochem Cell Biol, 2009 May. PMID 19028597
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cartilage development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryonic digit morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within limb development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    F-box/WD repeat-containing protein 4
    Names
    F-box and WD-40 domain protein 4
    F-box/WD repeat-containing protein 4-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107600.1 → NP_001101070.1  F-box/WD repeat-containing protein 4

      See identical proteins and their annotated locations for NP_001101070.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473986
      UniProtKB/TrEMBL
      A6JHI7
      Conserved Domains (4) summary
      COG2319
      Location:154 → 363
      WD40; WD40 repeat [General function prediction only]
      pfam12937
      Location:24 → 65
      F-box-like; F-box-like
      sd00039
      Location:202 → 238
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:148 → 387
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      254375921..254465173 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039080412.2 → XP_038936340.1  F-box/WD repeat-containing protein 4 isoform X7

      Conserved Domains (2) summary
      pfam12937
      Location:233 → 274
      F-box-like
      cl29593
      Location:313 → 419
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_039080406.2 → XP_038936334.1  F-box/WD repeat-containing protein 4 isoform X5

      Conserved Domains (3) summary
      sd00039
      Location:363 → 400
      7WD40; WD40 repeat [structural motif]
      pfam12937
      Location:233 → 274
      F-box-like
      cl29593
      Location:313 → 466
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. XM_039080399.2 → XP_038936327.1  F-box/WD repeat-containing protein 4 isoform X1

      UniProtKB/TrEMBL
      D4A2V7, M0RCK6
      Conserved Domains (3) summary
      sd00039
      Location:371 → 403
      7WD40; WD40 repeat [structural motif]
      pfam12937
      Location:233 → 274
      F-box-like
      cl29593
      Location:313 → 549
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. XM_063264895.1 → XP_063120965.1  F-box/WD repeat-containing protein 4 isoform X2

      UniProtKB/TrEMBL
      D4A2V7, M0RCK6
      Related
      ENSRNOP00000067326.3, ENSRNOT00000072223.4

    5. XM_063264923.1 → XP_063120993.1  F-box/WD repeat-containing protein 4 isoform X8

    6. XM_039080400.2 → XP_038936328.1  F-box/WD repeat-containing protein 4 isoform X3

      Conserved Domains (3) summary
      sd00039
      Location:371 → 403
      7WD40; WD40 repeat [structural motif]
      pfam12937
      Location:233 → 274
      F-box-like
      cl29593
      Location:313 → 436
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    7. XM_039080404.2 → XP_038936332.1  F-box/WD repeat-containing protein 4 isoform X4

      Conserved Domains (3) summary
      sd00039
      Location:371 → 403
      7WD40; WD40 repeat [structural motif]
      pfam12937
      Location:233 → 274
      F-box-like
      cl29593
      Location:313 → 485
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    8. XM_039080409.2 → XP_038936337.1  F-box/WD repeat-containing protein 4 isoform X6

      Conserved Domains (3) summary
      sd00039
      Location:371 → 403
      7WD40; WD40 repeat [structural motif]
      pfam12937
      Location:233 → 274
      F-box-like
      cl29593
      Location:359 → 459
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. XR_010053929.1 RNA Sequence

    2. XR_010053930.1 RNA Sequence

    3. XR_005487442.2 RNA Sequence

    4. XR_005487444.2 RNA Sequence

    5. XR_010053932.1 RNA Sequence

    6. XR_010053931.1 RNA Sequence

    7. XR_005487446.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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