Nme4 NME/NM23 nucleoside diphosphate kinase 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nme4provided by RGD
Official Full Name: NME/NM23 nucleoside diphosphate kinase 4provided by RGD
Primary source: RGD:1591334
See related: EnsemblRapid:ENSRNOG00000075475 AllianceGenome:RGD:1591334
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables GTPase binding activity. Predicted to be involved in lipid transport. Predicted to be located in mitochondrial intermembrane space. Predicted to be part of ribonucleoprotein complex. Orthologous to human NME4 (NME/NM23 nucleoside diphosphate kinase 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 115.1), Heart (RPKM 69.8) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (15619106..15622961, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (15114624..15118479, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (15461567..15465422, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nm23-H4 acts as a lipid-dependent mitochondrial switch with dual function in phosphotransfer serving local GTP supply and cardiolipin transfer for apoptotic signaling and putative other functions
Title: Dual function of mitochondrial Nm23-H4 protein in phosphotransfer and intermembrane lipid transfer: a cardiolipin-dependent switch.
NM23-H4 binds the inner mitochondrial membrane with high affinity to cardiolipin and couples nucleotide transfer with respiration
Title: The nucleoside diphosphate kinase D (NM23-H4) binds the inner mitochondrial membrane with high affinity to cardiolipin and couples nucleotide transfer with respiration.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 2,4-dienoyl-CoA reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GTPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables cardiolipin binding	ISO Inferred from Sequence Orthology more info
enables nucleoside diphosphate kinase activity	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of ribosome	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in CTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in GTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in UTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid transport	ISO Inferred from Sequence Orthology more info
involved_in translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial intermembrane space	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
located_in ribosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nucleoside diphosphate kinase, mitochondrial

Names: expressed in non-metastatic cells 4, protein; non-metastatic cells 4, protein expressed in; nucleoside diphosphate kinase 4

NP_001102948.1

EC 2.7.4.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109478.1 → NP_001102948.1 nucleoside diphosphate kinase, mitochondrial

See identical proteins and their annotated locations for NP_001102948.1

Status: PROVISIONAL

Source sequence(s)

CH473948

UniProtKB/TrEMBL

A6HD87, D3ZMT9

Related

ENSRNOP00000027593.5, ENSRNOT00000027593.8

Conserved Domains (1) summary

cd04413
Location:36 → 165

NDPk_I; Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside ...