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    Zbtb17 zinc finger and BTB domain containing 17 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313666, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zbtb17provided by RGD
    Official Full Name
    zinc finger and BTB domain containing 17provided by RGD
    Primary source
    RGD:1307143
    See related
    EnsemblRapid:ENSRNOG00000010436 AllianceGenome:RGD:1307143
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Zfp100
    Summary
    Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; transcription cis-regulatory region binding activity; and transcription coactivator binding activity. Predicted to be involved in negative regulation of cell population proliferation; regulation of gene expression; and regulation of immune system process. Predicted to act upstream of with a negative effect on G1 to G0 transition. Predicted to act upstream of or within ectoderm development; gastrulation with mouth forming second; and positive regulation of DNA-templated transcription. Predicted to be located in nucleus. Predicted to be part of protein-DNA complex. Predicted to be active in nucleoplasm. Orthologous to human ZBTB17 (zinc finger and BTB domain containing 17). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 94.0), Muscle (RPKM 66.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zbtb17 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (159036482..159057580)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (153753508..153774613)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (159993799..160014899)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene transfer RNA proline (anticodon AGG) 71 Neighboring gene heat shock protein family B (small) member 7 Neighboring gene steroid receptor associated and regulated protein Neighboring gene spen family transcriptional repressor Neighboring gene filamin binding LIM protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An alternative pathway for gene regulation by Myc. Peukert K, et al. EMBO J, 1997 Sep 15. PMID 9312026, Free PMC Article
    2. Host cell factor-1 interacts with and antagonizes transactivation by the cell cycle regulatory factor Miz-1. Piluso D, et al. J Biol Chem, 2002 Nov 29. PMID 12244100
    3. Innate immunity to intraphagosomal pathogens is mediated by interferon regulatory factor 8 (IRF-8) that stimulates the expression of macrophage-specific Nramp1 through antagonizing repression by c-Myc. Alter-Koltunoff M, et al. J Biol Chem, 2008 Feb 1. PMID 18045875
    4. Miz1 is required for early embryonic development during gastrulation. Adhikary S, et al. Mol Cell Biol, 2003 Nov. PMID 14560010, Free PMC Article
    5. A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth. Wanzel M, et al. Nat Cell Biol, 2008 Sep. PMID 19160485

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables core promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_negative_effect G1 to G0 transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ectoderm development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within gastrulation with mouth forming second ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-DNA complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 17
    Names
    zinc finger protein 100

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012105.1 → NP_001012105.1  zinc finger and BTB domain-containing protein 17

      See identical proteins and their annotated locations for NP_001012105.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083577
      UniProtKB/TrEMBL
      Q5XIU3
      Related
      ENSRNOP00000102698.1, ENSRNOT00000152797.1
      Conserved Domains (7) summary
      smart00225
      Location:25 → 109
      BTB; Broad-Complex, Tramtrack and Bric a brac
      COG5048
      Location:304 → 635
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:474 → 494
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:614 → 633
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:304 → 326
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:14 → 109
      BTB; BTB/POZ domain
      pfam13465
      Location:318 → 342
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      159036482..159057580
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287815.1 → XP_063143885.1  zinc finger and BTB domain-containing protein 17 isoform X1

      UniProtKB/TrEMBL
      F7FQA4

    2. XM_063287819.1 → XP_063143889.1  zinc finger and BTB domain-containing protein 17 isoform X2

      UniProtKB/TrEMBL
      A6ITU0

    3. XM_063287816.1 → XP_063143886.1  zinc finger and BTB domain-containing protein 17 isoform X2

      UniProtKB/TrEMBL
      A6ITU0

    4. XM_063287818.1 → XP_063143888.1  zinc finger and BTB domain-containing protein 17 isoform X2

      UniProtKB/TrEMBL
      A6ITU0

    5. XM_039110080.2 → XP_038966008.1  zinc finger and BTB domain-containing protein 17 isoform X1

      UniProtKB/TrEMBL
      F7FQA4
      Conserved Domains (4) summary
      COG5048
      Location:322 → 653
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:492 → 512
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:632 → 651
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18206
      Location:2 → 113
      BTB_POZ_ZBTB17_MIZ1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17)

    6. XM_063287817.1 → XP_063143887.1  zinc finger and BTB domain-containing protein 17 isoform X2

      UniProtKB/TrEMBL
      A6ITU0

    7. XM_039110079.2 → XP_038966007.1  zinc finger and BTB domain-containing protein 17 isoform X1

      UniProtKB/TrEMBL
      F7FQA4
      Related
      ENSRNOP00000014399.5, ENSRNOT00000014399.9
      Conserved Domains (4) summary
      COG5048
      Location:322 → 653
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:492 → 512
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:632 → 651
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18206
      Location:2 → 113
      BTB_POZ_ZBTB17_MIZ1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17)

    8. XM_006239303.2 → XP_006239365.1  zinc finger and BTB domain-containing protein 17 isoform X2

      See identical proteins and their annotated locations for XP_006239365.1

      UniProtKB/TrEMBL
      A6ITU0
      Conserved Domains (7) summary
      smart00225
      Location:25 → 109
      BTB; Broad-Complex, Tramtrack and Bric a brac
      COG5048
      Location:297 → 628
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:467 → 487
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:607 → 626
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:297 → 319
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:14 → 109
      BTB; BTB/POZ domain
      pfam13465
      Location:311 → 335
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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