Glp1r glucagon-like peptide 1 receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Glp1rprovided by RGD
Official Full Name: glucagon-like peptide 1 receptorprovided by RGD
Primary source: RGD:2703
See related: EnsemblRapid:ENSRNOG00000001152 AllianceGenome:RGD:2703
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Glip; RATGL1RCP
Summary: Enables glucagon-like peptide 1 receptor activity and peptide hormone binding activity. Involved in several processes, including cAMP/PKA signal transduction; learning or memory; and positive regulation of insulin secretion. Located in plasma membrane. Used to study hyperglycemia and hypertension. Biomarker of obesity. Human ortholog(s) of this gene implicated in obesity. Orthologous to human GLP1R (glucagon like peptide 1 receptor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 72.1) See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (8973393..9011622)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (8972004..9010241)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (9586075..9626228)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FXR-mediated epigenetic regulation of GLP-1R expression contributes to enhanced incretin effect in diabetes after RYGB.
Title: FXR-mediated epigenetic regulation of GLP-1R expression contributes to enhanced incretin effect in diabetes after RYGB.
Glucagon-like peptide-1 receptor signaling modifies the extent of diabetic kidney disease through dampening the receptor for advanced glycation end products-induced inflammation.
Title: Glucagon-like peptide-1 receptor signaling modifies the extent of diabetic kidney disease through dampening the receptor for advanced glycation end products-induced inflammation.
Glucagon-like peptide-1 receptor regulates receptor of advanced glycation end products in high glucose-treated rat mesangial cells.
Title: Glucagon-like peptide-1 receptor regulates receptor of advanced glycation end products in high glucose-treated rat mesangial cells.
Sleeve Gastrectomy Improves High-Fat Diet-Associated Hepatic Steatosis Independent of the Glucagon-like-Petpide-1 Receptor in Rats.
Title: Sleeve Gastrectomy Improves High-Fat Diet-Associated Hepatic Steatosis Independent of the Glucagon-like-Petpide-1 Receptor in Rats.
Role of Renal Sympathetic Nerves in GLP-1 (Glucagon-Like Peptide-1) Receptor Agonist Exendin-4-Mediated Diuresis and Natriuresis in Diet-Induced Obese Rats.
Title: Role of Renal Sympathetic Nerves in GLP-1 (Glucagon-Like Peptide-1) Receptor Agonist Exendin-4-Mediated Diuresis and Natriuresis in Diet-Induced Obese Rats.
Microglial Activation of GLP-1R Signaling in Neuropathic Pain Promotes Gene Expression Adaption Involved in Inflammatory Responses.
Title: Microglial Activation of GLP-1R Signaling in Neuropathic Pain Promotes Gene Expression Adaption Involved in Inflammatory Responses.
Geniposide Ameliorated Dexamethasone-Induced Cholesterol Accumulation in Osteoblasts by Mediating the GLP-1R/ABCA1 Axis.
Title: Geniposide Ameliorated Dexamethasone-Induced Cholesterol Accumulation in Osteoblasts by Mediating the GLP-1R/ABCA1 Axis.
Distribution and ultrastructural localization of the glucagon-like peptide-1 receptor (GLP-1R) in the rat brain.
Title: Distribution and ultrastructural localization of the glucagon-like peptide-1 receptor (GLP-1R) in the rat brain.
The supramammillary nucleus controls anxiety-like behavior; key role of GLP-1R.
Title: The supramammillary nucleus controls anxiety-like behavior; key role of GLP-1R.
GABA neurons in the nucleus tractus solitarius express GLP-1 receptors and mediate anorectic effects of liraglutide in rats.
Title: GABA neurons in the nucleus tractus solitarius express GLP-1 receptors and mediate anorectic effects of liraglutide in rats.

Submit: New GeneRIF Correction See all GeneRIFs (98)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Glp1r (e-PCR), detects polymorphism
- UniSTS:257077

RH138657 (e-PCR)
- UniSTS:220744

Glp1r (e-PCR), detects polymorphism
- UniSTS:143221

D20Wox7 (e-PCR)
- UniSTS:517818

RH94780 (e-PCR)
- UniSTS:120027

D20Got6 (e-PCR)
- UniSTS:112864

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IPI Inferred from Physical Interaction more info	PubMed
enables G protein-coupled receptor activity	TAS Traceable Author Statement more info	PubMed
enables glucagon receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucagon receptor activity	IEA Inferred from Electronic Annotation more info
enables glucagon-like peptide 1 receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucagon-like peptide 1 receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables glucagon-like peptide 1 receptor activity	ISO Inferred from Sequence Orthology more info
enables glucagon-like peptide 1 receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables peptide hormone binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide hormone binding	IDA Inferred from Direct Assay more info	PubMed
enables peptide receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in associative learning	IDA Inferred from Direct Assay more info	PubMed
involved_in cAMP/PKA signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to glucagon stimulus	IEA Inferred from Electronic Annotation more info
involved_in feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hormone secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in hormone secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within_positive_effect hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in learning or memory	IEA Inferred from Electronic Annotation more info
involved_in learning or memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in learning or memory	ISO Inferred from Sequence Orthology more info
involved_in memory	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of blood pressure	IEA Inferred from Electronic Annotation more info
acts_upstream_of negative regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in neuropeptide signaling pathway	TAS Traceable Author Statement more info	PubMed
NOT involved_in positive regulation of D-glucose import	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of blood pressure	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of blood pressure	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of blood pressure	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-translational protein targeting to membrane, translocation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within post-translational protein targeting to membrane, translocation	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of heart contraction	IEA Inferred from Electronic Annotation more info
involved_in regulation of heart contraction	ISO Inferred from Sequence Orthology more info
involved_in release of sequestered calcium ion into cytosol	IDA Inferred from Direct Assay more info	PubMed
involved_in response to glucose	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to psychosocial stress	IEA Inferred from Electronic Annotation more info
involved_in response to psychosocial stress	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: glucagon-like peptide 1 receptor

Names: GLP-1 receptor; GLP-1-R; GLP-1R; pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012728.2 → NP_036860.2 glucagon-like peptide 1 receptor precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000020

UniProtKB/Swiss-Prot

P32301, Q64073, Q6LD83

UniProtKB/TrEMBL

F1LRH2

Related

ENSRNOP00000001527.5, ENSRNOT00000001527.8

Conserved Domains (2) summary

cd15268
Location:141 → 419

7tmB1_GLP1R; glucagon-like peptide-1 receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

pfam02793
Location:59 → 128

HRM; Hormone receptor domain