Nolc1 nucleolar and coiled-body phosphoprotein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nolc1provided by RGD
Official Full Name: nucleolar and coiled-body phosphoprotein 1provided by RGD
Primary source: RGD:621578
See related: EnsemblRapid:ENSRNOG00000018704 AllianceGenome:RGD:621578
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nopp140
Summary: Enables several functions, including TFIIB-class transcription factor binding activity; snoRNA binding activity; and snoRNP binding activity. Involved in several processes, including box H/ACA sno(s)RNA metabolic process; positive regulation of DNA-templated transcription; and regulation of protein import into nucleus. Located in nucleolus and nucleoplasm. Part of box C/D methylation guide snoRNP complex and box H/ACA snoRNP complex. Orthologous to human NOLC1 (nucleolar and coiled-body phosphoprotein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 126.1), Brain (RPKM 118.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q54

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (254870195..254881070)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (244921275..244932089)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (265829055..265839819)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data show that Nopp140 reversibly associates with snoRNPs in a phosphorylation-dependent manner, but this association has no effect on pseudouridylation of rRNA.
Title: Immunopurified small nucleolar ribonucleoprotein particles pseudouridylate rRNA independently of their association with phosphorylated Nopp140.
inappropriate expression of grn and/or p130 genes in the brains of male and female neonatal rats by perinatal exposure to phthalate/adipate esters may exert permanent effects on the hypothalamus, thereby decreasing sexual behavior after maturation
Title: Effects of perinatal exposure to phthalate/adipate esters on hypothalamic gene expression and sexual behavior in rats.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA859299 (e-PCR)
- UniSTS:261133

RH132553 (e-PCR)
- UniSTS:215836

RH139909 (e-PCR)
- UniSTS:221993

RH142785 (e-PCR)
- UniSTS:232032

RH142304 (e-PCR)
- UniSTS:231551

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables TFIIB-class transcription factor binding	IDA Inferred from Direct Assay more info	PubMed
enables box C/D methylation guide snoRNP complex binding	IDA Inferred from Direct Assay more info	PubMed
enables box C/D sno(s)RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables box H/ACA snoRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables box H/ACA snoRNP complex binding	IDA Inferred from Direct Assay more info	PubMed
enables molecular function inhibitor activity	ISO Inferred from Sequence Orthology more info
enables nuclear localization sequence binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	IEA Inferred from Electronic Annotation more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in box H/ACA sno(s)RNA metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neural crest cell development	IEA Inferred from Electronic Annotation more info
involved_in neural crest cell development	ISO Inferred from Sequence Orthology more info
involved_in neural crest cell development	ISS Inferred from Sequence or Structural Similarity more info
involved_in neural crest formation	IEA Inferred from Electronic Annotation more info
involved_in neural crest formation	ISO Inferred from Sequence Orthology more info
involved_in neural crest formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in nucleolus organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nucleolus organization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of protein import into nucleus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in regulation of translation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Cajal body	IEA Inferred from Electronic Annotation more info
located_in Cajal body	ISO Inferred from Sequence Orthology more info
part_of box C/D methylation guide snoRNP complex	IDA Inferred from Direct Assay more info	PubMed
part_of box H/ACA snoRNP complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nucleolar and coiled-body phosphoprotein 1

Names: 140 kDa nucleolar phosphoprotein; nucleolar 130 kDa protein; nucleolar phosphoprotein 140; nucleolar phosphoprotein p130

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022869.2 → NP_074060.2 nucleolar and coiled-body phosphoprotein 1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

F1LPS3, P41777

UniProtKB/TrEMBL

A0A8L2QDL7

Related

ENSRNOP00000025788.6, ENSRNOT00000025791.7

Conserved Domains (2) summary

PHA03247
Location:147 → 561

PHA03247; large tegument protein UL36; Provisional

pfam05022
Location:629 → 701

SRP40_C; SRP40, C-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

254870195..254881070

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063272817.1 → XP_063128887.1 nucleolar and coiled-body phosphoprotein 1 isoform X2

UniProtKB/TrEMBL

A6JHK9
XM_063272814.1 → XP_063128884.1 nucleolar and coiled-body phosphoprotein 1 isoform X1

UniProtKB/TrEMBL

A6JHK9