Decr1 2,4-dienoyl-CoA reductase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Decr1provided by RGD
Official Full Name: 2,4-dienoyl-CoA reductase 1provided by RGD
Primary source: RGD:70999
See related: EnsemblRapid:ENSRNOG00000008236 AllianceGenome:RGD:70999
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable 2,4-dienoyl-CoA reductase (NADPH) activity; NADPH binding activity; and identical protein binding activity. Predicted to be involved in fatty acid beta-oxidation and positive regulation of cold-induced thermogenesis. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of catalytic complex. Predicted to be active in mitochondrion. Orthologous to human DECR1 (2,4-dienoyl-CoA reductase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 1165.2), Adrenal (RPKM 1029.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q13

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (34208195..34236074, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (29411172..29439054, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (29573893..29601731, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that 2,4-dienoyl-CoA reductase and hydroxymethylglutaryl-CoA synthase (HMGCS2) were upregulated in alcohol-fed rats.
Title: Overexpression of hydroxymethylglutaryl CoA synthase 2 and 2,4-dienoyl-CoA reductase in rat pancreas following chronic alcohol consumption.
Elevated expression of Decr1 impairs ErbB2/Neu-induced mammary tumor development.
Title: Elevated expression of DecR1 impairs ErbB2/Neu-induced mammary tumor development.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 2,4-dienoyl-CoA reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables 2,4-dienoyl-CoA reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info
enables 2,4-dienoyl-CoA reductase (NADPH) activity	ISO Inferred from Sequence Orthology more info
enables 2,4-dienoyl-CoA reductase (NADPH) activity	ISS Inferred from Sequence or Structural Similarity more info
enables 2,4-dienoyl-CoA reductase (NADPH) activity	TAS Traceable Author Statement more info	PubMed
enables NADPH binding	IEA Inferred from Electronic Annotation more info
enables NADPH binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fatty acid beta-oxidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid beta-oxidation	IEA Inferred from Electronic Annotation more info
involved_in fatty acid beta-oxidation	ISO Inferred from Sequence Orthology more info
involved_in fatty acid beta-oxidation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
part_of catalytic complex	IEA Inferred from Electronic Annotation more info
part_of catalytic complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial

Names: 2,4-dienoyl CoA reductase 1, mitochondrial; 2,4-dienoyl-CoA reductase, mitochondrial; 4-enoyl-CoA reductase

NP_476545.2

EC 1.3.1.124

XP_038965094.1

EC 1.3.1.124

XP_063143156.1

EC 1.3.1.124

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_057197.2 → NP_476545.2 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial precursor

See identical proteins and their annotated locations for NP_476545.2

Status: VALIDATED

Source sequence(s)

BC059120, CO385941, JAXUCZ010000005

UniProtKB/Swiss-Prot

Q64591, Q6PCV4

UniProtKB/TrEMBL

A6IIA8, G3V734

Related

ENSRNOP00000011330.3, ENSRNOT00000011330.8

Conserved Domains (2) summary

PRK07677
Location:59 → 303

PRK07677; short chain dehydrogenase; Provisional

cd05369
Location:57 → 303

TER_DECR_SDR_a; Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

34208195..34236074 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039109166.2 → XP_038965094.1 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial isoform X1

Conserved Domains (1) summary

cl21454
Location:57 → 172

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_063287086.1 → XP_063143156.1 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial isoform X2