Tle1 transducin-like enhancer of split 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tle1provided by MGI
Official Full Name: transducin-like enhancer of split 1provided by MGI
Primary source: MGI:MGI:104636
See related: Ensembl:ENSMUSG00000008305 AllianceGenome:MGI:104636
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Grg1; Grg-1; Tle4l; Estm14; C230057C06Rik
Summary: Enables chromatin binding activity and transcription corepressor activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human TLE1 (TLE family member 1, transcriptional corepressor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 8.8), whole brain E14.5 (RPKM 8.8) and 28 other tissues See more
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Genomic context

Location:: 4 C2; 4 36.06 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (72028182..72124575, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (72109945..72200989, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tle1 attenuates hepatic ischemia/reperfusion injury by suppressing NOD2/NF-kappaB signaling.
Title: Tle1 attenuates hepatic ischemia/reperfusion injury by suppressing NOD2/NF-κB signaling.
These findings indicate that Tle corepressors are differentially partitioned to Runx and Tcf/Lef complexes to instruct CD8(+) lineage choice and cooperatively establish CD8(+) T cell identity, respectively.
Title: Tle corepressors are differentially partitioned to instruct CD8(+) T cell lineage choice and identity.
Demethylation of TLE1 promoter region activates the self-expression in diabetic mice intestinal epithelium cells (IECs). Subsequently, TLE1, through the transcriptional suppression on expression of Hes1, contributes to the aberrant differentiation of IECs in DM mice.
Title: Epigenetic modification of TLE1 induce abnormal differentiation in diabetic mice intestinal epithelium.
Data suggest that Tle1 is highly expressed in activated macrophages cultured in vitro; expression of Tle1 is low in resting macrophages and is up-regulated upon macrophage activation (here, stimulated with recombinant human interleukin-4).
Title: Transducin-like enhancer of split-1 is expressed and functional in human macrophages.
Loss of Tle1 not only results in increased phosphorylation and activation of proinflammatory NF-kappaB but also results in decreased Hes1 (hairy and enhancer of split-1), a negative regulator of inflammation in macrophages
Title: Tle1 tumor suppressor negatively regulates inflammation in vivo and modulates NF-κB inflammatory pathway.
TLE1/TLE3-NuRD corepressor complex facilitates Tbx20-dependent transcriptional repression.
Title: A Gro/TLE-NuRD corepressor complex facilitates Tbx20-dependent transcriptional repression.
Data indicate that cAMP activates Notch signaling and increases the expression of recombinant recognition sequence binding protein at the Jkappa site (RBP-J) and transducin-like enhancer of Split (TLE).
Title: Increased cAMP in monocytes augments Notch signaling mechanisms by elevating RBP-J and transducin-like enhancer of Split (TLE).
TLE is important to promote the formation of the p3 domain and subsequent generation of V3 interneurons.
Title: Establishment of motor neuron-V3 interneuron progenitor domain boundary in ventral spinal cord requires Groucho-mediated transcriptional corepression.
Studies suggest that TLE1 and TLE3 might also play roles independent of HESX1 by interacting with other transcription factors like PROP1.
Title: Corepressors TLE1 and TLE3 interact with HESX1 and PROP1.
Inhibition of cortical neuron differentiation by Groucho/TLE1 requires interaction with WRPW, but not Eh1, repressor peptides
Title: Inhibition of cortical neuron differentiation by Groucho/TLE1 requires interaction with WRPW, but not Eh1, repressor peptides.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tle1 (e-PCR), detects polymorphism
- UniSTS:507280

WI-12646 (e-PCR)
- UniSTS:951

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of anoikis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of beta-catenin-TCF complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: transducin-like enhancer protein 1

Names: groucho-related protein 1; transducin-like enhancer of split 1, homolog of Drosophila E(spl); transducin-like enhancer of split 4 (homolog of Drosophila E(spl)) - like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001285529.1 → NP_001272458.1 transducin-like enhancer protein 1 isoform b

See identical proteins and their annotated locations for NP_001272458.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.

Source sequence(s)

AK044642, AL845340, BC057573, BM939470, BX640475

UniProtKB/Swiss-Prot

Q5SQA8, Q62440

UniProtKB/TrEMBL

Q6PFG2

Conserved Domains (3) summary

cd00200
Location:482 → 766

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:486 → 525

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 132

TLE_N; Groucho/TLE N-terminal Q-rich domain
NM_001285530.1 → NP_001272459.1 transducin-like enhancer protein 1 isoform c

See identical proteins and their annotated locations for NP_001272459.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks two alternate exons that result in the loss of an in-frame segment in the 5' coding region, compared to variant 1. The encoded isoform (c, also known as Grg1-LDGP) is shorter than isoform a.

Source sequence(s)

AK044642, AK052961, AK082499, AL845340, BM939470, BX640475

UniProtKB/Swiss-Prot

Q5SQA8, Q62440

Conserved Domains (4) summary

cd00200
Location:409 → 693

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:413 → 452

7WD40; WD40 repeat [structural motif]

pfam09606
Location:251 → 401

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam03920
Location:1 → 124

TLE_N; Groucho/TLE N-terminal Q-rich domain
NM_001285531.1 → NP_001272460.1 transducin-like enhancer protein 1 isoform d

See identical proteins and their annotated locations for NP_001272460.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks several exons in the central and 3' coding regions, but contains an alternate 3' terminal exon, and it thus differs in its 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (d) has a distinct C-terminus and is significantly shorter than isoform a.

Source sequence(s)

AK044642, AK046402

Consensus CDS

CCDS71407.1

UniProtKB/TrEMBL

Q5SQA5

Related

ENSMUSP00000102960.2, ENSMUST00000107337.8

Conserved Domains (1) summary

pfam03920
Location:1 → 133

TLE_N; Groucho/TLE N-terminal Q-rich domain
NM_001285532.1 → NP_001272461.1 transducin-like enhancer protein 1 isoform e

See identical proteins and their annotated locations for NP_001272461.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks several exons in the central and 3' coding regions, but contains an alternate 3' terminal exon, and it thus differs in its 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (e, also known as Grg1-S) has a distinct C-terminus and is significantly shorter than isoform a.

Source sequence(s)

AK044642, AK046402, AY155196

UniProtKB/TrEMBL

Q5SQA5

Conserved Domains (1) summary

pfam03920
Location:9 → 132

TLE_N; Groucho/TLE N-terminal Q-rich domain
NM_011599.5 → NP_035729.3 transducin-like enhancer protein 1 isoform a

See identical proteins and their annotated locations for NP_035729.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a, also known as Grg1-L).

Source sequence(s)

AK044642, AK048515, AK082499, AL845340, BM939470, BX640475

Consensus CDS

CCDS18274.1

UniProtKB/Swiss-Prot

Q5SQA8, Q62440

UniProtKB/TrEMBL

Q5SQA2

Related

ENSMUSP00000072481.7, ENSMUST00000072695.13

Conserved Domains (3) summary

cd00200
Location:483 → 767

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:487 → 526

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 133

TLE_N; Groucho/TLE N-terminal Q-rich domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

72028182..72124575 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036163960.1 → XP_036019853.1 transducin-like enhancer protein 1 isoform X29

UniProtKB/Swiss-Prot

Q5SQA8, Q62440

Conserved Domains (3) summary

cd00200
Location:362 → 646

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:366 → 405

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 79

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_006537766.5 → XP_006537829.1 transducin-like enhancer protein 1 isoform X28

UniProtKB/Swiss-Prot

Q5SQA8, Q62440

Conserved Domains (4) summary

cd00200
Location:363 → 647

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:367 → 406

7WD40; WD40 repeat [structural motif]

pfam09606
Location:205 → 355

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam03920
Location:1 → 79

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_030253398.2 → XP_030109258.1 transducin-like enhancer protein 1 isoform X18

UniProtKB/Swiss-Prot

Q5SQA8, Q62440

Conserved Domains (3) summary

cd00200
Location:471 → 755

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:475 → 514

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 77

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_030253403.2 → XP_030109263.1 transducin-like enhancer protein 1 isoform X31

Conserved Domains (3) summary

sd00039
Location:164 → 203

7WD40; WD40 repeat [structural motif]

pfam09606
Location:2 → 152

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cl29593
Location:160 → 444

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_030253402.2 → XP_030109262.1 transducin-like enhancer protein 1 isoform X25

UniProtKB/Swiss-Prot

Q5SQA8, Q62440

Conserved Domains (3) summary

cd00200
Location:408 → 692

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:412 → 451

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 124

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_030253399.2 → XP_030109259.1 transducin-like enhancer protein 1 isoform X21

UniProtKB/Swiss-Prot

Q5SQA8, Q62440

Conserved Domains (3) summary

cd00200
Location:443 → 727

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:447 → 486

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 124

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_011249986.4 → XP_011248288.1 transducin-like enhancer protein 1 isoform X32

UniProtKB/Swiss-Prot

Q5SQA8, Q62440

Conserved Domains (3) summary

cd00200
Location:481 → 765

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:485 → 524

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 132

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_017320108.3 → XP_017175597.1 transducin-like enhancer protein 1 isoform X8

UniProtKB/Swiss-Prot

Q5SQA8, Q62440

Conserved Domains (3) summary

cd00200
Location:516 → 800

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:520 → 559

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 132

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_006537761.4 → XP_006537824.1 transducin-like enhancer protein 1 isoform X15

See identical proteins and their annotated locations for XP_006537824.1

UniProtKB/Swiss-Prot

Q5SQA8, Q62440

Conserved Domains (3) summary

cd00200
Location:482 → 766

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:486 → 525

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 133

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_017320107.3 → XP_017175596.1 transducin-like enhancer protein 1 isoform X7

UniProtKB/Swiss-Prot

Q5SQA8, Q62440

Conserved Domains (3) summary

cd00200
Location:517 → 801

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:521 → 560

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 133

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_030253400.2 → XP_030109260.1 transducin-like enhancer protein 1 isoform X22

UniProtKB/Swiss-Prot

Q5SQA8, Q62440

Conserved Domains (4) summary

cd00200
Location:419 → 703

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:423 → 462

7WD40; WD40 repeat [structural motif]

pfam09606
Location:261 → 411

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam03920
Location:1 → 125

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_036163956.1 → XP_036019849.1 transducin-like enhancer protein 1 isoform X4

UniProtKB/Swiss-Prot

Q5SQA8, Q62440

Conserved Domains (3) summary

cd00200
Location:526 → 810

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:530 → 569

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 142

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_006537759.4 → XP_006537822.1 transducin-like enhancer protein 1 isoform X12

See identical proteins and their annotated locations for XP_006537822.1

UniProtKB/Swiss-Prot

Q5SQA8, Q62440

Conserved Domains (3) summary

cd00200
Location:492 → 776

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:496 → 535

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 143

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_006537758.4 → XP_006537821.1 transducin-like enhancer protein 1 isoform X11

UniProtKB/Swiss-Prot

Q5SQA8, Q62440

UniProtKB/TrEMBL

Q5SQA3

Related

ENSMUSP00000030095.5, ENSMUST00000030095.11

Conserved Domains (3) summary

cd00200
Location:493 → 777

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:497 → 536

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 143

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_017320105.3 → XP_017175594.1 transducin-like enhancer protein 1 isoform X3

UniProtKB/Swiss-Prot

Q5SQA8, Q62440

Conserved Domains (3) summary

cd00200
Location:527 → 811

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:531 → 570

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 143

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_036163959.1 → XP_036019852.1 transducin-like enhancer protein 1 isoform X27

UniProtKB/Swiss-Prot

Q5SQA8, Q62440

Conserved Domains (4) summary

PHA03378
Location:193 → 355

PHA03378; EBNA-3B; Provisional

cd00200
Location:371 → 655

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:375 → 414

7WD40; WD40 repeat [structural motif]

pfam03920
Location:17 → 87

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_011249985.4 → XP_011248287.2 transducin-like enhancer protein 1 isoform X26

UniProtKB/Swiss-Prot

Q5SQA8, Q62440

Conserved Domains (3) summary

cd00200
Location:405 → 689

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:409 → 448

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 87

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_017320109.3 → XP_017175598.1 transducin-like enhancer protein 1 isoform X16

UniProtKB/Swiss-Prot

Q5SQA8, Q62440

Conserved Domains (3) summary

cd00200
Location:479 → 763

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:483 → 522

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 85

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_036163958.1 → XP_036019851.1 transducin-like enhancer protein 1 isoform X24

UniProtKB/Swiss-Prot

Q5SQA8, Q62440

Conserved Domains (3) summary

cd00200
Location:416 → 700

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:420 → 459

7WD40; WD40 repeat [structural motif]

pfam03920
Location:17 → 136

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_030253401.2 → XP_030109261.1 transducin-like enhancer protein 1 isoform X23

UniProtKB/Swiss-Prot

Q5SQA8, Q62440

Conserved Domains (4) summary

cd00200
Location:417 → 701

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:421 → 460

7WD40; WD40 repeat [structural motif]

pfam09606
Location:259 → 409

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam03920
Location:1 → 132

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_017320112.3 → XP_017175601.1 transducin-like enhancer protein 1 isoform X20

UniProtKB/Swiss-Prot

Q5SQA8, Q62440

Conserved Domains (3) summary

cd00200
Location:451 → 735

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:455 → 494

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 132

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_011249982.4 → XP_011248284.2 transducin-like enhancer protein 1 isoform X6

UniProtKB/Swiss-Prot

Q5SQA8, Q62440

Conserved Domains (3) summary

cd00200
Location:524 → 808

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:528 → 567

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 140

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_011249981.4 → XP_011248283.1 transducin-like enhancer protein 1 isoform X13

UniProtKB/Swiss-Prot

Q5SQA8, Q62440

Conserved Domains (3) summary

cd00200
Location:491 → 775

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:495 → 534

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 141

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_017320106.3 → XP_017175595.1 transducin-like enhancer protein 1 isoform X5

UniProtKB/Swiss-Prot

Q5SQA8, Q62440

Conserved Domains (3) summary

cd00200
Location:525 → 809

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:529 → 568

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 141

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_017320111.3 → XP_017175600.1 transducin-like enhancer protein 1 isoform X19

UniProtKB/Swiss-Prot

Q5SQA8, Q62440

Conserved Domains (3) summary

cd00200
Location:461 → 745

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:465 → 504

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 133

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_011249979.4 → XP_011248281.2 transducin-like enhancer protein 1 isoform X2

UniProtKB/Swiss-Prot

Q5SQA8, Q62440

Conserved Domains (3) summary

cd00200
Location:534 → 818

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:538 → 577

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 150

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_011249980.4 → XP_011248282.1 transducin-like enhancer protein 1 isoform X10

UniProtKB/Swiss-Prot

Q5SQA8, Q62440

Conserved Domains (3) summary

cd00200
Location:500 → 784

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:504 → 543

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 151

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_011249978.4 → XP_011248280.1 transducin-like enhancer protein 1 isoform X9

UniProtKB/Swiss-Prot

Q5SQA8, Q62440

Conserved Domains (3) summary

cd00200
Location:501 → 785

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:505 → 544

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 151

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_017320104.3 → XP_017175593.1 transducin-like enhancer protein 1 isoform X1

UniProtKB/Swiss-Prot

Q5SQA8, Q62440

Conserved Domains (3) summary

cd00200
Location:535 → 819

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:539 → 578

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 151

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_006537760.4 → XP_006537823.1 transducin-like enhancer protein 1 isoform X14

UniProtKB/Swiss-Prot

Q5SQA8, Q62440

UniProtKB/TrEMBL

Q5SQA4

Related

ENSMUSP00000099912.3, ENSMUST00000102848.9

Conserved Domains (3) summary

cd00200
Location:490 → 774

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:494 → 533

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 141

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_017320110.3 → XP_017175599.1 transducin-like enhancer protein 1 isoform X17

UniProtKB/Swiss-Prot

Q5SQA8, Q62440

Related

ENSMUST00000132550.8

Conserved Domains (3) summary

cd00200
Location:471 → 755

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:475 → 514

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 87

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_036163961.1 → XP_036019854.1 transducin-like enhancer protein 1 isoform X30

Conserved Domains (4) summary

PHA03378
Location:129 → 291

PHA03378; EBNA-3B; Provisional

cd00200
Location:307 → 591

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:311 → 350

7WD40; WD40 repeat [structural motif]

pfam03920
Location:1 → 23

TLE_N; Groucho/TLE N-terminal Q-rich domain