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    IDH2 isocitrate dehydrogenase subunit 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816218, updated on 18-Sep-2024

    Summary

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    Official Symbol
    IDH2
    Official Full Name
    isocitrate dehydrogenase subunit 2
    Primary source
    TAIR:AT2G17130
    Locus tag
    AT2G17130
    See related
    Araport:AT2G17130
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F6P23.14; F6P23_14; IDH-II; isocitrate dehydrogenase II; isocitrate dehydrogenase subunit 2; NAD+ DEPENDENT ISOCITRATE DEHYDROGENASE SUBUNIT 2
    Summary
    Encodes a regulatory subunit of the mitochondrially-localized NAD+- dependent isocitrate dehydrogenase.
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    Genomic context

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    See IDH2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    4
    Sequence:
    Chromosome: 2; NC_003071.7 (7460814..7462607, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene DNA-directed RNA polymerase subunit beta, putative (DUF630 and DUF632) Neighboring gene pseudo Neighboring gene lysm domain GPI-anchored protein 2 precursor Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene Plant regulator RWP-RK family protein Neighboring gene Interleukin-1 receptor-associated kinase 4 protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NAD-dependent isocitrate dehydrogenase mutants of Arabidopsis suggest the enzyme is not limiting for nitrogen assimilation. Lemaitre T, et al. Plant Physiol, 2007 Jul. PMID 17468208, Free PMC Article
    2. The Extra-Pathway Interactome of the TCA Cycle: Expected and Unexpected Metabolic Interactions. Zhang Y, et al. Plant Physiol, 2018 Jul. PMID 29794018, Free PMC Article
    3. Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins. Heazlewood JL, et al. Plant Cell, 2004 Jan. PMID 14671022, Free PMC Article
    4. Advanced proteomic analyses yield a deep catalog of ubiquitylation targets in Arabidopsis. Kim DY, et al. Plant Cell, 2013 May. PMID 23667124, Free PMC Article
    5. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Leaf IDH activity reduced by 43% in mutant
      Title: NAD-dependent isocitrate dehydrogenase mutants of Arabidopsis suggest the enzyme is not limiting for nitrogen assimilation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_127267.3
    NM_179632.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables isocitrate dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to isocitrate dehydrogenase (NAD+) activity IMP
    Inferred from Mutant Phenotype
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within isocitrate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		  
    acts_upstream_of_or_within tricarboxylic acid cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    isocitrate dehydrogenase subunit 2
    NP_179304.1
    • isocitrate dehydrogenase subunit 2 (IDH2); FUNCTIONS IN: isocitrate dehydrogenase (NAD+) activity; INVOLVED IN: isocitrate metabolic process, tricarboxylic acid cycle, metabolic process; LOCATED IN: mitochondrion; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Isocitrate/isopropylmalate dehydrogenase (InterPro:IPR001804), Isocitrate dehydrogenase NAD-dependent, mitochondrial (InterPro:IPR004434); BEST Arabidopsis thaliana protein match is: isocitrate dehydrogenase 1 (TAIR:AT4G35260.1); Has 16085 Blast hits to 15952 proteins in 2729 species: Archae - 398; Bacteria - 9705; Metazoa - 617; Fungi - 814; Plants - 241; Viruses - 0; Other Eukaryotes - 4310 (source: NCBI BLink).
    NP_849963.1
    • isocitrate dehydrogenase subunit 2 (IDH2); FUNCTIONS IN: isocitrate dehydrogenase (NAD+) activity; INVOLVED IN: isocitrate metabolic process, tricarboxylic acid cycle, metabolic process; LOCATED IN: mitochondrion; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Isocitrate/isopropylmalate dehydrogenase (InterPro:IPR001804), Isocitrate dehydrogenase NAD-dependent, mitochondrial (InterPro:IPR004434); BEST Arabidopsis thaliana protein match is: isocitrate dehydrogenase 1 (TAIR:AT4G35260.1); Has 15958 Blast hits to 15829 proteins in 2704 species: Archae - 398; Bacteria - 9603; Metazoa - 617; Fungi - 818; Plants - 241; Viruses - 0; Other Eukaryotes - 4281 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      7460814..7462607 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_179632.2 → NP_849963.1  isocitrate dehydrogenase subunit 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849963.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VYB0
      Conserved Domains (1) summary
      PLN00123
      Location:8 → 363
      PLN00123; isocitrate dehydrogenase (NAD+)

    2. NM_127267.3 → NP_179304.1  isocitrate dehydrogenase subunit 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_179304.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P93032, Q7XJT6
      UniProtKB/TrEMBL
      A0A178W0H4, A0A5S9WYL6
      Conserved Domains (1) summary
      PLN00123
      Location:8 → 367
      PLN00123; isocitrate dehydrogenase (NAD+)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P93032.2

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