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    DRP3A dynamin-related protein 3A [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829506, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DRP3A
    Official Full Name
    dynamin-related protein 3A
    Primary source
    TAIR:AT4G33650
    Locus tag
    AT4G33650
    See related
    Araport:AT4G33650
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ABERRANT PEROXISOME MORPHOLOGY 1; ADL2; ADL2A; APEM1; ARABIDOPSIS DYNAMIN-LIKE 2; dynamin-related protein 3A; non responding to oxylipins 15; NOXY15; T16L1.140; T16L1_140
    Summary
    Encodes a protein with high sequence similarity to the dynamin superfamily. Among those members ADL2 was most closely related to Dnm1p of yeast and likely a member of the Vps1p subfamily. Widely expressed in various tissues with highest expression in flower tissues. Localizes to the chloroplast, mitochondrion and peroxisome. Involved in peroxisome and mitochondria fission in combination with DRP3B.
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    Genomic context

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    See DRP3A in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    20
    Sequence:
    Chromosome: 4; NC_003075.7 (16160824..16166994)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene UvrB/UvrC domain protein (DUF3506) Neighboring gene ncRNA Neighboring gene costars family protein Neighboring gene ncRNA Neighboring gene cysteine-rich TM module stress tolerance protein Neighboring gene uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of an Arabidopsis cDNA encoding a dynamin-like protein that is localized to plastids. Kang SG, et al. Plant Mol Biol, 1998 Oct. PMID 9747851
    2. ADL2a, like ADL2b, is involved in the control of higher plant mitochondrial morphology. Logan DC, et al. J Exp Bot, 2004 Mar. PMID 14754924
    3. Arabidopsis dynamin-like 2 that binds specifically to phosphatidylinositol 4-phosphate assembles into a high-molecular weight complex in vivo and in vitro. Kim YW, et al. Plant Physiol, 2001 Nov. PMID 11706203, Free PMC Article
    4. Phosphorylation and ubiquitination of dynamin-related proteins (AtDRP3A/3B) synergically regulate mitochondrial proliferation during mitosis. Wang F, et al. Plant J, 2012 Oct. PMID 22595081
    5. A defect of peroxisomal membrane protein 38 causes enlargement of peroxisomes. Mano S, et al. Plant Cell Physiol, 2011 Dec. PMID 22034551

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Post-translational modifications of DRP3A/3B in BY-2 suspension cells regulate the morphological dynamics of mitochondria during mitosis.
      Title: Phosphorylation and ubiquitination of dynamin-related proteins (AtDRP3A/3B) synergically regulate mitochondrial proliferation during mitosis.
    2. The roles of DRP3A, DRP3B, and DRP5B in organelle division and plant development, were investigated.
      Title: Differential roles of Arabidopsis dynamin-related proteins DRP3A, DRP3B, and DRP5B in organelle division.
    3. Studies indicated that the noxy15 mutation was located in At4g33650, encoding the dynamin-related protein DRP3A.
      Title: Defense activated by 9-lipoxygenase-derived oxylipins requires specific mitochondrial proteins.
    4. DRP3B and DRP3A have redundant molecular functions in mitochondrial fission, whereas DRP3B has a minor role in peroxisomal fission that is distinct from that of DRP3A.
      Title: Arabidopsis dynamin-related proteins DRP3A and DRP3B are functionally redundant in mitochondrial fission, but have distinct roles in peroxisomal fission.
    5. Data support a model for the replication of preexisting peroxisomes wherein DRP3A stimulates fission of elongated peroxisomes into daughter peroxisomes, which are then distributed between daughter cells. [DRP3A]
      Title: Arabidopsis PEROXIN11c-e, FISSION1b, and DYNAMIN-RELATED PROTEIN3A cooperate in cell cycle-associated replication of peroxisomes.
    6. This study uses a T-DNA knockout to confirm the role of ADL2a/DRP3A in the regulation of plant mitochondrial morphology.
      Title: ADL2a, like ADL2b, is involved in the control of higher plant mitochondrial morphology.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_119521.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables phosphatidylinositol binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within chloroplast organization NAS
    Non-traceable Author Statement
    more info
    		  
    acts_upstream_of_or_within mitochondrial fission IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within peroxisome fission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within post-embryonic development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of peroxisome size IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    dynamin-related protein 3A
    NP_001190906.1
    • dynamin-related protein 3A (DRP3A); CONTAINS InterPro DOMAIN/s: Dynamin GTPase effector (InterPro:IPR003130), GTPase effector domain, GED (InterPro:IPR020850), Dynamin, GTPase region, conserved site (InterPro:IPR019762), Dynamin, GTPase domain (InterPro:IPR001401), Dynamin central region (InterPro:IPR000375); BEST Arabidopsis thaliana protein match is: dynamin related protein (TAIR:AT2G14120.1).
    NP_567931.1
    • dynamin-related protein 3A (DRP3A); FUNCTIONS IN: phosphoinositide binding, GTP binding, GTPase activity; INVOLVED IN: post-embryonic development, chloroplast organization, peroxisome fission, mitochondrial fission; LOCATED IN: in 6 components; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Dynamin GTPase effector (InterPro:IPR003130), GTPase effector domain, GED (InterPro:IPR020850), Dynamin, GTPase region, conserved site (InterPro:IPR019762), Dynamin, GTPase domain (InterPro:IPR001401), Dynamin central region (InterPro:IPR000375); BEST Arabidopsis thaliana protein match is: dynamin related protein (TAIR:AT2G14120.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      16160824..16166994
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001203977.2 → NP_001190906.1  dynamin-related protein 3A [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190906.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UUQ6, A0A654FV82, F4JJ15
      Conserved Domains (3) summary
      cd08771
      Location:57 → 330
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      pfam01031
      Location:252 → 537
      Dynamin_M; Dynamin central region
      pfam02212
      Location:670 → 757
      GED; Dynamin GTPase effector domain

    2. NM_119521.5 → NP_567931.1  dynamin-related protein 3A [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567931.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22403, O81882, Q8S944, Q94CF3
      UniProtKB/TrEMBL
      A0A178UWS8, A0A5S9XYB2, A0A654FV82
      Conserved Domains (3) summary
      cd08771
      Location:57 → 330
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      pfam01031
      Location:252 → 537
      Dynamin_M; Dynamin central region
      pfam02212
      Location:669 → 756
      GED; Dynamin GTPase effector domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8S944.2

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