Rdh7 retinol dehydrogenase 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rdh7provided by RGD
Official Full Name: retinol dehydrogenase 7provided by RGD
Primary source: RGD:631370
See related: EnsemblRapid:ENSRNOG00000004391 AllianceGenome:RGD:631370
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rdh3; RoDH(III); RGD1307178
Summary: Predicted to enable all-trans-retinol dehydrogenase (NAD+) activity. Predicted to be involved in retinol metabolic process and steroid metabolic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to human RDH16 (retinol dehydrogenase 16). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 3000.8) See more
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Genomic context

Location:: 7q22

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (65561259..65574618, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (63676016..63689375, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (71125358..71164014, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AU044268 (e-PCR)
- UniSTS:160318

RH134392 (e-PCR)
- UniSTS:217674

D7Rat75 (e-PCR), detects polymorphism
- UniSTS:228192

BE106097 (e-PCR)
- UniSTS:246134

RH144391 (e-PCR)
- UniSTS:233636

d7rat45 (e-PCR)
- UniSTS:120523

RH136995 (e-PCR)
- UniSTS:219084

RH130952 (e-PCR)
- UniSTS:214236

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables all-trans-retinol dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in retinol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in retinol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in steroid metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: retinol dehydrogenase 7

Names: RODH I; RODH III; hypothetical gene supported by NM_133543; retinol dehydrogenase 3; retinol dehydrogenase type III

NP_598227.3

EC 1.1.1.105

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133543.3 → NP_598227.3 retinol dehydrogenase 7

See identical proteins and their annotated locations for NP_598227.3

Status: PROVISIONAL

Source sequence(s)

BC088090

UniProtKB/Swiss-Prot

P50169, P55006, Q4KMB6

UniProtKB/TrEMBL

A0A0U1RVK8, A6HQX7

Related

ENSRNOP00000005875.7, ENSRNOT00000005875.9

Conserved Domains (2) summary

cd09805
Location:30 → 306

type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs

pfam00106
Location:30 → 214

adh_short; short chain dehydrogenase