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    Dcun1d1 defective in cullin neddylation 1 domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310324, updated on 27-Nov-2024

    Summary

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    Symbol
    Dcun1d1provided by RGD
    Full Name
    defective in cullin neddylation 1 domain containing 1provided by RGD
    Primary source
    RGD:1309668
    See related
    EnsemblRapid:ENSRNOG00000012734 AllianceGenome:RGD:1309668
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tes3
    Summary
    Predicted to enable cullin family protein binding activity; ubiquitin conjugating enzyme binding activity; and ubiquitin-like protein binding activity. Predicted to be involved in positive regulation of protein neddylation; protein neddylation; and regulation of protein ubiquitination. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of ubiquitin ligase complex. Orthologous to human DCUN1D1 (defective in cullin neddylation 1 domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 184.6), Spleen (RPKM 133.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dcun1d1 in Genome Data Viewer
    Location:
    2q25
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (120649445..120700879, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (118721275..118772606, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (122476173..122527153, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 1158 Neighboring gene ATPase phospholipid transporting 11B (putative) Neighboring gene uncharacterized LOC134485899 Neighboring gene methylcrotonyl-CoA carboxylase subunit 1 Neighboring gene coiled-coil domain containing 144B Neighboring gene small ribosomal subunit protein uS13-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation. Kim AY, et al. J Biol Chem, 2008 Nov 28. PMID 18826954, Free PMC Article
    2. Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase. Scott DC, et al. Nat Chem Biol, 2017 Aug. PMID 28581483, Free PMC Article
    3. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cullin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cullin family protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-like protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of protein neddylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein neddylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein neddylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DCN1-like protein 1
    Names
    DCN1, defective in cullin neddylation 1, domain containing 1
    DCN1-like protein 1-like
    testis derived transcript 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395100.1 → NP_001382029.1  DCN1-like protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A0G2K8D6, A0A8I6AI94
      Related
      ENSRNOP00000092738.1, ENSRNOT00000111905.2
      Conserved Domains (1) summary
      cl21463
      Location:1 → 51
      UBA_like_SF; UBA domain-like superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      120649445..120700879 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006232261.5 → XP_006232323.1  DCN1-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006232323.1

      UniProtKB/TrEMBL
      A0A8I5ZYZ4, A0A8I6ADB9
      Related
      ENSRNOP00000090810.1, ENSRNOT00000109045.2
      Conserved Domains (2) summary
      pfam03556
      Location:150 → 261
      Cullin_binding; Cullin binding
      cl21463
      Location:15 → 65
      UBA_like_SF; UBA domain-like superfamily

    2. XM_063281774.1 → XP_063137844.1  DCN1-like protein 1 isoform X3

    3. XM_006232262.5 → XP_006232324.1  DCN1-like protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K8D6, A0A8I5Y621
      Related
      ENSRNOP00000076537.1, ENSRNOT00000104963.2
      Conserved Domains (2) summary
      pfam03556
      Location:141 → 252
      Cullin_binding; Cullin binding
      cl21463
      Location:6 → 56
      UBA_like_SF; UBA domain-like superfamily

    4. XM_063281773.1 → XP_063137843.1  DCN1-like protein 1 isoform X3

    5. XM_039102240.2 → XP_038958168.1  DCN1-like protein 1 isoform X4

      UniProtKB/TrEMBL
      A6IHV8
      Conserved Domains (2) summary
      pfam03556
      Location:150 → 189
      Cullin_binding; Cullin binding
      cl21463
      Location:15 → 65
      UBA_like_SF; UBA domain-like superfamily

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107668.1: Suppressed sequence

      Description
      NM_001107668.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein Strain
    Heading Accession and Version

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