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    SRC SRC proto-oncogene, non-receptor tyrosine kinase [ Homo sapiens (human) ]

    Gene ID: 6714, updated on 4-Jan-2025

    Summary

    Official Symbol
    SRCprovided by HGNC
    Official Full Name
    SRC proto-oncogene, non-receptor tyrosine kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:11283
    See related
    Ensembl:ENSG00000197122 MIM:190090; AllianceGenome:HGNC:11283
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ASV; SRC1; THC6; c-SRC; p60-Src
    Summary
    This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in stomach (RPKM 19.0), testis (RPKM 19.0) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SRC in Genome Data Viewer
    Location:
    20q11.23
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (37344699..37406050)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (39068774..39130114)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (35973102..36034453)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:35918028-35918932 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17834 Neighboring gene mannosidase beta like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:35943167-35944074 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:35944075-35944984 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:35947577-35948274 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:35964723-35965222 Neighboring gene uncharacterized LOC105372606 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:35968539-35969071 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17836 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17837 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12889 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:35975052-35975552 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17838 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17839 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:35987177-35987747 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17840 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17841 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17842 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17843 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17844 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12891 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:36019051-36019552 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:36022575-36023431 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:36023432-36024287 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:36024288-36025144 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:36025145-36026001 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:36026002-36026858 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12892 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:36035731-36036650 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:36040408-36040917 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:36040918-36041426 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:36049663-36050276 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:36054060-36054560 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:36054561-36055061 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:36070038-36070538 Neighboring gene ribosomal protein L7a pseudogene 14 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:36114871-36115516 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:36115517-36116161 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17845 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:36146997-36147860 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:36147861-36148724 Neighboring gene BLCAP apoptosis inducing factor Neighboring gene neuronatin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (33 hits/1317 screens)

    Associated conditions

    Description Tests
    Colorectal cancer
    MedGen: C0346629 OMIM: 114500 GeneReviews: Lynch Syndrome
    not available
    Thrombocytopenia 6
    MedGen: C4310789 OMIM: 616937 GeneReviews: Not available
    not available

    EBI GWAS Catalog

    Description
    Genome-wide association study of retinopathy in individuals without diabetes.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 activates SRC in monocyte derived dendritic cells PubMed
    Knockdown of c-SRC tyrosine kinase by siRNA enhances HIV-1 infectivity in Jurkat cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env SLIT2N, an active fragment of SLIT2, inhibits M-tropic HIV-1 gp120-induced Src signaling and activation of its downstream targets Pyk2, CDC42, Rac1, and paxillin in immature monocyte-derived dendritic cells PubMed
    env Interaction of SLIT2 with Robo4 significantly inhibits HIV-1 gp120-induced phosphorylation of c-Src in human lymphatic endothelial cells PubMed
    Nef nef Activation and translocation of Src kinase is critical for Nef-mediated CD80 and CD86 internalization PubMed
    nef HIV-1 Nef-mediated downregulation of MHC-I requires Nef motif EEEE(65)-dependent binding to the sorting protein PACS-2, which targets Nef to the paranuclear region and enables Nef PXXP(75) to bind and activate a trans-Golgi network localized Src kinase PubMed
    nef High throughput screening identifies compounds targeting the Nef SH3 binding surface and that efficiently compete for Nef-SH3 interactions PubMed
    nef HIV-1 Nef increases expression of both VEGF and its transcriptional regulator, hypoxia-inducible factor 2alpha (HIF-2alpha), in a Src kinase-and Stat3-dependent manner PubMed
    nef The RT loop region (residues 90-108) in the Src SH3 domain binds to HIV-1 Nef, but this binding is looser than that of the Hck SH3 domain to HIV-1 Nef PubMed
    Tat tat HIV-1 Tat increases permeability of human glomerular endothelial cells by activating Rho-A, pMLC, and c-Src pathways, which involves VEGF-A or FGF-2. PubMed
    tat HIV-1 Tat stimulates the tyrosine phosphorylation and activation of c-Src kinase resulting in the activation of the intrinsic kinase activity of c-Src, an effect associated with Tat-induced angiogenesis and Kaposi's sarcoma PubMed
    tat HIV-1 Tat and cocaine treatment upregulates the expreesion of phophorylated SRC protein in human pulmonary arterial smooth muscle cells PubMed
    tat HIV-1 Tat potentiates NMDA-evoked (Ca2+)I responses involve LRP and a Src family kinase via the NOS/sGC/PKG pathway PubMed
    tat Endothelial cell adherent to HIV-1 Tat induces upregulation of VEGFR2, integrin beta(3) subunit, pp60src and recruits VEGFR2, integrin beta(3) subunit, paxillin, focal adhesion kinase, and pp60src to ventral plasma membranes PubMed
    tat Adhesion of endothelial cells to HIV-1 Tat triggers a signal transduction pathway, which leads to phosphorylation of VEGFR2 and pp60src and activation of ERK1/2 PubMed
    tat HIV-1 Tat inhibits autophagy in bystander macrophages/monocytic cells through Tat-mediated activation and phosphorylation of Src-Akt signaling PubMed
    tat HIV-1 Tat treatment of human neurons results in tyrosine (Y) phosphorylation at position 1325 of the NMDAR subunit 2A (NR2A) in a src kinase-dependent manner PubMed
    tat HIV-1 Tat exerts several pleiotropic effects by interacting with different cellular receptors, including integrin alpha(v)beta3, which triggers the activation of focal adhesion kinase, RhoA and pp60src PubMed
    reverse transcriptase gag-pol Knockdown of c-Src or Pyk2 by siRNA followed by HIV-1 infection in Jurkat T-cells leads to increased reverse transcriptase activity, viral cDNA, and integrated viral genome, suggesting that c-Src and PYK2 interact with HIV-1 RT PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Items 1 - 25 of 35
    Function Evidence Code Pubs
    enables ATP binding  
    enables ATPase binding  
    enables BMP receptor binding PubMed 
    enables SH2 domain binding PubMed 
    enables cadherin binding PubMed 
    enables connexin binding  
    enables enzyme binding PubMed 
    enables ephrin receptor binding PubMed 
    enables heme binding PubMed 
    enables histone H2AXY142 kinase activity  
    enables histone H3Y41 kinase activity  
    enables insulin receptor binding  
    enables integrin binding PubMed 
    enables integrin binding PubMed 
    enables non-membrane spanning protein tyrosine kinase activity  
    enables non-membrane spanning protein tyrosine kinase activity PubMed 
    enables non-membrane spanning protein tyrosine kinase activity PubMed 
    enables non-membrane spanning protein tyrosine kinase activity PubMed 
    enables nuclear estrogen receptor binding  
    enables phospholipase activator activity PubMed 
    enables phospholipase binding PubMed 
    enables phosphoprotein binding PubMed 
    enables protein binding PubMed 
    enables protein kinase C binding  
    enables protein kinase activity PubMed 
    enables protein tyrosine kinase activator activity PubMed 
    enables protein tyrosine kinase activity PubMed 
    enables protein tyrosine kinase activity PubMed 
    enables protein tyrosine kinase activity PubMed 
    enables protein tyrosine kinase activity PubMed 
    enables protein tyrosine kinase activity  
    enables scaffold protein binding PubMed 
    enables signaling receptor binding  
    enables signaling receptor binding PubMed 
    enables transmembrane transporter binding PubMed 
    Items 1 - 25 of 35
    Items 1 - 25 of 123
    Process Evidence Code Pubs
    involved_in DNA biosynthetic process  
    involved_in ERBB2 signaling pathway  
    involved_in Fc-gamma receptor signaling pathway involved in phagocytosis  
    involved_in T cell costimulation  
    involved_in adherens junction organization  
    involved_in angiotensin-activated signaling pathway  
    involved_in bone resorption  
    involved_in branching involved in mammary gland duct morphogenesis  
    involved_in cell adhesion  
    involved_in cell differentiation  
    involved_in cell-cell adhesion  
    involved_in cellular response to fatty acid  
    involved_in cellular response to fluid shear stress  
    involved_in cellular response to hydrogen peroxide  
    involved_in cellular response to hypoxia  
    involved_in cellular response to insulin stimulus  
    involved_in cellular response to lipopolysaccharide  
    involved_in cellular response to peptide hormone stimulus  
    involved_in cellular response to platelet-derived growth factor stimulus  
    involved_in cellular response to progesterone stimulus  
    involved_in cellular response to prolactin  
    involved_in cellular response to reactive oxygen species PubMed 
    involved_in chromatin remodeling  
    involved_in ephrin receptor signaling pathway  
    involved_in epidermal growth factor receptor signaling pathway  
    involved_in epidermal growth factor receptor signaling pathway  
    involved_in focal adhesion assembly PubMed 
    involved_in forebrain development  
    involved_in integrin-mediated signaling pathway PubMed 
    involved_in interleukin-6-mediated signaling pathway PubMed 
    involved_in intestinal epithelial cell development PubMed 
    involved_in intracellular signal transduction PubMed 
    involved_in learning or memory  
    involved_in leukocyte migration  
    involved_in macroautophagy  
    involved_in myoblast proliferation  
    involved_in negative regulation of anoikis PubMed 
    involved_in negative regulation of apoptotic process PubMed 
    involved_in negative regulation of cysteine-type endopeptidase activity PubMed 
    involved_in negative regulation of extrinsic apoptotic signaling pathway  
    involved_in negative regulation of extrinsic apoptotic signaling pathway PubMed 
    involved_in negative regulation of focal adhesion assembly  
    involved_in negative regulation of gene expression  
    involved_in negative regulation of hippo signaling PubMed 
    involved_in negative regulation of inflammatory response to antigenic stimulus  
    involved_in negative regulation of intrinsic apoptotic signaling pathway  
    involved_in negative regulation of intrinsic apoptotic signaling pathway PubMed 
    involved_in negative regulation of mitochondrial depolarization PubMed 
    involved_in negative regulation of neutrophil activation PubMed 
    involved_in negative regulation of protein-containing complex assembly PubMed 
    acts_upstream_of negative regulation of telomere maintenance PubMed 
    involved_in negative regulation of transcription by RNA polymerase II PubMed 
    involved_in neurotrophin TRK receptor signaling pathway  
    involved_in odontogenesis  
    involved_in oogenesis  
    involved_in osteoclast development  
    acts_upstream_of_or_within peptidyl-tyrosine phosphorylation PubMed 
    involved_in peptidyl-tyrosine phosphorylation PubMed 
    involved_in platelet activation  
    involved_in platelet-derived growth factor receptor signaling pathway  
    involved_in positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of Notch signaling pathway PubMed 
    involved_in positive regulation of Ras protein signal transduction  
    involved_in positive regulation of TORC1 signaling PubMed 
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of bone resorption  
    involved_in positive regulation of canonical Wnt signaling pathway  
    involved_in positive regulation of cytokine production  
    involved_in positive regulation of dephosphorylation PubMed 
    involved_in positive regulation of epithelial cell migration PubMed 
    involved_in positive regulation of glucose metabolic process  
    involved_in positive regulation of glycolytic process  
    involved_in positive regulation of insulin receptor signaling pathway  
    involved_in positive regulation of integrin activation PubMed 
    involved_in positive regulation of lamellipodium morphogenesis PubMed 
    involved_in positive regulation of male germ cell proliferation  
    involved_in positive regulation of ovarian follicle development  
    involved_in positive regulation of peptidyl-tyrosine phosphorylation PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of platelet-derived growth factor receptor-beta signaling pathway  
    involved_in positive regulation of podosome assembly  
    involved_in positive regulation of protein localization to nucleus  
    involved_in positive regulation of protein processing  
    involved_in positive regulation of protein serine/threonine kinase activity PubMed 
    involved_in positive regulation of protein transport  
    involved_in positive regulation of small GTPase mediated signal transduction PubMed 
    involved_in positive regulation of smooth muscle cell migration  
    involved_in positive regulation of vascular associated smooth muscle cell proliferation  
    involved_in primary ovarian follicle growth  
    involved_in progesterone receptor signaling pathway  
    involved_in progesterone receptor signaling pathway  
    involved_in protein autophosphorylation PubMed 
    involved_in protein destabilization  
    involved_in regulation of bone resorption PubMed 
    involved_in regulation of caveolin-mediated endocytosis PubMed 
    involved_in regulation of cell projection assembly  
    involved_in regulation of cell-cell adhesion PubMed 
    involved_in regulation of early endosome to late endosome transport PubMed 
    involved_in regulation of epithelial cell migration PubMed 
    involved_in regulation of heart rate by cardiac conduction  
    involved_in regulation of intracellular estrogen receptor signaling pathway  
    involved_in regulation of toll-like receptor 3 signaling pathway PubMed 
    involved_in regulation of vascular permeability PubMed 
    involved_in response to acidic pH  
    involved_in response to electrical stimulus  
    involved_in response to interleukin-1 PubMed 
    involved_in response to mechanical stimulus  
    involved_in response to mineralocorticoid  
    involved_in response to nutrient levels  
    involved_in response to xenobiotic stimulus  
    involved_in signal complex assembly PubMed 
    involved_in signal transduction PubMed 
    involved_in skeletal muscle cell proliferation  
    involved_in spermatogenesis  
    involved_in stimulatory C-type lectin receptor signaling pathway  
    involved_in stress fiber assembly PubMed 
    involved_in substrate adhesion-dependent cell spreading  
    involved_in symbiont entry into host cell  
    involved_in transcytosis  
    involved_in transforming growth factor beta receptor signaling pathway PubMed 
    involved_in uterus development  
    involved_in vascular endothelial growth factor receptor signaling pathway  
    Items 1 - 25 of 123
    Items 1 - 20 of 27
    Component Evidence Code Pubs
    located_in actin filament  
    located_in caveola PubMed 
    located_in cell junction  
    located_in cell-cell junction PubMed 
    located_in cytoplasm PubMed 
    located_in cytosol PubMed 
    located_in cytosol  
    located_in dendritic filopodium  
    located_in dendritic growth cone  
    located_in extracellular exosome PubMed 
    located_in focal adhesion  
    located_in glutamatergic synapse  
    located_in late endosome PubMed 
    located_in lysosome PubMed 
    located_in membrane raft  
    located_in mitochondrial inner membrane PubMed 
    located_in mitochondrion PubMed 
    located_in neuronal cell body  
    located_in nucleoplasm  
    located_in perinuclear region of cytoplasm PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in podosome  
    located_in postsynaptic specialization, intracellular component  
    located_in ruffle membrane  
    located_in synaptic membrane  
    Items 1 - 20 of 27

    General protein information

    Preferred Names
    proto-oncogene tyrosine-protein kinase Src
    Names
    proto-oncogene c-Src
    protooncogene SRC, Rous sarcoma
    tyrosine kinase pp60c-src
    tyrosine-protein kinase SRC-1
    v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
    NP_005408.1
    NP_938033.1
    XP_016883515.1
    XP_047296352.1
    XP_047296353.1
    XP_047296354.1
    XP_047296355.1
    XP_047296356.1
    XP_047296357.1
    XP_047296358.1
    XP_047296359.1
    XP_047296360.1
    XP_047296361.1
    XP_047296362.1
    XP_047296363.1
    XP_047296364.1
    XP_047296365.1
    XP_047296366.1
    XP_047296367.1
    XP_047296368.1
    XP_047296369.1
    XP_054179874.1
    XP_054179875.1
    XP_054179876.1
    XP_054179877.1
    XP_054179878.1
    XP_054179879.1
    XP_054179880.1
    XP_054179881.1
    XP_054179882.1
    XP_054179883.1
    XP_054179884.1
    XP_054179885.1
    XP_054179886.1
    XP_054179887.1
    XP_054179888.1
    XP_054179889.1
    XP_054179890.1
    XP_054179891.1
    XP_054179892.1
    XP_054189256.1
    XP_054189257.1
    XP_054189258.1
    XP_054189259.1
    XP_054189260.1
    XP_054189261.1
    XP_054189262.1
    XP_054189263.1
    XP_054189264.1
    XP_054189265.1
    XP_054189266.1
    XP_054189267.1
    XP_054189268.1
    XP_054189269.1
    XP_054189270.1
    XP_054189271.1
    XP_054189272.1
    XP_054189273.1
    XP_054189274.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023033.1 RefSeqGene

      Range
      6444..65748
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1018

    mRNA and Protein(s)

    1. NM_005417.5 → NP_005408.1  proto-oncogene tyrosine-protein kinase Src

      See identical proteins and their annotated locations for NP_005408.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AL034422, AL133293, KF456893
      Consensus CDS
      CCDS13294.1
      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
      Conserved Domains (3) summary
      cd10365
      Location:147 → 247
      SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
      cd12008
      Location:88 → 143
      SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
      cd05071
      Location:260 → 536
      PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
    2. NM_198291.3 → NP_938033.1  proto-oncogene tyrosine-protein kinase Src

      See identical proteins and their annotated locations for NP_938033.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AL133293, AW135290, BC051270, CD364525, HY016645
      Consensus CDS
      CCDS13294.1
      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
      Related
      ENSP00000362680.2, ENST00000373578.7
      Conserved Domains (3) summary
      cd10365
      Location:147 → 247
      SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
      cd12008
      Location:88 → 143
      SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
      cd05071
      Location:260 → 536
      PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      37344699..37406050
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047440399.1 → XP_047296355.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    2. XM_047440400.1 → XP_047296356.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    3. XM_047440407.1 → XP_047296363.1  proto-oncogene tyrosine-protein kinase Src isoform X3

    4. XM_047440396.1 → XP_047296352.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    5. XM_047440402.1 → XP_047296358.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    6. XM_047440411.1 → XP_047296367.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    7. XM_047440405.1 → XP_047296361.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    8. XM_047440408.1 → XP_047296364.1  proto-oncogene tyrosine-protein kinase Src isoform X3

    9. XM_047440397.1 → XP_047296353.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    10. XM_047440401.1 → XP_047296357.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    11. XM_047440410.1 → XP_047296366.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    12. XM_047440406.1 → XP_047296362.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    13. XM_047440398.1 → XP_047296354.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    14. XM_047440403.1 → XP_047296359.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    15. XM_047440413.1 → XP_047296369.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    16. XM_047440409.1 → XP_047296365.1  proto-oncogene tyrosine-protein kinase Src isoform X3

    17. XM_017028026.2 → XP_016883515.1  proto-oncogene tyrosine-protein kinase Src isoform X1

      UniProtKB/Swiss-Prot
      P12931
      Related
      ENSP00000362659.2, ENST00000373558.2
      Conserved Domains (3) summary
      cd10365
      Location:153 → 253
      SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
      cd12008
      Location:88 → 149
      SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
      cd05071
      Location:266 → 542
      PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
    18. XM_047440412.1 → XP_047296368.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
      Related
      ENSP00000362668.2, ENST00000373567.6
    19. XM_047440404.1 → XP_047296360.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791812.1 Reference GRCh38.p14 PATCHES

      Range
      254201..315552
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333285.1 → XP_054189260.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    2. XM_054333286.1 → XP_054189261.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    3. XM_054333293.1 → XP_054189268.1  proto-oncogene tyrosine-protein kinase Src isoform X3

    4. XM_054333281.1 → XP_054189256.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    5. XM_054333288.1 → XP_054189263.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    6. XM_054333297.1 → XP_054189272.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    7. XM_054333291.1 → XP_054189266.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    8. XM_054333294.1 → XP_054189269.1  proto-oncogene tyrosine-protein kinase Src isoform X3

    9. XM_054333282.1 → XP_054189257.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    10. XM_054333287.1 → XP_054189262.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    11. XM_054333296.1 → XP_054189271.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    12. XM_054333292.1 → XP_054189267.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    13. XM_054333283.1 → XP_054189258.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    14. XM_054333289.1 → XP_054189264.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    15. XM_054333299.1 → XP_054189274.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    16. XM_054333295.1 → XP_054189270.1  proto-oncogene tyrosine-protein kinase Src isoform X3

    17. XM_054333284.1 → XP_054189259.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    18. XM_054333298.1 → XP_054189273.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    19. XM_054333290.1 → XP_054189265.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      39068774..39130114
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054323903.1 → XP_054179878.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    2. XM_054323904.1 → XP_054179879.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    3. XM_054323911.1 → XP_054179886.1  proto-oncogene tyrosine-protein kinase Src isoform X3

    4. XM_054323899.1 → XP_054179874.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    5. XM_054323906.1 → XP_054179881.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    6. XM_054323915.1 → XP_054179890.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    7. XM_054323909.1 → XP_054179884.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    8. XM_054323912.1 → XP_054179887.1  proto-oncogene tyrosine-protein kinase Src isoform X3

    9. XM_054323900.1 → XP_054179875.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    10. XM_054323905.1 → XP_054179880.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    11. XM_054323914.1 → XP_054179889.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    12. XM_054323910.1 → XP_054179885.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    13. XM_054323901.1 → XP_054179876.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    14. XM_054323907.1 → XP_054179882.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    15. XM_054323917.1 → XP_054179892.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    16. XM_054323913.1 → XP_054179888.1  proto-oncogene tyrosine-protein kinase Src isoform X3

    17. XM_054323902.1 → XP_054179877.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    18. XM_054323916.1 → XP_054179891.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
    19. XM_054323908.1 → XP_054179883.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      E1P5V4, P12931, Q76P87, Q86VB9, Q9H5A8
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