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    HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 [ Homo sapiens (human) ]

    Gene ID: 3189, updated on 10-Dec-2024

    Summary

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    Official Symbol
    HNRNPH3provided by HGNC
    Official Full Name
    heterogeneous nuclear ribonucleoprotein H3provided by HGNC
    Primary source
    HGNC:HGNC:5043
    See related
    Ensembl:ENSG00000096746 MIM:602324; AllianceGenome:HGNC:5043
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    2H9; HNRPH3
    Summary
    This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is localized in nuclear bodies of the nucleus. This protein is involved in the splicing process and it also participates in early heat shock-induced splicing arrest by transiently leaving the hnRNP complexes. Several alternatively spliced transcript variants have been noted for this gene, however, not all are fully characterized. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in endometrium (RPKM 44.3), ovary (RPKM 43.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See HNRNPH3 in Genome Data Viewer
    Location:
    10q21.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (68331693..68343196)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (69200902..69212407)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (70091450..70102953)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_16219 Neighboring gene long intergenic non-protein coding RNA 2640 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_16253 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:70010536-70011036 Neighboring gene keratin 19 pseudogene 4 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_16457 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_16478 Neighboring gene MPRA-validated peak989 silencer Neighboring gene MPRA-validated peak990 silencer Neighboring gene phenazine biosynthesis like protein domain containing Neighboring gene MPRA-validated peak991 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3460 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_16557 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3461 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3462 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:70091533-70092347 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:70092348-70093161 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_16564 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_16571 Neighboring gene MPRA-validated peak992 silencer Neighboring gene RUN and FYVE domain containing 2 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_16583 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_16593 Neighboring gene MPRA-validated peak994 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:70166191-70166692 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:70166693-70167192 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_16635 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_16643 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_16656 Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_16661/16662 and experimental_16666/16667 Neighboring gene ribosomal protein L26 pseudogene 29 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_16674 Neighboring gene DNA replication helicase/nuclease 2 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_16683 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_16686/16687 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_16694 Neighboring gene RNA, 5S ribosomal pseudogene 319

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Cloning of human 2H9 heterogeneous nuclear ribonucleoproteins. Relation with splicing and early heat shock-induced splicing arrest. Mahé D, et al. J Biol Chem, 1997 Jan 17. PMID 8999868
    2. Identification of Hnrph3 as an autoantigen for acute anterior uveitis. Kim Y, et al. Clin Immunol, 2011 Jan. PMID 20943442, Free PMC Article
    3. The hnRNP 2H9 gene, which is involved in the splicing reaction, is a multiply spliced gene. Honoré B. Biochim Biophys Acta, 2000 Jun 21. PMID 10858537
    4. A post-translational modification of nuclear proteins, N(G),N(G)-dimethyl-Arg, found in a natural HLA class I peptide ligand. Yagüe J, et al. Protein Sci, 2000 Nov. PMID 11152131, Free PMC Article
    5. The repertoire of genetic alterations in salivary duct carcinoma including a novel HNRNPH3-ALK rearrangement. Dogan S, et al. Hum Pathol, 2019 Jun. PMID 30946933, Free PMC Article

    See all (190) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Long Noncoding RNA RP11-115N4.1 Promotes Inflammatory Responses by Interacting With HNRNPH3 and Enhancing the Transcription of HSP70 in Unexplained Recurrent Spontaneous Abortion.
      Title: Long Noncoding RNA RP11-115N4.1 Promotes Inflammatory Responses by Interacting With HNRNPH3 and Enhancing the Transcription of HSP70 in Unexplained Recurrent Spontaneous Abortion.
    2. A novel heterogeneous nuclear ribonucleoprotein H3-ALK receptor tyrosine kinase rearrangement was found in one de novo salivary duct carcinoma
      Title: The repertoire of genetic alterations in salivary duct carcinoma including a novel HNRNPH3-ALK rearrangement.
    3. Using ORF phage display, heterogeneous nuclear ribonucleoprotein H3 (Hnrph3) was, among other candidates, identified as an autoantigen for acute anterior uveitis.
      Title: Identification of Hnrph3 as an autoantigen for acute anterior uveitis.
    4. Observational study of gene-disease association. (HuGE Navigator)
      Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Rev rev HIV-1 Rev interacting protein, heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with HNRNPH3 is increased by RRE PubMed
    Tat tat Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS PubMed
    tat HIV-1 Tat is identified to have a physical interaction with heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ34092

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA processing TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in RNA splicing TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in epithelial cell differentiation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of spliceosomal complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of spliceosomal complex TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    heterogeneous nuclear ribonucleoprotein H3
    Names
    heterogeneous nuclear ribonucleoprotein 2H9
    hnRNP 2H9
    hnRNP H3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001322434.2 → NP_001309363.1  heterogeneous nuclear ribonucleoprotein H3 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), along with variants 2H9, 4, and 5, encodes isoform a.
      Source sequence(s)
      AC016395
      Consensus CDS
      CCDS7278.1
      UniProtKB/Swiss-Prot
      A8K682, B3KRE1, P31942, Q9BSX1, Q9NP53, Q9NP96, Q9NPA7, Q9NPI4, Q9UFU4, Q9Y4J5
      UniProtKB/TrEMBL
      Q53F48
      Conserved Domains (2) summary
      cd12735
      Location:195 → 269
      RRM3_hnRNPH3; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
      cd12732
      Location:1 → 93
      RRM2_hnRNPH3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins

    2. NM_001322436.2 → NP_001309365.1  heterogeneous nuclear ribonucleoprotein H3 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), along with variants 2H9, 3, and 5, encodes isoform a.
      Source sequence(s)
      AC016395
      Consensus CDS
      CCDS7278.1
      UniProtKB/Swiss-Prot
      A8K682, B3KRE1, P31942, Q9BSX1, Q9NP53, Q9NP96, Q9NPA7, Q9NPI4, Q9UFU4, Q9Y4J5
      UniProtKB/TrEMBL
      Q53F48
      Related
      ENST00000491200.5
      Conserved Domains (2) summary
      cd12735
      Location:195 → 269
      RRM3_hnRNPH3; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
      cd12732
      Location:1 → 93
      RRM2_hnRNPH3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins

    3. NM_001322437.2 → NP_001309366.1  heterogeneous nuclear ribonucleoprotein H3 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), along with variants 2H9, 3, and 4, encodes isoform a.
      Source sequence(s)
      AC016395
      Consensus CDS
      CCDS7278.1
      UniProtKB/Swiss-Prot
      A8K682, B3KRE1, P31942, Q9BSX1, Q9NP53, Q9NP96, Q9NPA7, Q9NPI4, Q9UFU4, Q9Y4J5
      UniProtKB/TrEMBL
      Q53F48
      Conserved Domains (2) summary
      cd12735
      Location:195 → 269
      RRM3_hnRNPH3; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
      cd12732
      Location:1 → 93
      RRM2_hnRNPH3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins

    4. NM_001322438.1 → NP_001309367.1  heterogeneous nuclear ribonucleoprotein H3 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), along with variants 2H9A, 7, 8, and 9, encodes isoform b.
      Source sequence(s)
      AC016395
      Consensus CDS
      CCDS7279.1
      UniProtKB/TrEMBL
      Q53F48
      Conserved Domains (2) summary
      cd12735
      Location:180 → 254
      RRM3_hnRNPH3; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
      cd12732
      Location:1 → 93
      RRM2_hnRNPH3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins

    5. NM_001322439.2 → NP_001309368.1  heterogeneous nuclear ribonucleoprotein H3 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), along with variants 2H9A, 6, 8, and 9, encodes isoform b.
      Source sequence(s)
      AC016395
      Consensus CDS
      CCDS7279.1
      UniProtKB/TrEMBL
      Q53F48
      Conserved Domains (2) summary
      cd12735
      Location:180 → 254
      RRM3_hnRNPH3; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
      cd12732
      Location:1 → 93
      RRM2_hnRNPH3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins

    6. NM_001322440.2 → NP_001309369.1  heterogeneous nuclear ribonucleoprotein H3 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8), along with variants 2H9A, 6, 7, and 9, encodes isoform b.
      Source sequence(s)
      AC016395
      Consensus CDS
      CCDS7279.1
      UniProtKB/TrEMBL
      Q53F48
      Conserved Domains (2) summary
      cd12735
      Location:180 → 254
      RRM3_hnRNPH3; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
      cd12732
      Location:1 → 93
      RRM2_hnRNPH3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins

    7. NM_001322441.2 → NP_001309370.1  heterogeneous nuclear ribonucleoprotein H3 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), along with variants 2H9A, 6, 7, and 8, encodes isoform b.
      Source sequence(s)
      AC016395
      Consensus CDS
      CCDS7279.1
      UniProtKB/TrEMBL
      Q53F48
      Conserved Domains (2) summary
      cd12735
      Location:180 → 254
      RRM3_hnRNPH3; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
      cd12732
      Location:1 → 93
      RRM2_hnRNPH3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins

    8. NM_001322442.2 → NP_001309371.1  heterogeneous nuclear ribonucleoprotein H3 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) and variant 11 both encode the same isoform (c).
      Source sequence(s)
      AC016395
      UniProtKB/TrEMBL
      Q53F48
      Conserved Domains (2) summary
      cd12735
      Location:189 → 263
      RRM3_hnRNPH3; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
      cd12732
      Location:1 → 93
      RRM2_hnRNPH3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins

    9. NM_001322443.2 → NP_001309372.1  heterogeneous nuclear ribonucleoprotein H3 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) and variant 10 both encode the same isoform (c).
      Source sequence(s)
      AC016395
      UniProtKB/TrEMBL
      Q53F48
      Conserved Domains (2) summary
      cd12735
      Location:189 → 263
      RRM3_hnRNPH3; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
      cd12732
      Location:1 → 93
      RRM2_hnRNPH3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins

    10. NM_001322444.2 → NP_001309373.1  heterogeneous nuclear ribonucleoprotein H3 isoform d

      Status: REVIEWED

      Source sequence(s)
      AC016395
      UniProtKB/TrEMBL
      B4DHY1
      Conserved Domains (1) summary
      cl17169
      Location:87 → 161
      RRM_SF; RNA recognition motif (RRM) superfamily

    11. NM_001322445.1 → NP_001309374.1  heterogeneous nuclear ribonucleoprotein H3 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), along with variants 14, 15, 16, and 17, encodes isoform e.
      Source sequence(s)
      AC016395
      Conserved Domains (1) summary
      cl17169
      Location:64 → 138
      RRM_SF; RNA recognition motif (RRM) superfamily

    12. NM_001322446.2 → NP_001309375.1  heterogeneous nuclear ribonucleoprotein H3 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), along with variants 13, 15, 16, and 17, encodes isoform e.
      Source sequence(s)
      AC016395
      Conserved Domains (1) summary
      cl17169
      Location:64 → 138
      RRM_SF; RNA recognition motif (RRM) superfamily

    13. NM_001322447.2 → NP_001309376.1  heterogeneous nuclear ribonucleoprotein H3 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15), along with variants 13, 14, 16, and 17, encodes isoform e.
      Source sequence(s)
      AC016395
      Conserved Domains (1) summary
      cl17169
      Location:64 → 138
      RRM_SF; RNA recognition motif (RRM) superfamily

    14. NM_001322448.2 → NP_001309377.1  heterogeneous nuclear ribonucleoprotein H3 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), along with variants 13, 14, 15, and 17, encodes isoform e.
      Source sequence(s)
      AC016395
      Conserved Domains (1) summary
      cl17169
      Location:64 → 138
      RRM_SF; RNA recognition motif (RRM) superfamily

    15. NM_001322449.2 → NP_001309378.1  heterogeneous nuclear ribonucleoprotein H3 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17), along with variants 13, 14, 15, and 16, encodes isoform e.
      Source sequence(s)
      AC016395
      Conserved Domains (1) summary
      cl17169
      Location:64 → 138
      RRM_SF; RNA recognition motif (RRM) superfamily

    16. NM_001322450.2 → NP_001309379.1  heterogeneous nuclear ribonucleoprotein H3 isoform f

      Status: REVIEWED

      Source sequence(s)
      AC016395
      Conserved Domains (1) summary
      cl17169
      Location:58 → 132
      RRM_SF; RNA recognition motif (RRM) superfamily

    17. NM_001322451.2 → NP_001309380.1  heterogeneous nuclear ribonucleoprotein H3 isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19), along with variants 20 and 21, encodes isoform g.
      Source sequence(s)
      AC016395
      Conserved Domains (1) summary
      cl17169
      Location:26 → 100
      RRM_SF; RNA recognition motif (RRM) superfamily

    18. NM_001322452.2 → NP_001309381.1  heterogeneous nuclear ribonucleoprotein H3 isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (20), along with variants 19 and 21, encodes isoform g.
      Source sequence(s)
      AC016395
      Conserved Domains (1) summary
      cl17169
      Location:26 → 100
      RRM_SF; RNA recognition motif (RRM) superfamily

    19. NM_001322453.2 → NP_001309382.1  heterogeneous nuclear ribonucleoprotein H3 isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (21), along with variants 19 and 20, encodes isoform g.
      Source sequence(s)
      AC016395
      Conserved Domains (1) summary
      cl17169
      Location:26 → 100
      RRM_SF; RNA recognition motif (RRM) superfamily

    20. NM_012207.3 → NP_036339.1  heterogeneous nuclear ribonucleoprotein H3 isoform a

      See identical proteins and their annotated locations for NP_036339.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2H9) encodes the longest isoform (a). Variants 2H9, 3, 4, and 5 all encode the same isoform (a).
      Source sequence(s)
      AF132362, AK223441, AW189387, DA486117
      Consensus CDS
      CCDS7278.1
      UniProtKB/Swiss-Prot
      A8K682, B3KRE1, P31942, Q9BSX1, Q9NP53, Q9NP96, Q9NPA7, Q9NPI4, Q9UFU4, Q9Y4J5
      UniProtKB/TrEMBL
      Q53F48
      Related
      ENSP00000265866.7, ENST00000265866.12
      Conserved Domains (2) summary
      cd12735
      Location:195 → 269
      RRM3_hnRNPH3; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
      cd12732
      Location:1 → 93
      RRM2_hnRNPH3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins

    21. NM_021644.4 → NP_067676.2  heterogeneous nuclear ribonucleoprotein H3 isoform b

      See identical proteins and their annotated locations for NP_067676.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2H9A) uses an alternative donor splice site at one of the internal coding exons compared to transcript variant 2H9. However, it maintains the reading frame and encodes an isoform (b) that is missing a 15 aa segment compared to isoform a. Variants 2H9A, 6, 7, 8, and 9 all encode the same isoform (b).
      Source sequence(s)
      AW189387, BC039824, DA486117
      Consensus CDS
      CCDS7279.1
      UniProtKB/TrEMBL
      Q53F48
      Related
      ENSP00000346726.5, ENST00000354695.5
      Conserved Domains (2) summary
      cd12735
      Location:180 → 254
      RRM3_hnRNPH3; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
      cd12732
      Location:1 → 93
      RRM2_hnRNPH3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      68331693..68343196
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      69200902..69212407
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P31942.2 GenPept UniProtKB/Swiss-Prot:P31942

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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