MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MAPK8IP2provided by HGNC
Official Full Name: mitogen-activated protein kinase 8 interacting protein 2provided by HGNC
Primary source: HGNC:HGNC:6883
See related: Ensembl:ENSG00000008735 MIM:607755; AllianceGenome:HGNC:6883
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IB2; IB-2; JIP2; PRKM8IPL
Summary: This gene encodes a scaffold protein that is thought to be involved in the regulation of the c-Jun amino-terminal kinase signaling pathway. This protein has been shown to interact with and regulate the activity of MAPK8/JNK1 and MAP2K7/MKK7 kinases. [provided by RefSeq, Jun 2017]
Expression: Biased expression in brain (RPKM 21.8), adrenal (RPKM 2.8) and 2 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 22q13.33

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	22	NC_000022.11 (50600793..50613978)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	22	NC_060946.1 (51111308..51124536)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	22	NC_000022.10 (51039222..51052406)

Chromosome 22 - NC_000022.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structural basis of homodimerization of the JNK scaffold protein JIP2 and its heterodimerization with JIP1.
Title: Structural basis of homodimerization of the JNK scaffold protein JIP2 and its heterodimerization with JIP1.
Human IB2 mutation has a role as a contributing genetic factor in chromosome 22-associated cognitive disorders.
Title: Behavioral and cerebellar transmission deficits in mice lacking the autism-linked gene islet brain-2.
there is a signaling module in which IB2 scaffolds a MLK3/MKK/p38delta kinase cascade.
Title: Fibroblast growth factor homologous factors and the islet brain-2 scaffold protein regulate activation of a stress-activated protein kinase.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G65735 (e-PCR)
- UniSTS:166996

SHGC-2955 (e-PCR)
- UniSTS:12001

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables JUN kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables MAP-kinase scaffold activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP-kinase scaffold activity	IDA Inferred from Direct Assay more info	PubMed
enables MAP-kinase scaffold activity	NAS Non-traceable Author Statement more info	PubMed
enables amyloid-beta binding	NAS Non-traceable Author Statement more info	PubMed
enables kinesin binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activator activity	IGI Inferred from Genetic Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables structural molecule activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in JNK cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in behavioral fear response	ISS Inferred from Sequence or Structural Similarity more info
involved_in dendrite morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in excitatory postsynaptic potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in mating behavior	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in nonassociative learning	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of stress-activated MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in regulation of AMPA receptor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of JNK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of NMDA receptor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of signaling receptor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of synaptic transmission, glutamatergic	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal complex assembly	TAS Traceable Author Statement more info	PubMed
involved_in social behavior	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: C-Jun-amino-terminal kinase-interacting protein 2

Names: JNK MAP kinase scaffold protein 2; JNK MAP kinase scaffold protein JIP2; JNK-interacting protein 2; homologous to mouse JIP-1; islet-brain 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_032955.2 RefSeqGene

Range

5109..18294

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_012324.6 → NP_036456.1 C-Jun-amino-terminal kinase-interacting protein 2

See identical proteins and their annotated locations for NP_036456.1

Status: REVIEWED

Source sequence(s)

AF136382, AI066766, AK094442, U62317

Consensus CDS

CCDS74886.1

UniProtKB/Swiss-Prot

Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4

UniProtKB/TrEMBL

Q86VW5

Related

ENSP00000330572.4, ENST00000329492.6

Conserved Domains (2) summary

cd11942
Location:608 → 662

SH3_JIP2; Src homology 3 domain of JNK-interacting protein 2

cd01212
Location:679 → 824

PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000022.11 Reference GRCh38.p14 Primary Assembly

Range

50600793..50613978

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011530679.3 → XP_011528981.1 C-Jun-amino-terminal kinase-interacting protein 2 isoform X1

UniProtKB/TrEMBL

Q86VW5

Conserved Domains (2) summary

cd11942
Location:609 → 663

SH3_JIP2; Src homology 3 domain of JNK-interacting protein 2

cd01212
Location:680 → 825

PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain
XM_011530680.3 → XP_011528982.1 C-Jun-amino-terminal kinase-interacting protein 2 isoform X2

UniProtKB/TrEMBL

Q86VW5

Conserved Domains (2) summary

cd11942
Location:571 → 625

SH3_JIP2; Src homology 3 domain of JNK-interacting protein 2

cd01212
Location:642 → 787

PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain
XM_011530681.3 → XP_011528983.1 C-Jun-amino-terminal kinase-interacting protein 2 isoform X3

UniProtKB/TrEMBL

Q86VW5

Conserved Domains (2) summary

cd11942
Location:564 → 618

SH3_JIP2; Src homology 3 domain of JNK-interacting protein 2

cd01212
Location:635 → 780

PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain

Alternate T2T-CHM13v2.0

Genomic

NC_060946.1 Alternate T2T-CHM13v2.0

Range

51111308..51124536

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054325363.1 → XP_054181338.1 C-Jun-amino-terminal kinase-interacting protein 2 isoform X1

UniProtKB/TrEMBL

Q86VW5
XM_054325364.1 → XP_054181339.1 C-Jun-amino-terminal kinase-interacting protein 2 isoform X2

UniProtKB/TrEMBL

Q86VW5
XM_054325365.1 → XP_054181340.1 C-Jun-amino-terminal kinase-interacting protein 2 isoform X3

UniProtKB/TrEMBL

Q86VW5

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_016431.3: Suppressed sequence

Description

NM_016431.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
NM_139124.1: Suppressed sequence

Description

NM_139124.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.